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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Evidence for a 15; 17translocation in every patient with acute promyelmytic leukemia显示文摘 | LARSON R A KONDO K VARDIMAN J W BUTLER A E GOLOMB H M ROWLEY J D | 1984 | Am J Med1984，76，5： | 1 |
| 3 | Diurnal variation of radon and mixing heights along a coast: a case study 显示文摘 | Hsu S A Larson R E Bressan D J | 1980 | Journal of Geophysical Research1980，85，： | 1 |
| 4 | Sitagliptin,a dipeptidyl peptidase-4 inhibitor,does not affect the pharmaeokinetics of ethinyl estradiol or norethindrone in healthy female subjects显示文摘 | Migoya E Larson P Bergman A et a1 | 2011 | J Clin Pharmacol2011，51，9： | 1 |
| 5 | Molecular phylogenetics of Squamata: the position of snakes, amphisbaenians, and dibamids, and the root of the squamate tree显示文摘 | Townsend T M Larson A Louis E | 2004 | Systematic Biology2004，53，5： | 1 |
| 6 | Efficacy and safety of gemtuzumab ozogamicin in patients with CD33positive acute myeloid leukemia in first relapse显示文摘 | Sievers E L Larson R A Stadtmauer E A | 2001 | J Clin Oncol2001，，： | 1 |
| 7 | Rebound of five one-dimensionally compressed unsaturated granular soils显示文摘 | STONE J A LARSON W E | 1980 | Soil Science Society of America Journal1980，44，4： | 1 |
| 8 | Predicting the effects of tillage and crop residue management on soil erosion显示文摘 | GUPTA S C ONSTAD C A LARSON W E | 1979 | Soil Water Conserv1979，34，： | 1 |
| 9 | Calcium carbonate saturation index and alkalinity interpretations 显示文摘 | LARSON T E BUSWELL A M | 1942 | Journal of American Water Works Association1942，34，11： | 1 |
| 10 | The economics of air pollution health risks in Russia: a case study of Volgograd 显示文摘 | Larson B A Avaliani S Golub A Rosen S Shaposhnikov D Strukova E Vincent J R Wolff S K | 1999 | World development1999，27，10： | 1 |
| 11 | The satisfaction with life scale' 显示文摘 | DIENER E EMMONMS R A LARSON R J GRIF- FIN S | 1985 | Journal of Personality Assessment1985，49，： | 1 |
| 12 | Final report of the efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first recurrence显示文摘 | Larson R A Sievers E L Stadtmauer E A | 2005 | Cancer2005，104，7： | 1 |
| 13 | Applying power systems stabilizers,part 1:General concepts;part 2:Performance objectives and tuning concepts;part 3:Practical consideration显示文摘 | LARSON E V SWANN S A | 1981 | IEEE Transactions on Power Apparatus and Systems1981，100，9： | 1 |
| 14 | Is gratitude a moral affect 显示文摘 | McCullough M E Kilpatrick S D Emmons R A larson D B | 2001 | Psychological Bulletin2001，127，24： | 1 |
| 15 | NCSOIL, a model of nitrogen and carbon transformation in soil: Description, calibration, and behavior显示文摘 | Moiina j A E Clapp C E Shaffer M J Chichester F W Larson W E | 1983 | Soil Science Society of America Journal1983，47，1： | 1 |
| 16 | Monoterpenes in the glandular trichomes of tomato are synthesized from a neryl diphosphate precursor rather than geranyl diphosphate显示文摘 | Schilmiller A.L Schauvinhold I Larson M Xu R Charbonneau A.L Schmidt A Wilkerson C Last R.L and Pichersky E | | 0，，： | 1 |
| 17 | Retroperitoneal robot-assisted partial nephrectomy for posterior renal masses is associated with earlier hospital discharge: a single-institution retrospective comparison显示文摘 | Kim E H Larson J A Potretzke A M Hulsey N K Bhayani S B Figenshau R S | 2015 | J Endourol2015，29，： | 1 |
| 18 | Feeding value of wet distillers byproducts for finishing ruminants显示文摘 | Larson E M Stock R A Klopfenstein T J | 1993 | Journal of Animal Science1993，71，： | 1 |
| 19 | A dynamic estimator for tracking the state of a power system显示文摘 | Debs A S Larson R E | 1970 | IEEE Transactions on Power Apparatus and Systems1970，89，7： | 1 |
| 20 | Molecular phylogeneties of Squamata : the position of snakes, am- phisbaenians ,and dibamids ,and the root of the squamate tree显示文摘 | TOWNSEND T M LARSON A LOUIS E | 2004 | Systematic Biology2004，53，5： | 1 |
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