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| 1 | Pam3CSK4 enhances adaptive immune responses to recombinant Mycobacterium bovis bacille Calmette-Guérin expressing Plasmodium falciparum C-terminus merozoite surface protein-1显示文摘Objective: To determine the effects of toll-like receptor 2(TLR-2) agonist, Pam3 CSK4, on cellular and humoral immune response against recombinant Mycobacterium bovis bacille Calmette-Guérin(rBCG) expressing the C-terminus of merozoite surface protein-1 of Plasmodium falciparum.Methods: Six groups of mice(n=6 per group) received intraperitoneal phosphate buffered saline T80(PBS-T80), BCG or rBCG in the presence or absence of Pam3 CSK4. Enzymelinked immunosorbent assay was carried out to measure serum total IgG, IgG1, IgG2 a, and Ig G2 b production. Spleens were also harvested and splenocytes were co-cultured with rBCG antigen for in vitro determination of IL-4 and IFN-γ via enzyme-linked immunosorbent assay.Results: The production of total IgG and the isotype IgG1, IgG2 a and IgG2 b was significantly higher in rBCG-immunised mice than in the BCG and PBS-T80-immunised mice, and Pam3 CSK4 further enhanced their productions. A similar pattern was also observed in IFN-γ production. Moreover, there was no significant difference in IL-4 production in all groups either in the presence or absence of Pam3 CSK4.Conclusions: We present evidence of the adjuvant effects of TLR-2 agonist in enhancing the production of total IgG, IgG1, IgG2 a, IgG2 b, as well as IFN-γ in response to rBCG. However, the presence or absence of Pam3 CSK4 had no effect on IL-4 production. | Mohamed H Abdikarim Muhammad A Abbas Munirah N Zakaria Robaiza Zakaria Rapeah Suppian | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，7： | 3 |
| 2 | Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial显示文摘 | A David Mendelow Barbara A Gregson Helen M Fernandes Gordon D Murray Graham M Teasdale D Terence Hope Abbas Karimi M Donald M Shaw David H Barer | 2005 | 2005 (9457)2005，，9457： | 2 |
| 3 | Synthesis and Antimicrobial Activity of New 1- Indole Derivatives, Their 1,2,4-Triazole Thioglycosides and Acyclic Analogs显示文摘 | El-Sayed W A R E Abdel Megeid Abbas H S | 2011 | Arch Pharm Res2011，34，： | 1 |
| 4 | Revisiting the role of IL-2 in autoimmunity 显示文摘 | DOOMS H ABBAS A K | 2010 | Eur J Immunol2010，40，6： | 1 |
| 5 | On the improvement of neural cryptography using erroneous transmitted information with error prediction显示文摘 | ALLAM A M ABBAS H M | 2010 | IEEE Trans on Neural Networks2010，21，12： | 1 |
| 6 | Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial显示文摘 | A David Mendelow Barbara A Gregson Helen M Fernandes Gordon D Murray Graham M Teasdale D Terence Hope Abbas Karimi M Donald M Shaw David H Barer | 2005 | The Lancet2005，，9457： | 1 |
| 7 | Role of NMDA re-ceptor subtypes in different forms of NMDA-dependent synap-tic plasticity显示文摘 | Li R Huang F S Abbas A K Wigstrm H | 2007 | BMC Neurosci2007，8，： | 1 |
| 8 | Evolution of oxide scale on a Ni- Mo-Cr alloy at 900 ~C 显示文摘 | U1-Hamid A Mohammed A I A1-Jaroudi S S Tawancy H M Abbas N M | 2007 | Materials Characterization2007，58，1： | 1 |
| 9 | Prognostic value of cardiac troponin T in unstable angina pectoris 显示文摘 | Alan H B Wu S A Abbas S G | 1995 | Amer J Cardiol1995，76，97： | 1 |
| 10 | Pregnancy and the cardiovascular system显示文摘 | ABBAS A E LESTER S J CONNLLY H | 2005 | Int J Cardiol2005，98，2： | 1 |
| 11 | Dynamic Stability of off-shore Structures显示文摘 | Thomas J Abbas B A H | 1980 | Journal of Mechanical Engineering Science1980，22，1： | 1 |
| 12 | A framework for preservation of cloud users’ data privacy using dynamic reconstruction of metadata显示文摘 | WAQAR A RAZA A ABBAS H | 2013 | Journal of Network and Computer Applications2013，36，1： | 1 |
| 13 | A state-of-the-art review of gas solid turbulent fluidization显示文摘 | Bi H T Ellis N Abba I A | 2000 | Chemical Engineering Science2000，55，21： | 1 |
| 14 | Insulin resistance, lipo- toxicity and endothelial dysfunction显示文摘 | Imrie H Abbas A Keamey M | 2010 | Biochim Biophys Acta2010，1801，： | 1 |
| 15 | Experimental and theoretical study of the gas-water two phase flow through a conductance multiphase Venturi meter in vertical annular(wet gas) flow显示文摘 | Abbas H Hasan A M Lucas G P | | 0，，06： | 1 |
| 16 | Prollne induces the expression of saltstress-responsive proteins and may improve the adap- tation of Pancratium rnaritimum L to salt-stress 显示文摘 | Khedr A H Abbas M A Wahid AA | 2003 | J Exp Bot2003，54，： | 1 |
| 17 | Fungal degradation of wood: initial proteomic analysis of extracellular proteins of Phanerochaete chrysosporium grown on oak substrate显示文摘 | Abbas A Koc H Liu F | 2005 | Curr Genet2005，47，1： | 1 |
| 18 | On the improvement of neural cryptography using erroneous transmitted information with error prediction显示文摘 | ALLAM A M ABBAS H M | 2010 | IEEE Transactions on Neural Networks2010，21，12： | 1 |
| 19 | Hydroxyl as a defect of the manganese dioxide lattice and its applications to the dry cell battery显示文摘 | Abbas H Nasser S A | 1996 | Journal of Power Sources1996，58，： | 1 |
| 20 | Dynamic analysis of thick rotating blades with flexible roots显示文摘 | Abbas B A H | 1985 | The Aeronautical J1985，89，： | 1 |
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