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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Recent advances in metastable alloys for hydrogen storage:a review显示文摘Development of new materials with high hydrogen storage capacity and reversible hydrogen sorp-tion performances under mild conditions has very high value in both fundamental and application aspects.In the past years,some new systems with metastable structures,such as ultra-fine nanocrystalline alloys,amorphous alloys,nanoglass alloys,immiscible alloys,high-entropy alloys,have been abundantly studied as hydrogen storage mate-rials.Many new hydrogen storage properties either from the kinetics or thermodynamics aspects have been reported.In this review,recent advances of studies on metastable alloys for hydrogen storage applications have been comprehensively reviewed.The materials preparation methods to synthesize metastable hydrogen storage alloys are firstly reviewed.Afterwards,hydrogen storage prop-erties of the metastable alloys are summarized and dis-cussed,focusing on the unique kinetics and thermodynamics properties by forming of such unique metastable structures.For examples,superior hydrogena-tion kinetics and higher hydrogen storage capacity have been achieved in Mg-based amorphous and nanoglass alloys.Destabilized thermodynamics properties can be obtained in the immiscible Mg-Mn and Mg-Zr alloys.In addition to highlighting the recent achievements of metastable alloys in the field of hydrogen storage,the remaining challenges and trends of the emerging research are also discussed. | Huai-Jun Lin Yan-Shan Lu Liu-Ting Zhang Hai-Zhen Liu Kaveh Edalati Adám Révész | 2022 | Rare Metals2022，41，6： | 4 |
| 3 | WNT and beta-catenin signalling:diseases and therapies显示文摘 | Moon RT Kohn AD De FerrariG V | 2004 | Nat Rev Genet2004，5，9： | 1 |
| 4 | Gap-junction channelsdysfunction in deafness and hearing loss显示文摘 | Martínez AD Acua R Figueroa V | 2009 | Antioxid Redox Sig-nal2009，11，2： | 1 |
| 5 | Retinal thickness in patients with mild cognitive impairment and Alzheimers' s disease 显示文摘 | Kesler A Vakhapova V Korczyn AD | 2011 | Clin Neurot Neurosurg2011，113，7： | 1 |
| 6 | Techniques and materials for skin closure in caesarean section 显示文摘 | Mackeen AD Berghella V Larsen ML | 2012 | Cochrane Database Syst Rev2012，11，00： | 1 |
| 7 | Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA 显示文摘 | JUDGE AD SOOD V SHAW JR | 2005 | Nat Biotechnol2005，23，4： | 1 |
| 8 | Comparison of aliskiren/hydrochlorothiazide combination therapy and amlodipine monotherapy in patients with stage 2 systolic hypertension and type 2 diabetes mellitus 显示文摘 | Townsend RR Forker AD Bhosekar V | 2011 | J Clin Hypertens2011，13，12： | 1 |
| 9 | Prediction of majorpulmonary complications after esophagectomy 显示文摘 | Ferguson MK Celauro AD Prachand V | 2011 | Ann Thorac Surg2011，91，5： | 1 |
| 10 | Anterior cruciate ligament reconstruction with a quadrupled hamstring autograft does not restore tibial rotation 显示文摘 | GEORGOULIS AD RISTANIS S CHOULIARAS V | 2005 | Techniques in Orthopaedics2005，20，3： | 1 |
| 11 | 2009 updated method guidelines for systematic reviews in the Cochrane Back Review Group显示文摘 | Furlan AD Pennick V Bombardier C | 2009 | Spine2009，34，18： | 1 |
| 12 | Alcohol dosing and total mortality in men and women显示文摘 | CASTELNUOVO AD CASTAMZO S BAGNARDI V | 2006 | Arch Intern Med2006，166，22： | 1 |
| 13 | Tibial rotation is not restored after ACL reconstruction with a hamstring graft 显示文摘 | GEORGOULIS AD RISTANIS S CHOULIARAS V | 2007 | Clin Orthop Relat Res2007，45，4： | 1 |
| 14 | Long-term followup of children with neonatal lupus and their unaffected siblings显示文摘 | Martin V Lee LA Askanase AD | 2002 | Arthritis Rheum2002，46，9： | 1 |
| 15 | The Emergency Coma Scale as an alternative to the Glasgow Coma Scale显示文摘 | Law AD Bhalla A Suri V | 2011 | Am J Emerg Med2011，29，7： | 1 |
| 16 | Significantly higher procalcitonin levels could differentiate Gram-negative sepsis from Gram-positive and fungal sepsis显示文摘 | Brodská H Malícková K Adámková V | 2013 | Clin Experimental Med2013，13，3： | 1 |
| 17 | The prevention of the dementia epidemic 显示文摘 | Korczyn AD Vakhapova V | 2007 | J Neurol Sci2007，257，12： | 1 |
| 18 | Diabetic state induces lipid loading and altered expression and secretion of lipoprotein lipase in human monoeyte-derived macrophages显示文摘 | Dobrian AD Lazar V Sinescu C | 2000 | Atherosclerosis2000，153，1： | 1 |
| 19 | Referral,enrollment,and delivery of cardiac rehabilitation/secondary prevention programs at clinical centers and beyond:A presidential advisory from the American Heart Association显示文摘 | Balady G J Ades P A Bittner V A | | 0，，25： | 1 |
| 20 | High telomerase activity and high HTRT mRNA expression differentiate pure myxoid and myxoid/round-cell liposarcomas显示文摘 | Schneider-Stock R Jaeger V Rys J et ad | 2000 | Int J Cancer2000，89，1： | 1 |
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