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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 3 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 4 | Molecular dynamics simulations of consolidation processes during fabrication of nanophase palladium显示文摘 | Liu C L Adams J B Siegal R W | 1994 | Nanostructured Materials1994，4，4： | 1 |
| 5 | Central pontinemyelinolysis: a hitherto undescribed disease occurring in alcoholic and malnourished patients 显示文摘 | Adams R D Victor M Mancall E L | 1959 | AMA Arch Neurol Psychiatry1959，81，4： | 1 |
| 6 | Hepatic resection for noncolorectal nonendocrine liver metastases analysis of 1 452 patients and development of a prognostic model显示文摘 | Adam R Chiche L Aloia T | 2006 | Ann Surg2006，244，4： | 1 |
| 7 | The determinants of Chinese outward foreign direct investment显示文摘 | Peter J Buckley L JeremyClegg Adam R Cross Xin Liu Hinrich Voss and Ping Zheng | | 0，，： | 1 |
| 8 | Design,Synthesis,and SAR of New Pyrrole-Oxindole Progesterone Receptor Modulators Leading to 5-(7-Fluoro-3,3-Dimethyl-2-Oxo-2,3-Dihydro-1H-Indol5-yl)-1-Methyl-1 H-Pyrrole-2-Carbonitrile (WAY-255348)显示文摘 | Fensome A Adams W R Adams A L | | 0，，： | 1 |
| 9 | Analytical models of adhesively bonded joints-Part I:literature survey显示文摘 | da Silva L F M das Neves P J C Adams R D | 2009 | International Journal of Adhesion and Adhesives2009，29，3： | 1 |
| 10 | Process configurations adapted to membrane bioreactors for enhanced biological phosphorus and nit rogen removal 显示文摘 | L ESJ FAN B GNIRSS R ADAM C | 2002 | Desalination2002，149，： | 1 |
| 11 | 显示文摘 | Adams J J Weiland T L Stanley J R | 2005 | Proc of SPIE2005，5647，： | 1 |
| 12 | Seeded region growing显示文摘 | R Adams L Bischof | 1994 | IEEE Trans actions on Pattern Analysis and Machine Intelligence1994，16，6： | 1 |
| 13 | Heregulin regulates cytoskeletal recognization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase显示文摘 | Adam L Vadamudi R Kondapaka SB | 1998 | J Bio Chem1998，273，28： | 1 |
| 14 | Vasopressin: a new target for the treatment of heart failure显示文摘 | Craig R Lee Michael L Watkins J.Herbert Patterson Wendy Gattis Christopher M O'Connor Mihai Gheorghiade Kirkwood F Adams | 2003 | American Heart Journal2003，，1： | 1 |
| 15 | Salad bars and fi'uit and vegetable consumption in elementary schools: A plate waste study 显示文摘 | ADAMS M A PELLETIER R L ZIVE M M | 2005 | Journal of the American Dietetic Association2005，105，11： | 1 |
| 16 | Impact of rpoS Deletion on Esche- richia coli Biofilms显示文摘 | Adams J L McLean R J C | 1999 | Applied and environmental microbiolo- gy1999，65，9： | 1 |
| 17 | Influence of the distillation step on the ratiosof stable isotopes of ethanol in cherry brandies显示文摘 | BAUDLER R ADAM L ROSSMANN A | 2006 | Journal of Agricultural and Food Chemistry2006，54，3： | 1 |
| 18 | Assodation between surges of follicle stimulating hormone and the emergence of follicular waves in heifers显示文摘 | Adams G P Matted R L Kastellc J Pt | 2002 | J Reprod Fertil2002，94，： | 1 |
| 19 | Seeded region growing显示文摘 | Adams R Bischof L | 1994 | IEEE Transactions on Pattern Analysis and Machine Intelligence1994，16，6： | 1 |
| 20 | Seeded region growing 显示文摘 | ADAMS R BISCHOF L | 1994 | Pattern Analysis and Machine Intelligence1994，16，6： | 1 |
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