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| 1 | Celecoxib enhances the detoxification of diethylnitrosamine in rat liver cancer显示文摘AIM:To study the effect of celecoxib(CXB) on diethylnitrosamine activation through the regulation of cytochrome P450 in a hepatocarcinogenesis model.METHODS:Six-week-old male Sprague-Dawley rats were randomly divided into fi ve groups,a non-treated group(NT) ,a diethylnitrosamine-treated group(DEN) ,a DEN+CXB-treated group(DEN+CXB) ,and CXB 8 d-treated and CXB 32 d-treated groups.The effects of celecoxib on the enzymatic activities of CYP1A1,2A,2B1/2,and 2E1 were assessed in hepatic microsomes 24 h after DEN administration.Changes in CYP1A1 and CYP2B1/2 protein expression were also evaluated.The rate of DEN metabolism was measured by the production of the deethylation metabolite acetaldehyde,and the denitrosation metabolite nitrite.RESULTS:DEN+CXB administration produced a significant increase in the enzymatic activities of CYP2B1/2 and 1A1,whereas it did not change the activities of CYP2A and 2E1,compared to that of the DEN group.CXB treatment for eight days did not produce a signif icant effect on enzymatic activity when compared to the NT group;however,when it was administered for prolonged times(CXB 32 d group) ,the enzymatic activities were increased in a similar pattern to those in the DEN+CXB group.The observed increase in the enzymatic activities in the DEN+CXB group was accompanied by an increase in the CYP2B1/2 protein levels;no changes were observed in the levels of CYP1A1.In vitro,CXB increased the denitrosation of DEN,a pathway of metabolic detoxification.The addition of SKF-525A,a preferential inhibitor of CYP2B,abrogated the denitrosation of DEN.CONCLUSION:These results suggest that the mechanism of action of CXB involves enhancement of the detoxif ication of DEN by an increasing denitrosation via CYP2B1/2. | Martha Estela Salcido-Neyoy Adolfo Sierra-Santoyo Olga Beltrán-Ramírez José Roberto Macías-Pérez Saúl Villa-Trevio | 2009 | World Journal of Gastroenterology2009，15，19： | 3 |
| 2 | Amyotrophic lateral sclerosis: a complex syndrome that needs an integrated research approach显示文摘Amyotrophic lateral sclerosis, the most common neurodegenerative disease affecting motor neurons, lacks an effective treatment. A small fraction of amyotrophic lateral sclerosis cases have a familial origin, related to mutations in causative genes, while the vast majority of amyotrophic lateral sclerosis cases are considered to be sporadic, resulting from the interaction between genes and environmental factors in predisposed individuals. During the past few years, dozens of drugs have been postulated as promising strategies for the disease after showing some beneficial effects in preclinical cellular and murine models. However, the translation into clinical practice has been largely unsuccessful and the compounds failed when were tested in clinical trials. This might be explained, at least partially, by the enormous complexity of the disease both from clinico-epidemiological and a pathogenic points of view. In this review, we will briefly comment on the complexity of the disease focusing on some recent findings, and we will suggest how amyotrophic lateral sclerosis research might be reoriented to foster the advance in the diagnostic and therapeutic questions. | Javier Riancho Francisco J.Gil-Bea Ana Santurtun Adolfo López de Munaín | 2019 | Neural Regeneration Research2019，14，2： | 2 |
| 3 | The Use of Preoperative Endoscopic Tattooing in Laparoscopic Colorectal Cancer Surgery for Endoscopically Advanced Tumors: A Prospective Comparative Clinical Study显示文摘 | Ivan Arteaga-González MD Antonio Martín-Malagón MD Eudaldo M. López-Tomassetti Fernández MD Javier Arranz-Durán MD Adolfo Parra-Blanco MD David Nicolas-Perez MD Enrique Quintero-Carrión MD Hermogenes Díaz Luis MD Angel Carrillo-Pallares MD PhD | 2006 | World Journal of Surgery2006，，4： | 2 |
| 4 | Microbiological Survey of the Human Gastric Ecosystem Using Culturing and Pyrosequencing Methods显示文摘 | Susana Delgado Raúl Cabrera-Rubio Alex Mira Adolfo Suárez Baltasar Mayo | 2013 | Microbial Ecology2013，，3： | 2 |
| 5 | Diagnostic accuracy of immunochemical versus guaiac faecal occult blood tests for colorectal cancer screening显示文摘 | Adolfo Parra-Blanco Antonio Z. Gimeno-García Enrique Quintero David Nicolás Santiago G. Moreno Alejandro Jiménez Manuel Hernández-Guerra Marta Carrillo-Palau Yoshinobu Eishi Julio López-Bastida | 2010 | Journal of Gastroenterology2010，，7： | 2 |
| 6 | Carbon dioxide reforming of methane over a metal modified Ni-Al2O3 catalyst 显示文摘 | ADOLFO E CASTRO L MARIA E | 2008 | Applied Catalysis A: General2008，343，112： | 1 |
| 7 | Optical techniques for real-time penetration monitoring for laser welding 显示文摘 | Fabfice B Adolfo C Jose M L H | 2005 | Applied Optics2005，44，19： | 1 |
| 8 | On the interharmonic conpenents generated by adjustable speed drivers显示文摘 | Francesco D R Roberto L Adolfo S | 2005 | IEEE Transactions on Power Delivery2005，20，4： | 1 |
| 9 | Fractal dimensions of mass estimated from intact and eroded soil aggregates 显示文摘 | Daniel Gimenez Janice L Karmon Adolfo Posadas Richard K Shaw | 2002 | Soil Use and Management2002，64，： | 1 |
| 10 | Exploring the effect of changes in land use on soil quality on the eastern slope of the Cofre de Perote Volcano (Mexico) 显示文摘 | ADOLFO C C KLAUDIA O L JORGE E B | 2007 | Forest Ecology and Management2007，248，： | 1 |
| 11 | Effect of superoxide dismutase from bovine eryth - rocytes on different activity parameters in adjuvant - induced arthritis 显示文摘 | Adolfo G G Jorge H A Jose L O | 1999 | Archives of Medical Research1999，30，2： | 1 |
| 12 | The best for the guest:high Andean nurse cushions of Azorella madreporica enhance arbuscular mycorrhizal status in associated plant species显示文摘 | Angelica Casanova-Katny M Adolfo Torres-Mellado G A Cavieres L A | 2011 | Mycorrhiza2011，21，7： | 1 |
| 13 | On the interharmonic conpenents generated by adjustable speed drivers显示文摘 | FRANCESCO D R ROBERTO L ADOLFO S | 2005 | IEEE Transactions on Power Delivery2005，20，4： | 1 |
| 14 | Optical techniques for real-time penetration monitoring for laser welding 显示文摘 | B Fabrice C Adolfo M L H Jose | 2005 | Applied Optics2005，，44： | 1 |
| 15 | Recent intraplate stress field in the eastern Duero Basin (N Spain)显示文摘 | Adolfo Maestro | 1998 | Terra Nova1998，10，： | 1 |
| 16 | Effect of superoxide dis- mutase from bovine erythrocytcs on different activity parameters in adjuvant - induced arthritis 显示文摘 | ADOLFO G G JORGE H A JOSE L O | 1999 | Archives of Medical Research1999，30，2： | 1 |
| 17 | On the interhar- monic conpenents generated by adjustable speed driv- ers显示文摘 | Francesco D R Roberto L Adolfo S | 2005 | IEEE Transactions on Power Delivery2005，20，4： | 1 |
| 18 | An extension of the EVM analysis for project monitoring: The Cost Control Index and the Schedule Control Index显示文摘 | Javier Pajares Adolfo López-Paredes | 2010 | International Journal of Project Management2010，，5： | 1 |
| 19 | The effects of welding processes on abrasive wear resistance for hardfacing deposits显示文摘 | John J Coronado Holman F Caicedo Adolfo L Gomez | 2009 | Tribology International2009，，42： | 1 |
| 20 | Activity of Pd/A1203 and Ru/A1203 catalysts in the hydro- genation of o-xylene effect of hiophene 显示文摘 | Adolfo Arcoya Xos6 L Seoane Luisa Ma G6mez-Sainero | 2003 | Applied Surface Science2003，211，： | 1 |
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