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| 1 | New fecal test for non-invasive Helicobacter pylori detection:A diagnostic accuracy study显示文摘AIM To assess the diagnostic accuracy of a new fecal test for detecting Helicobacter pylori(H. pylori), using ^(13)Curea breath test as the reference standard, and explore bacterial antibiotic resistance. METHODS We conducted a prospective two-center diagnostic test accuracy study. We enrolled consecutive people≥ 18 years without previous diagnosis of H. pylori infection, referred for dyspepsia between February and October 2017. At enrollment, all participants underwent 13 C-urea breath test. Participants aged over 50 years were scheduled to undergo upper endoscopy with histology. Participants collected stool samples 1-3 d after enrollment for a new fecal investigation(THD fecal test). The detection of bacterial 23 S rRNA subunit gene indicated H. pylori infection. We also used the index diagnostic test to examine mutations conferring resistance to clarithromycin and levofloxacin. Independent investigators analyzed index test and reference test standard results blinded to the other test findings. We estimated sensitivity, specificity, positive(PPV) and negative(NPV) predictive value, diagnostic accuracy, positive and negative likelihood ratio(LR), together with 95% confidence intervals(CI).RESULTS We enrolled 294 consecutive participants(age: Median 37.0 years, IQR: 29.0-46.0 years; men: 39.8%). Ninetyfive(32.3%) participants had a positive ^(13)C-urea breath test. Twenty-three(7.8%) participants underwent upper endoscopy with histology, with a full concordance between ^(13)C-urea breath test and histology in detecting H. pylori infection. Four(1.4%) out of the 294 participants withdrew from the study after the enrollment visit and did not undergo THD fecal testing. In the 290 participants who completed the study, the THD fecal test sensitivity was 90.2%(CI: 84.2%-96.3%), specificity 98.5%(CI:96.8%-100%), PPV 96.5%(CI: 92.6%-100%), NPV 95.6%(CI: 92.8%-98.4%), accuracy 95.9%(CI: 93.6%-98.2%), positive LR 59.5(CI: 19.3-183.4), negative LR 0.10(CI: 0.05-0.18). Out of 83 infected participants identified with the THD fecal test, 34(41.0%) had bacterial genotypic changes consistent with antibiotic-resistant H. pylori infection. Of these, 27(32.5%) had bacterial strains resistant to clarithromycin, 3(3.6%) to levofloxacin, and 4(4.8%) to both antibiotics. CONCLUSION The THD fecal test has high performance for the non-invasive diagnosis of H. pylori infection while additionally enabling the assessment of bacterial antibiotic resistances. | Andrea Iannone Floriana Giorgio Francesco Russo Giuseppe Riezzo Bruna Girardi Maria Pricci Suetonia C Palmer Michele Barone Mariabeatrice Principi Giovanni FM Strippoli Alfredo Di Leo Enzo Ierardi | 2018 | World Journal of Gastroenterology2018，24，27： | 5 |
| 2 | Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography–mass spectrometry显示文摘 | Michel Y Haller Stephan R Müller Christa S McArdell Alfredo C Alder Marc J.-F Suter | 2002 | Journal of Chromatography A2002，，1： | 2 |
| 3 | Rapid assessment of the cost-effectiveness of low impact development for CSO control显示文摘 | Montalto F Behr C Alfredo K | 2007 | Landscape amt Urban Planning2007，82，： | 1 |
| 4 | Satellite remote sensing analysis to monitor desertifieation processes in the crop-rangeland boundary of Argentina显示文摘 | Alfredo D C Emilio C Ana C | 2002 | Journal of Arid Environments2002，52，： | 1 |
| 5 | Dependence of NDVI and SAVI on sun/sensor geometry and its effect on FAPAR relationships in alfalfa显示文摘 | Jose C N Epiphanio Alfredo R Huete | 1995 | Remote Sens Environ1995，，51： | 1 |
| 6 | Identification and characterization of four splicing variants of ovine POU1F1 gene显示文摘 | Estela B Silvia A Alfredo C | 2006 | Gene2006，382，： | 1 |
| 7 | Odor and chemesthesis from exposures to glutaraldehyde vapor 显示文摘 | William S C Roland Sehmidt Alfredo A | 2007 | Int Arch Occup Environ Health2007，80，： | 1 |
| 8 | Effects of silicon nutrition on cadmium uptake,growth and photosynthesis of rice plants exposed to low-level cadmium显示文摘 | Chika C N Alfredo J H | 2008 | Plant and Soil2008，311，12： | 1 |
| 9 | Composition of the gaseous products of pyrolysis of tobacco under inert and oxidative conditions 显示文摘 | OSVALDA S STEFANO C ALFREDO N | 2007 | Journal of analytical and applied pyrolysis2007，79，： | 1 |
| 10 | Piezoelectric and magnetoelectric properties of lead zirconate titanate/Ni-ferrite particulate composites显示文摘 | Jungho R Alfredo V C Kenji U | 2001 | Journal of Electroceramics2001，7，： | 1 |
| 11 | Composition of the gaseous products of pyrolysis of tobacco under inert and oxidative conditions 显示文摘 | Osvalda S Stefano C Alfredo N | 2007 | Journal of Analytical and Applied Pyrolysis2007，79，12： | 1 |
| 12 | DPPH and oxygen free radicals as prooxidant of biomolecules显示文摘 | María E Alfredo M Juan C | 2008 | Toxicology in Vitro2008，22，： | 1 |
| 13 | Satellite Remote Sensing Analysis to Monit- or Desertification Processes in the Crop-rangeland Boundary of Argentina显示文摘 | Alfredo D C Emilio C Camarasaw A | 2002 | Journal of Arid Environments2002，52，： | 1 |
| 14 | Novel piezoelectric- based power supply for driving piezoelectric actuators designed for active vibration damping applications 显示文摘 | Alfredo Vazquez C Kenji U | 2001 | Journal of Electroceramics2001，7，3： | 1 |
| 15 | Satellite remote sensing analysis to monitor desertification processes in the crop-range- Iand boundary of Argentina显示文摘 | Alfredo D C Emilio C Camarasa A | 2002 | Journal of Arid Environment2002，52，1： | 1 |
| 16 | Sun/Sensor Geometry and Its Effect on fAPAR Relationships in Alfalfa显示文摘 | Jose C N Epiphanio Alfredo R Huete | 1995 | Remote Sensing of Environment1995，51，： | 1 |
| 17 | miR-21 and 221 upregulation and miR-181b downregulation in human grade Ⅱ-Ⅳ astrocytic tumors显示文摘 | Alfredo C Aquennouz M | 2009 | J Neurooncol2009，93，： | 1 |
| 18 | Some ad-vances on the Erlang(n) dual risk model显示文摘 | V R EUGENIO M R C RUI D E ALFREDO | 2014 | ASTIN Bulletin2014，45，1： | 1 |
| 19 | Piezoelectric and magnetoelectric properties of lead zinconate titanate /Ni-ferrite particulate composites 显示文摘 | Jungho Alfredo V Azqez C | 2001 | J Electroceramics2001，，7： | 1 |
| 20 | Satellite remote sensing analysis to monitor desertification processesin the croprangeland boundary of argentina显示文摘 | Alfredo D C Emilio C Camarasaw A | 2002 | Journal of Arid Environments2002，52，： | 1 |
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