|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | NEW TOXOPLASMA GONDII GENOTYPES ISOLATED FROM FREE-RANGE CHICKENS FROM THE FERNANDO DE NORONHA, BRAZIL: UNEXPECTED FINDINGS显示文摘 | Dubey J P Rajendran C Costa D G C Ferreira L R Kwok O C H Qu D Su C Marvulo M F V Alves L C Mota R A Silva J C R | 2010 | The Journal of Parasitology2010，，4： | 2 |
| 4 | Positive solu- tions for a quasilinear elliptic equations of Kirchhoff type显示文摘 | Alves C O Correa F J S A Ma T F | 2005 | Comput Math Appl2005，4，： | 1 |
| 5 | Effects of a Saccharomyces cerevisiae yeast on ruminal fermentation and fibre degradation of maize silages in cows显示文摘 | Guedes C M Gon alves D Rodrigues M A M | 2008 | Anim Feed Sci Tech2008，145，1： | 1 |
| 6 | Biomaterial-induced sar-coma:a novel model to study preneoplastic change显示文摘 | Kirkpatrick C J Alves A Khler H | 2000 | Am JPathol2000，156，4： | 1 |
| 7 | Anticardolipid antibodies titre and plasma homocysteine level independently predict intima media thickness of carotid arteries in subjects with idiopathic antiphospholipid syndrome 显示文摘 | Atnes PR Margarita A Delgado Alves C | 2002 | Lupus2002，11，4： | 1 |
| 8 | On the existence and con- centration behaviour of ground state solutions for a class of problems with critical growth 显示文摘 | Alves C O Souto M A S | 2002 | Comm Pure Appl Anal2002，3，： | 1 |
| 9 | Use of a semi-continuous culture system to studythe effect of pH on microbial metabolism of thiamin(Vitamin B1) 显示文摘 | Alves de Oliveira L Jean-Blain C Durix A | 1996 | Archiv fur Tierernahrung1996，49，19： | 1 |
| 10 | Expression of infection-related genes in parasites and host during murine experimental infection with Leishmania ( Leishmania ) 显示文摘 | Pereira B A Britto C Alves C R | 2012 | Microbial Pathogenesis2012，52，2： | 1 |
| 11 | On systems of elliptic equations involving subcritical or critical Sobolev exponents显示文摘 | Alves C O Filho D C de M Souto M A S | 2000 | Nonlinear Analysis2000，42，： | 1 |
| 12 | Parallel strategies for the local biological sequence alignment in a cluster of workstations显示文摘 | Boukerche A Alves de Melo A C M Ayala-Rincon M | 2007 | Journal of Parallel and Distributed Computing2007，67，2： | 1 |
| 13 | Quantitative analyses of kidney injury molecule -1messenger RNA in kidney transplant recipients with graft dysfunc-tion显示文摘 | Nogare A L Joelsons G Pedroso J A Veronese F J Gonalves L F Manfro R C | 2010 | Transplant Proc2010，42，： | 1 |
| 14 | End-to-end joining of tubes by plastic instability 显示文摘 | Alves L M Silva C M A Martins P A F | 2014 | Journal of Materials Processing Technology2014，214，9： | 1 |
| 15 | Quantitative study of caspase-3 activity in semen and after swim-up preparation in relation to sperm quality显示文摘 | Almeida C Cardoso MF Sousa M Viana P Gon(c)alves A Silva J | 2005 | Hum Reprod2005，20，5： | 1 |
| 16 | Theoretical optical parameters for Ⅲ-nitride semiconductors显示文摘 | Silva Pinto E de Paiva R de Carvalho L C Alves H W L Alves J L A | 2003 | Microelectronics Journal2003，34，： | 1 |
| 17 | Parameterized fast deeoupled power flow methods for obtaining the maximum loading point of power systems Part Ⅰ and Part Ⅱ显示文摘 | Alves D A Da Silva L C P Castro C A | 2004 | Electric Power Systems Research2004，69，： | 1 |
| 18 | Lean production as promoter of thinkers to achieve companies' agility 显示文摘 | Alves A C Dinis-Carvalho J Sousa R M | 2012 | The Learning Organiza- tion2012，19，3： | 1 |
| 19 | Changes in volatile com- position of Madeira wines during their oxidative ageing显示文摘 | Ci MARA J S ALVES M A MARQUES J C | 2006 | Anal Chim Acta2006，563，1： | 1 |
| 20 | Positive Solutions for a Quasilinear Elliptic Equation of Kirchhoff Type 显示文摘 | ALVES C O CORREA F J S A MAT F | 2005 | Comput Math Appl2005，49，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员