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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Hopf bifurcation for maps : a frequency - domain approach 显示文摘 | D'Amico M B Moiola J L Paolini E E | 2002 | IEEE Trans Circuits and Systems2002，49，： | 1 |
| 3 | Long-term results of Orthodontic treatment of impacted maxillary canines 显示文摘 | D'Amico RM Bjerklin K Kurol J | 2003 | Angle Orthod2003，73，3： | 1 |
| 4 | Epithelioid pituicy- toma显示文摘 | Ellis J A Tsankova N M D' Amico R | 2012 | World Neurosurg2012，78，12： | 1 |
| 5 | Psychosomatic Medicine显示文摘 | Grewen K M Girdler S S Amico J Light K C | 2005 | 67(4):5312005，67，4： | 1 |
| 6 | Gastric cancer clinical practice guidelines显示文摘 | Ajani J Bekaii-Saab T D'Amico TA | | 0，，04： | 1 |
| 7 | Effects of partner support on resting oxytocin, cortisol, norepinephrine, and blood pressure before and after warm partner contact 显示文摘 | Grewen KM Girdler SS Amico J | 2005 | Psy- chosoma Med2005，67，4： | 1 |
| 8 | A randomized clinical trial measuring the influence of kefir on antibiotic-associated diarrhea: the measuring the influence of kefir(MILK) sudy显示文摘 | Merenstein DJ Foster J D'Amico F | 2009 | Areh Pedi- atr Adolesc Med2009，163，8： | 1 |
| 9 | Carbon partitioning and sucrose metabolism in tomato plantsgrowing under salinity显示文摘 | Balibrea M E Dell'Amico J Bolarin M C Prrez-Alfocea F | 2000 | Physiologia Plantarum2000，110，4： | 1 |
| 10 | Pharmacological treatment of portal hypertension : an evidence - based approach 显示文摘 | D'Amico G Pagliaro L Bosch J | 1999 | Semin Liver Dis1999，19，4： | 1 |
| 11 | The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways 显示文摘 | D'Amico M Hulit J Amanatullah DF | 2000 | J Biol Chem2000，275，32： | 1 |
| 12 | Characterization of majorenzymes and genes involved in flavonoid and pro- anthocyanidin biosynthesis during fruit development in strawberry( Fragaria ananassa) 显示文摘 | Almeida J R D'amico E Preuss A | 2007 | Arch Biochem Bio- phys2007，465，1： | 1 |
| 13 | Retinal Toxicity of Intravitreal Gentamicin显示文摘 | D'Amico DJ Libert J Kenyon KR | 1984 | Invest Ophthalmol Vis Sci1984，25，5： | 1 |
| 14 | Pharmacological treatment of portal hypertension: an evidence based approach显示文摘 | D'Amico G Pagliaro L Bosch J | 1999 | Semin Liver Dis1999，19，： | 1 |
| 15 | The treatment of portal hyper-tension :a meta-analytic review显示文摘 | D′Amico G Pagliaro L Bosch J | 1995 | Hepatology1995，22，1： | 1 |
| 16 | The relationship-oriented in-formation-motivation-behavioral skills model : a multi-level structural equation model among dyads 显示文摘 | Harman J J Amico K R | 2009 | AIDSBehav2009，13，2： | 1 |
| 17 | A randomized clinical trialmeasuring the influence of kefir oil antibiotic-associated diarrhea:themeasuring the influence of Kefir(MILK)Study显示文摘 | MerenstoinDJ Foster J D’ Amico F | 2009 | Archives of Pediatricsand Adolescent Medicine2009，163，8： | 1 |
| 18 | Identification of intronic point mutations as an alternative mechanism for p53 inactivation in lung cancer显示文摘 | Takahashi T D' Amico D Chiba I Buchhagen D L Minna J D | 1990 | J Clin Invest1990，86，： | 1 |
| 19 | Efficacy of mediastinal lymph node dissection during lobectomy for lung cancer by thoracoscopy and thoracotomy显示文摘 | D'Amico TA Niland J Mamet R | 2011 | Ann Thorac Surg2011，92，： | 1 |
| 20 | Video-assisted thoracic surgery lobectomy:report of CALGB 39802--a prospective,multi-institution feasibility study显示文摘 | Swanson S J Herndon JE 2nd D′Amico TA | 2007 | JClin Oncol2007，25，31： | 1 |
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