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| 1 | Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs) are chronic disorders of modern society, requiring management strategies aimed at prolonging an active life and establishing the exact etiology and pathogenesis.These idiopathic diseases have environmental, genetic,immunologic, inflammatory, and oxidative stress components. On the one hand, recent advances have shown that abnormal immune reactions against the microorganisms of the intestinal flora are responsible for the inflammation in genetically susceptible individuals. On the other hand, in addition to T helper cell-type(Th) 1 and Th2 immune responses,other subsets of T cells, namely regulatory T cells and Th17 maintained by IL-23 are likely to develop IBD. IL-23 acts on innate immune system members and also facilitates the expansion and maintenance of Th17 cells. The IL-17/IL-23 axis is relevant in IBD pathogenesis both in human and experimental studies. Novel biomarkers of IBD could be calprotectin,microRNAs, and serum proinflammatory cytokines.An efficient strategy for IBD therapy is represented by the combination of IL-17 A and IL-17 F in acute IL-17 A knockout TNBS-induced colitis, and also definite decrease of the inflammatory process in IL-17 F knockout, DSS-induced colitis have been observed.Studying the correlation between innate and adaptive immune systems, we hope to obtain a focused reviewin order to facilitate future approaches aimed at elucidating the immunological mechanisms that control gut inflammation. | Cristina-Sorina Cǎanǎ Ioana Berindan Neagoe Vasile Cozma Cristian Magdas Flaviu Tǎbǎan Dan Lucian Dumitrasu | 2015 | World Journal of Gastroenterology2015，21，19： | 37 |
| 2 | Protocatechuic acid from Alpinia oxyphylla against MPP+-induced neurotoxicity in PC12 cells显示文摘 | An LJ Guan S Shi GF Bao YM Duan YL Jiang B | 2006 | 中国生物学文摘2006，20，10： | 30 |
| 3 | Protocatechuic acid suppresses MPP(+)-induced mitochondrial dysfunction and apoptotic cell death in PC12 cells.显示文摘 | Guan S Jiang B Bao YM An LJ | 2006 | 中国生物学文摘2006，20，10： | 17 |
| 4 | 25-羟维生素D和甲状旁腺激素与高血压的相关性显示文摘有研究证实,维生素D缺乏和甲状旁腺激素(PTH)过高与高血压的发生密切相关。维生素D缺乏不仅可以影响肾素血管紧张素系统及PTH水平,而且可以直接参与血管炎性反应,影响高血压的发生发展。PTH可以通过促进血管炎性反应及血管钙化等参与高血压的进展。目前还没有前瞻性研究同时评估维生素D和PTH水平与高血压发病的关系。该研究分析多民族动脉粥样硬化研究的前瞻性数据,发现低水平25羟维生素D[25(OH)D]和高水平PTH与高血压发病相关,特别是在肥胖人群中。但在校正混杂因素后,25(OH)D水平与高血压发病的相关性无统计学意义,而PTH水平与高血压发病仍然相关。鉴于维生素D缺乏和PTH过量在人群中是普遍现象,该研究对于更好地了解高血压发病机制,在人群中开展高血压预防工作有重要意义。 | van Ballegooijen AJ Kestenbaum B Sachs MC de Boer IH Siscovick DS Hoofnagle AN Ix JH Visser M Brouwer IA 练桂丽 叶鹏 | 2014 | 中华高血压杂志2014，22，6： | 10 |
| 5 | 血根碱对肉鸡生长性能、相对器官重量、盲肠菌群、血清胆固醇水平以及肉品质的影响显示文摘研究旨在探索日粮添加血根碱(SGV)对肉鸡生长性能、相对器官重量、盲肠菌群、血清胆固醇水平和腿肌丙二醛含量的影响。选用840日龄雄性肉鸡(罗斯品种)饲养于28个稻草垫上,随机分为4个处理:玉米-豆粕型基础对照日粮、基础日粮中添加卑霉素10 ppm作为生长促进剂(AGP)、基础日粮中添加SGV 20 ppm(SGV20)和50 ppm(SGV50)。与饲喂基础日粮的肉鸡相比,基础日粮中添加AGP组、SGV20组和SGV50组的肉鸡最终体重(BW)、日增重、饲料转化率(FCR)显著改善(P<0.05)。与对照组相比,SGV20喂养组的肉鸡相对空肠重量显著降低(P<0.05),所有添加SGV组肉鸡相对空肠或回肠长度显著升高(P<0.05)。SGV20组较对照组肉鸡肠道菌群有所改变,尤其是盲肠乳酸菌数增加,但AGP组无改变。SGV20组或SGV50组肉鸡的总胆固醇水平较对照组显著降低(P<0.05),控制饮食物显著降低(P<0.05)。添加SGV后,作为脂质过氧化反应指示剂的腿肌丙二醛含量显著降低(P<0.05)。研究表明,在肉鸡日粮中补充SGV 20或50 ppm可以提高肉鸡生长性能,改变多种生物和生理参数,如相对器官重量、血清胆固醇水平、肠道菌群和肉品质。 | Lee K W Kim J S Oh S T Kang C W An B K | 2015 | 饲料博览2015，0，3： | 2 |
| 6 | Cloning and identification of an angiostatic molecule IP-10/crg-2显示文摘AIM To obtain human and murine cDNAsencoding IFN--y inducible protein 10 (lP--10) andcytokine responsive gene--2 (Crg-2).METHODS The encoding genes of lP-10 and Crg2 were amplified by RT--PCR from Cultured humanfibroblast cells and Balb/ c mouse liver treatedby IFN-y and TNF-a, respectively, and clonedinto plasmids of PUC19 and PGEM3Zf(+ ).RESULTS The nucleotide sequences ot theamplified DNA were confirmed by endonucleasesdigestion and sequencing.CONCLUSION Recombinant lP-10/ crg--2 geneclones with 306 hp and 314 hp inserts wereestablished for further research on biologicalactivities and ligands of hiP-10/mCrg--2. | Liu ZG Yang JH An HZ Wang HY He FT Han ZY Han Y Wu HP Xiao B Fan DM | 1999 | World Journal of Gastroenterology1999，5，3： | 2 |
| 7 | 低氧血症对心肌声学造影评定冠脉储备的影响显示文摘目的 探讨低氧血症对心肌声学造影 (MCE)评定冠脉储备 (CFR)的影响。方法 对 9只非开胸猪进行心肌 MCE。取乳头肌水平短轴观 ,以 0 .5 ml/ min的速度连续滴注造影剂 Sonovue (BR1 )。每 1 5个心动周期进行一次破泡。破泡后的再充盈时间 -强度关系可用公式 Y=A (1 - e- bt) +c表示 ,依此可得到信号增加率 (b) ,以静息时的 b参数除滴注腺苷后的 b参数所得到的商为 CFR,进行氮气吸入前后的 CFR评定 ,并与荧光微球技术测得的心肌血流及 CFR进行对照。结果 氮气吸入前 2种方法所测得的 CFR相似 ,分别为 2 .5对 3.1 ,氮气吸入使平均氧分压明显降低 ,从 1 2 0 .6降到 5 1 .8mmHg (1 mm Hg=0 .1 33k Pa,下同 ;P<0 .0 0 1 ) ,心率由 1 1 4次 / min增加到 1 1 6次 / min,(P>0 .0 5 )。 CFR也明显降低 ,分别为 1 .5及 2 .5 ,这是由于氮气吸入后静息时的心肌血流轻微增加 ,而腺苷滴注后的心肌血流较氮气吸入前的心肌血流轻度降低所致。结论 氮气吸入导致的低氧血症降低 MCE所评定的 CFR值 ,当应用 MCE评定 CFR时 ,此生理变化的影响必须加以考虑。 | 杨源 李树清 Peters B De Maria AN | 2004 | 中国超声医学杂志2004，20，10： | 2 |
| 8 | Clinical evaluation of submucosal colonic lipomas: Decision making显示文摘甚至脂肪瘤是胃肠道的最普通的间充质的良性瘤,征兆的结肠的表示是稀罕的。此处,我们评估了受不了结肠的脂肪瘤的各种各样的尺寸的四个病人并且由不同治疗学的形式来临了。 | Oge Tascilar Güldeniz Karadeniz Cakmak Banu Dogan Gün Bülent Hamdi U(?)an Hakan Balbaloglu Ali Cesur Ali Ugur Emre Mustafa Comert Lütfü Oktay Erdem Selim Aydemir | 2006 | World Journal of Gastroenterology2006，12，31： | 2 |
| 9 | A serum glycomics approach to breast cancer biomarkers显示文摘 | Kirmiz C Li B An HJ | 2007 | Mol Cell Proteomics2007，6，1： | 1 |
| 10 | Multiwavelength operation of an erbium-doped fiber ring laser using a dual-pass Mach-zehnder comb filter 显示文摘 | Lin X Z Pun E Y B | 1999 | opt Commun1999，169，： | 1 |
| 11 | Action of corticosteroid to asthma on gene level显示文摘 | Kwon DJ Collins PD An B | 1993 | Am Rev Respir Dis1993，147，1： | 1 |
| 12 | State management methods for urban passenger transport system based on artificial system显示文摘 | Wang J An S Xie B | 2006 | Dynamics of Continuous Discrete and Impulsive Systems-Series B-Applications & Algorithms 132006，，： | 1 |
| 13 | Adsorption of 2,4,6-trinitrotoluene on a novel adsorption material PEI/SiO2 显示文摘 | An F Gao B J Feng X Q | 2009 | Journal of Hazardous Materials2009，166，23： | 1 |
| 14 | Pliocene uplift of the northern Tibetan Plateau显示文摘 | Zheng H B Powell C McA An Z S | 2000 | Geology2000，28，： | 1 |
| 15 | Normal Sleep Architecture in Infants and Children显示文摘 | Kahn A an B Groswasser | 1996 | J Clin Neurophysiology1996，13，3： | 1 |
| 16 | A novel drought-inducible gene,A TAF1,encodes a NAC family protein that negatively regulates the expression of stress-responsive genes in Arabidopsis显示文摘 | LU P L CH EN N Z AN R SU Z QI B S REN F CHEN J WANG X C | 2007 | Plant Molecular Biology2007，63，2： | 1 |
| 17 | Mapping metabolicbrain activation during human volitional swallowing: a posi-tron emission tomography study using fluorodeoxyglucose显示文摘 | Harris ML July an P Kulkami B | 2005 | J Cereb Blood Flow Metab2005，25，4： | 1 |
| 18 | Tlie sources of management innovation:fiims introduce new mananent practices 显示文摘 | MICHAEL J J UL I AN B | 2009 | Journal of Busi-ness Research2009，62，12： | 1 |
| 19 | Are CEOs Really Paid Like Bureaucrats显示文摘 | Hall B Liebm an J | | 0，，： | 1 |
| 20 | Effect of increased pCO2 on bacterial assemblage shifts in response to glucose addition in Fram Strait seawater mesocosms显示文摘 | Ray J L Topper B An S | | 0，，： | 1 |
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