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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Effect of antibiotic prophylaxis on the risk of surgical site infection in orthotopie liver transplant显示文摘 | Asensio A Ramos A Cuervas-Mons V | 2008 | Liver Transpl2008，14，6： | 1 |
| 3 | Living in towers as risk factor of pollen allergy显示文摘 | Armentia A Asensio T Subiza J | 2004 | Allergy2004，59，7： | 1 |
| 4 | Has evolution in awareness of guidelines for institution of damage control improved outcome in the management of posttraumatic open abdomen显示文摘 | Asensio J A Petrone P Roldan G | | 0，，02： | 1 |
| 5 | Effect of soil recla- mation process on soil C fractions显示文摘 | ASENSIO V VEGA F A COVELO E F | 2014 | Chemosphere2014，95，10： | 1 |
| 6 | Cocaine addiction: diffusion tensor imaging study of the inferior frontal and anterior cingulate white matter显示文摘 | Romero M] Asensio Sv Palau C Sanchez A Romero FJ | 2010 | Psychiatry Res2010，181，： | 1 |
| 7 | Live tuberculosis vaccines based on PhoP mutants: a step towards clinical trials显示文摘 | Asensio JA Arbues A Perez E | 2008 | Expert Opin Biol Ther2008，8，2： | 1 |
| 8 | Serum procalcintonin in children with suspected sepsis:a comparison with C-reactive protein and neutrophil count显示文摘 | Casad-Flores J Blanco-Quirós A Asensio J | 2003 | Pediatr Crit Care Med2003，4，2： | 1 |
| 9 | In-creasing rates in Clostridium difficile infection (CDI) among hospitalised patients, Spain 1999- 2007显示文摘 | Asensio A Vaque-Rafart J Calbo-Torrecillas F | 2008 | Euro Surveill2008，13，18： | 1 |
| 10 | Renal vascular injuries显示文摘 | Tillou A Romero J Asensio JA | 2001 | Surg Clin North Am2001，81，： | 1 |
| 11 | Crystalline polymorphism and molecular structure of sodium pravastatin 显示文摘 | Martin-Islan A P Cruzado M C Asensio R | 2006 | J Phys Chem B2006，110，51： | 1 |
| 12 | Nanage ment of duodenal injuries显示文摘 | ASENSIO J A FELICIANO D V BRIT L D | 1993 | Our Prob In Surg1993，30，： | 1 |
| 13 | Trends in yearly prevalence of third-generation eephalosporin and fluoro- quinolone resistant Enterobactefiaceae infections and antimicrobial use in Spanish hospitals, Spain, 1999 to 2010 显示文摘 | Asensio A Alvarez-Espejo T Fernandez-Crehuet J | 2011 | Euro Surveill2011，16，40： | 1 |
| 14 | Thermal treatment and foaming of chars obtained from almond shells kinetic study显示文摘 | Mareilla A Conesa J A Asensio M | 2000 | Fu- el2000，79，7： | 1 |
| 15 | Tree vegetation and waste amendments to improve the physical condition of copper mine soils显示文摘 | ASENSIO V VEGA F A ANDRADE M L COVELO E F | 2013 | Chemosphere2013，90，2： | 1 |
| 16 | Monoalkylatione of primary aromatic amine via N-(alkoxymethyl) arylamine显示文摘 | Barluenga J Bayon A M Asensio G | 1983 | J Chem Soc Chem Commun1983，19，： | 1 |
| 17 | Clinical findings as predictors of positivity of head-up tilt table test in neurocardiogenic syncope显示文摘 | Asensio E Oseguera J Loria A | 2003 | Arch Med Res2003，34，4： | 1 |
| 18 | Outbreak of a multiresistant Klebsiella pneumoniae strain in a intensive care unit: Antibiotic use as a risk factor for colonization and infection显示文摘 | Asensio A Oliver A Gonzalez-Diego P | 2000 | Clin Infect Dis2000，30，： | 1 |
| 19 | Electrocardiographic abnormalities in patients with acute pancreatitis显示文摘 | Rubio A Garcia J Asensio E | 2005 | J Clin Gastroenterol2005，39，9： | 1 |
| 20 | 查看详情显示文摘 | Asensio A Kobko N Dannenberg J. J | | 0，，： | 1 |
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