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| 1 | Prognostic role of sensitive-to-apoptosis gene expression in rectal cancer显示文摘AIM:To investigate the association between prognosis of rectal cancer treated with chemoradiotherapy(CRT) and expression of sensitive-to-apoptosis(SAG),B-cell lymphoma-extra large(Bcl-X L) and Bcl-2 homologous antagonist/killer(Bak).METHODS:Real-time quantitative polymerase chain reaction was used to determine the expression of proteins of interest,namely SAG,Bcl-X L,Bak and β-actin,in rectal carcinoma patients who had a follow-up period of 3 years after CRT.Biopsy specimens were excised from the rectal tumor preceding CRT.RESULTS:SAG,Bcl-X L and Bak proteins showed significant correlations with each other.In multivariate analysis,patients with high vs low SAG expression showed a statistically significant difference in 2-year survival rates:56% vs 73%,respectively(P = 0.056).On the other hand,there were no significant correlations between the expression levels of all three genes and metastatic rates or tumor responses to CRT.Mean overall survival in the patients with elevated SAG expression was 27.1 mo ± 3.9 mo [95% confidence interval(CI):19.3-34.9],and in patients with reduced expression,it was 32.1 mo ± 2.5 mo(95% CI:27.3-36.9).The corresponding values for Bcl-X L were 28.0 mo ± 4.1 mo(95% CI:19.9-36.1) and 31.7 mo ± 2.9 mo(95% CI:26.0-37.5),and those for Bak were 29.8 mo ± 3.7 mo(95% CI:22.5-37.2) and 30.6 mo ± 2.4 mo(95% CI:25.5-35.0),respectively.CONCLUSION:Two-year survival rates significantly correlated with low SAG expression,and SAG may be a candidate gene for good prognosis,independent of therapeutic response of different individuals. | Sevgi A Ozden Hazan Ozyurt Zerrin Ozgen Olca Kilinc Mustafa Oncel Aylin E Gul Nimet Karadayi Nedime Serakinci Beki Kan Oya Orun | 2011 | World Journal of Gastroenterology2011，17，44： | 6 |
| 2 | An evaluation of internal carotid artery and cerebral blood flow volume using color duplex sonography in patients with vertebral artery hypoplasia显示文摘 | MURAT A BUMIN D AYLIN Y | 2005 | European Journal of Radiology2005，53，： | 1 |
| 3 | Effects of lesion complexity on baseline and post procedural B-type natriuretic peptide levels in patients undergoing percutaneous coronary interventions 显示文摘 | Aylin Y Sadik A Cagatay E | 2007 | Tex Heart Inst J2007，34，8： | 1 |
| 4 | Short - term outcomes fol- lowing open versus minimally invasive esophagectomy for cancer in England: A population - based national study显示文摘 | Mamidanna R Bottle A Aylin P | 2012 | Ann Surg2012，255，： | 1 |
| 5 | Mortality associated with delay in operation afterhip fracture: observational study 显示文摘 | Bottle A Aylin P | 2006 | BMJ2006，332，7547： | 1 |
| 6 | Environment toxins and endometriosis 显示文摘 | Hulusi BZ Aylin A David LO | 1997 | Obstet Gynecol Clin Nor Am1997，24，： | 1 |
| 7 | Mortality associated with delay in operation after hip fracture:observational study显示文摘 | Bottle A Aylin P | 2006 | BMJ2006，332，7547： | 1 |
| 8 | Mortality associated with delay in operation after hip fracture : observational study 显示文摘 | Bottle A Aylin P | 2006 | BMJ2006，332，7547： | 1 |
| 9 | Mortality associated with delay in operation after hip fracture : observational study 显示文摘 | Bottle A Aylin P | 2006 | BMJ2006，332，7547： | 1 |
| 10 | J-ngth of hospital stay and subsequent emergency readmission显示文摘 | WILLIAMS S BOTTLE A AYLIN P | 2005 | BMJ2005，331，： | 1 |
| 11 | Effects of lesion complexity on baseline and postprocedural B type natriuretic peptide levels in patients undergoin percutaneous coronary interventions显示文摘 | AYLIN Y SADIK A CAGATAY E | 2007 | Tex Heart Inst J2007，34，： | 1 |
| 12 | Aggregation and thermodynamic properties of some cationic Gemini surfactants 显示文摘 | Halide A Aylin E I Mesut B | 2011 | J Surfact Deterg2011，15，1： | 1 |
| 13 | Effects of lesion complexity on baseline and postproeedural B- type natriuretic peptide levels in patients undergoing percutaneous coronary interventions 显示文摘 | AYLIN Y SADIK A CAGATAY E | 2007 | Tex Heart Inst J2007，34，： | 1 |
| 14 | Comparison of three commonly used cytologic preparation in effusion immunocytochemistry显示文摘 | Patricia A F Aylin S Keith B | 2002 | Diagn Cytooathol2002，26，1： | 1 |
| 15 | Mortality associated with delay in operation after hip fracture:observational study显示文摘 | Bottle A Aylin P | 2006 | BMJ2006，332，： | 1 |
| 16 | Short-term outcomes fol- lowing open versus minimally invasive esophagectomy for cancer in England: a population-based national study显示文摘 | Mamidanna R Bottle A Aylin P | 2012 | Ann Surg2012，255，2： | 1 |
| 17 | Comparison of vertebral artery velocity and flow volume measurements for diagnosis of vertebrobasilar insufficiency using color duplex sonography 显示文摘 | Murat A Bumin D Aylin Y | 2005 | Eur J Radiol2005，54，： | 1 |
| 18 | Short-term outcomes following open versus minimally invasive esophagectomy for cancer in England: a population-based national study显示文摘 | Mamidanna R Bottle A Aylin P | 2012 | Ann Surg2012，255，2： | 1 |
| 19 | Effects of lesion com- plexity on baseline and postprocedural B-type natriuretic peptide levels in patients undergoing percutaneous coro-nary interventions 显示文摘 | Aylin Y Sadik A Cagatay E | 2007 | Tex Heart Inst J2007，34，3： | 1 |
| 20 | Short-term outcomes following open versus minimally invasive esophagectomy for cancer in England:a population-based national study显示文摘 | Mamidanna R Bottle A Aylin P | 2012 | Ann Surg2012，255，2： | 1 |
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