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| 1 | Inflammatory bowel disease: A descriptive study of 716 local Chilean patients显示文摘AIM: To demographically and clinically characterize inflammatory bowel disease(IBD) from the local registry and update data previously published by our group.METHODS: A descriptive study of a cohort based on a registry of patients aged 15 years or older who were diagnosed with IBD and attended the IBD program at Clínica Las Condes in Santiago, Chile. The registry was created in April 2012 and includes patients registered up to October 2015. The information was anonymously downloaded in a monthly report, and the information on patients with more than one visit was updated. The registry includes demographic, clinical and disease characteristics, including the Montreal Classification, medical treatment, surgeries and hospitalizations for crisis. Data regarding infection with Clostridium difficile(C. difficile) were incorporated in the registry in 2014. Data for patients who received consultations as second opinions and continued treatment at this institution were also analyzed. RESULTS: The study included 716 patients with IBD: 508 patients(71%) were diagnosed with ulcerative colitis(UC), 196 patients(27%) were diagnosed with Crohn's disease(CD) and 12 patients(2%) were diagnosed with unclassifiable IBD. The UC/CD ratio was 2.6/1. The median age was 36 years(range 16-88), and 58% of the patients were female, with a median age at diagnosis of 29 years(range 5-76). In the past 15 years, a sustained increase in the number of patients diagnosed with IBD was observed, where 87% of the patients were diagnosed between the years 2001 and 2015. In the cohort examined in the present study, extensive colitis(50%) and colonic involvement(44%) predominated in the patients with UC and CD, respectively. In CD patients, nonstricturing/non-penetrating behavior was more frequent(80%), and perianal disease was observed in 28% of the patients. There were significant differences in treatment between UC and CD, with a higher use of corticosteroids, and immunosuppressive and biological therapies was observed in the patients with CD(P < 0.05 and P < 0.01). Significant surgical differences were also observed: 5% of the UC patients underwent surgery, whereas 38% of the CD patients required at least one surgery(P < 0.01). The patients with CD were hospitalized more often during their disease course than the patients with UC(55% and 35% of the patients, respectively; P < 0.01). C. difficile infection was acquired by 5% of the patients in each group at some point during the disease course. Nearly half of the patients consulted at the institution for a second opinion, and 32% of these individuals continued treatment at the institution. CONCLUSION: IBD has continued to increase in the study cohort, slowly approaching the level reported in developed countries. | Daniela Simian Daniela Fluxá Lilian Flores Jaime Lubascher Patricio Ibánez Carolina Figueroa Udo Kronberg Raúl Acuna Mauricio Moreno Rodrigo Quera | 2016 | World Journal of Gastroenterology2016，22，22： | 2 |
| 2 | Muhidetector computed tomography angiography of the abdomen显示文摘 | Gtiven K Acunas B | 2004 | Eur J Radiol2004，52，1： | 1 |
| 3 | Practical limitations of near-field goniophotometer measurements imposed by a dynamic range mismatch显示文摘 | AUDENAERT J ACUNA P HANSELAER P | 2015 | Optics Express2015，23，3： | 1 |
| 4 | Amoxicillin-Sulbac- tam: A clinical and therapeutic review 显示文摘 | ACUNA C RABASSED X | 2001 | Drugs Today2001，37，3： | 1 |
| 5 | The magnetic field of Mars 显示文摘 | Acuna M H | 2003 | The Leading Edge2003，22，8： | 1 |
| 6 | Imaging of extrapulmonary tuberculosis 显示文摘 | Engin G Acunas B Acunas G | 2000 | Radiographics2000，20，2： | 1 |
| 7 | Synthesis of MoS2 nanorods and their catalytic test in the HDS of dibenzothiophene 显示文摘 | Albiter M A Huirache Acuna R Paraguay-Delgado F | 2006 | Nanotechnology2006，17，14： | 1 |
| 8 | Tectonic implica- tions of Mars crustal magnetism显示文摘 | Connemey J E P Acuna M H Ness N F | 2005 | Proceedings of the National A- cademy of Sciences USA2005，102，14： | 1 |
| 9 | Recurrence and out- comes of Stevens-Johnson syndrome arld toxic epidermal necroly- sis in children显示文摘 | Finkelstein Y Soon GS Acuna P | 2011 | Pediatrics2011，128，4： | 1 |
| 10 | Use of near infrared spectroscopy and multivariate analysis to predict wood density of Douglas-fir from chain saw chips显示文摘 | Acuna M A Murphy G E | 2006 | Forest Products Jottmal2006，56，1112： | 1 |
| 11 | Neuron-specific enolase as a marker of the severity and outcome of hypoxic ischemic encephalopathy显示文摘 | Celtik C Acunas B Oner N | 2004 | Brain Dev2004，26，6： | 1 |
| 12 | Neuron-specific enolase as a marker of the severity and outcome of hypoxic ischemic encephalopathy显示文摘 | Celtik C Acunas B Oner N | 2004 | Brain Dev2004，26，6： | 1 |
| 13 | Air pollution and brain damage显示文摘 | Calderon-Garcidueas L Azzarelli B Acuna H | 2002 | Toxicol Pathol2002，30，3： | 1 |
| 14 | Multidetector computed tomography angiography of the abdomen 显示文摘 | Guven K Acunas B | 2004 | Eur J Radiol2004，52，1： | 1 |
| 15 | New world hantaviruses activate IFN lambda production in type I IFN - deficient vero E6 cells 显示文摘 | Prescott J Hall P Acuna - Retamar M | 2010 | PLoS One2010，5，11： | 1 |
| 16 | Neuron-specifice nolase as a marker of the severity and outcome of hypoxic ischemic encephalopathy显示文摘 | Celtik C Acunas B Oner N | 2004 | Brain Dev2004，26，6： | 1 |
| 17 | Imaging of extrapulmonary tuberculosis显示文摘 | Engin G Acunas B Acunas G | 2000 | Radiographics2000，20，2： | 1 |
| 18 | Urologic injuries associated with repair of anorectal malformation in male patients显示文摘 | Hong AR Acuna MF Pefia A | 2002 | J Pediatr Surg2002，37，3： | 1 |
| 19 | Hepatocellular carcinoma: treatment with transcatheter arterial chemoembolization显示文摘 | Acunas B Rozanes I | 1999 | Eur J Radiol1999，32，1： | 1 |
| 20 | Percutaneous endoscopic gastrostomy:the technique of choice?显示文摘 | SAITUA F ACUNA R HERRERA P | 2003 | J Pediatr Surg2003，38，： | 1 |
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