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| 1 | Kefir treatment ameliorates dextran sulfate sodium-induced colitis in rats显示文摘AIM: To investigate the preventive effect of kefir on colitis induced with dextran sulfate sodium(DSS) in rats.METHODS: Twenty-four male Wistar-albino rats were randomized into four groups: normal control,kefircontrol,colitis,and kefir-colitis groups. Rats in the normal and kefir-control groups were administered tap water as drinking water for 14 d. Rats in the colitis and kefir-colitis groups were administered a 3% DSS solution as drinking water for 8-14 d to induce colitis. Rats in the kefir-control and kefir-colitis groups were administered 5 m L kefir once a day for 14 d while rats in the normal control and colitis group were administered an identical volume of the placebo(skim milk) using an orogastric feeding tube. Clinical colitis was evaluated with reference to the disease activity index(DAI),based on daily weight loss,stool consistency,and presence of bleeding in feces. Rats were sacrificed on the 15 th day,blood specimens were collected,and colon tissues were rapidly removed. Levels of myeloperoxidase(MPO),tumor necrosisfactor(TNF)-α,interleukin(IL)-10,malondialdehyde,and inducible nitric oxide synthase(i NOS) were measured in colon tissue.RESULTS: The DAI was lower in the kefir-colitis group than in the colitis group(on the 3rd and 5th days of colitis induction; P < 0.01). The DAI was also significantly higher in the colitis group between days 2 and 6 of colitis induction when compared to the normal control and kefir-control groups. The DAI was statistically higher only on the 6th day in the kefircolitis group when compared to that in the normal control groups. Increased colon weight and decreased colon length were observed in colitis-induced rats. Mean colon length in the colitis group was significantly shorter than that of the kefir-control group. Kefir treatment significantly decreased histologic colitis scores(P < 0.05). MPO activity in the colitis group was significantly higher than in the kefir-control group(P < 0.05). Kefir treatment significantly reduced the DSS colitis-induced TNF-α increase(P < 0.01). No statistically significant differences were observed among groups for IL-10 and MDA levels. Colon tissue i NOS levels in the colitis group were significantly higher than those in the control and kefir-colitis groups(P < 0.05).CONCLUSION: Kefir reduces the clinical DAI and histologic colitis scores in a DSS-induced colitis model,possibly via reduction of MPO,TNF-α,and i NOS levels. | Altug Senol Mehmet Isler Recep Sutcu Mete Akin Ebru Cakir Betul M Ceyhan M Cem Kockar | 2015 | World Journal of Gastroenterology2015，21，46： | 3 |
| 2 | 机械循环支持流感病毒相关心肌炎所致难治性心源性休克显示文摘机械循环辅助在流感病毒相关心肌炎合并难治性心源性休克(rCS)的应用仍缺乏证据。本研究为基于近两个流感流行季的单中心、前瞻性、观察性研究。目的为观察应用静脉‐动脉体外膜肺氧合(V‐A ECMO)和心室辅助系统进行联合机械循环辅助对流感相关心肌炎合并rCS患者的影响。 | Sieweke JT Akin M Stetskamp S 孙兵 唐晓 | 2021 | 中华医学杂志2021，101，8： | 3 |
| 3 | Evaluation of bone turnover in postmenopausal patients with type 2 diabetes mellitus using biochemical markers and bone mineral density measurements显示文摘 | Akin O Gol K Akturk M | 2003 | Gynecol Endocrinol2003，17，1： | 1 |
| 4 | Sympathetic skin response and R-R interval variation in rheumatoidarthritis: two simpie tests for the assess ment of autonomic function 显示文摘 | Tan J Akin S Beyazova M | 1993 | Am J phys reed Rehabil1993，72，： | 1 |
| 5 | Effect of monensin in lactating dairy cow diets at 2starch concentrations显示文摘 | Akins M S Perfield K L Green H B | 2014 | J Dairy Sci2014，97，： | 1 |
| 6 | An adaptive artificial immune system for fault classification 显示文摘 | Aydin I Karakose M Akin E | 2012 | Journal of Intelligent Manufacturing (S0956-5515)2012，23，5： | 1 |
| 7 | Bactericidal activities of two daptomycin regimens against clinical strains of glycopeptide intermediate-resistant Staphylococcus aureus,vancomycin-resistant Enterococcus faecium,and methicillin-resistant Staphylococcus aureus isolates in an in vitro phar显示文摘 | Akins R L Rybak M J | | 0，，： | 1 |
| 8 | Untreated growing cranial fractures detected in late stage显示文摘 | Kutlay M Demircan N Akin ON | 1998 | Neurosurgery1998，43，： | 1 |
| 9 | PET-CT findings in large vessel vasculitis presenting as FUO,a case report显示文摘 | Akin E Coen A Momeni M | | 0，，06： | 1 |
| 10 | Comparison of the effects of sodium nitroprusside and L-carnitine in experimental ischemia-reperfusion injury in rats显示文摘 | AKIN M KURUKAHVECIOGLU O GULBAHAR O | 2007 | Transplant Proc2007，39，10： | 1 |
| 11 | Optimization for enzymeretting of flax with pectate lyase显示文摘 | AKIN D E CONDIN B SOHN M | 2007 | Industrial Crops and Products2007，25，： | 1 |
| 12 | Automatic Recognition of Alertness Level by Using Wavelet Transform and Artificial Neural Network 显示文摘 | Kiymik M K Akin M Subasi A | 2004 | Journal of Neuroscience Methods2004，139，2： | 1 |
| 13 | SHBG levels correlatewith insulin resistance in postmenopausal women显示文摘 | Akin F Bastemir M Alkis E | 2009 | Eur JIntern Med2009，20，2： | 1 |
| 14 | Laparoscopic hernioraphy:a better approach for recurrent hernia in boys?显示文摘 | Yildiz A ?elebi S Akin M | 2012 | Pediatr Surg Int2012，28，5： | 1 |
| 15 | Comparison oflaparoscopic and open surgery for total rectal prolapse显示文摘 | Demirbas S Akin ML Kalemoglu M | 2005 | Surg Today2005，35，6： | 1 |
| 16 | The endocrine disruptor bisphenol A may play a role in the aetiopathogenesis of polycystic ovary syndrome in adolescent girls显示文摘 | Akin L Kendirci M Narin F | 2015 | Acta Paediatr2015，104，4： | 1 |
| 17 | Utilizing image texture to detect land-cover change in Mediterranean coastal wetlands显示文摘 | Berberoglu S Akin A Atkinson P M | 2010 | In- ternational Journal of Remote Sensing2010，31，11： | 1 |
| 18 | Fully automatic segmentation of the brain in MRI显示文摘 | Akins M S Mackiewish B T | 1998 | IEEE Trans Medical Imaging1998，17，1： | 1 |
| 19 | Automatic recognition of vigilance state by using a wavelet-based artiflcial neural network显示文摘 | Subasi A Kiymik M K Akin M | 2005 | Neural Comput & Applic2005，14，1： | 1 |
| 20 | Crossed testicular ectopia: report of six cases显示文摘 | Akin M Erginel B Bilicil S | 2014 | Afr J Paediatr Surg2014，11，： | 1 |
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