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| 1 | Does autologous blood transfusion during liver transplantation for hepatocellular carcinoma increase risk of recurrence?显示文摘AIM: To analyze outcomes in patients who underwent liver transplantation(LT) for hepatocellular carcinoma(HCC) and received autologous intraoperative blood salvage(IBS). METHODS: Consecutive HCC patients who underwent LT were studied retrospectively and analyzed according to the use of IBS or not. Demographic and surgical data were collected from a departmental prospective maintained database. Statistical analyses were performed using the Fisher's exact test and the Wilcoxon rank sum test to examine covariate differences between patients who underwent IBS and those who did not. Univariate and multivariate Cox regression models were developed to evaluate recurrence and death,and survival probabilities were estimated using the Kaplan-Meier method and compared by the log-rank test.RESULTS: Between 2002 and 2012,158 consecutive patients who underwent LT in the same medical center and by the same surgical team were identified. Among these patients,122(77.2%) were in the IBS group and 36(22.8%) in the non-IBS group. The overall survival(OS) and recurrence free survival(RFS) at 5 years were 59.7% and 83.3%,respectively. No differences in OS(P=0.51) or RFS(P=0.953) were detected between the IBS and non-IBS groups. On multivariate analysis for OS,degree of tumor differentiation remained as the only independent predictor. Regarding patients who received IBS,no differences were detected in OS or RFS(P=0.055 and P=0.512,respectively) according to the volume infused,even when outcomes at 90 d or longer were analyzed separately(P=0.518 for both outcomes).CONCLUSION: No differences in RFS or OS were detected according to IBS use. Trials addressing this question are justified and should be designed to detect small differences in long-term outcomes. | Raphael LC Araujo Carlos Andrés Pantanali Luciana Haddad Joel Avancini Rocha Filho Luiz Augusto Carneiro D’Albuquerque Wellington Andraus | 2016 | World Journal of Gastrointestinal Surgery2016，8，2： | 14 |
| 2 | Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis显示文摘AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis. | Giliane Belarmino Maria Cristina Gonzalez Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani Steven B Heymsfield Dan L Waitzberg | 2017 | World Journal of Hepatology2017，9，7： | 11 |
| 3 | Serum proinflammatory cytokines and nutritional status in pediatric chronic liver disease显示文摘AIM: To evaluate the nutritional status and its association with proinflammatory cytokines in children with chronic liver disease.METHODS: We performed a cross-sectional study with 43 children and adolescents, aged 0 to 17 years, diagnosed with chronic liver disease. All patients regularly attended the Pediatric Hepatology Unit and were under nutritional follow up. The exclusion criteria were fever from any etiology at the time of enrollment, inborn errors of the metabolism and any chronic illness. The severity of liver disease was assessed by Child-Pugh, Model for End-stage Liver Disease(MELD) and Pediatric End Stage Liver Disease(PELD) scores. Anthropometric parameters were height/age, body mass index/age and triceps skinfold/age according to World Health Organization standards. The cutoff points for nutritional status were risk of malnutrition(Z-score <-1.00) and malnutrition(Z-score <-2.00). Interleukin-1β(IL-1β), IL-6 and tumor necrosis factor-α levels were assessed by commercial ELISA kits. For multivariate analysis, linear regression was applied to assess the association between cytokine levels, disease severity and nutritional status. RESULTS: The median(25th-75 th centile) age of the study population was 60(17-116)-mo-old, and 53.5% were female. Biliary atresia was the main cause of chronic liver disease(72%). With respect to Child-Pugh score, cirrhotic patients were distributed as follows: 57.1% Child-Pugh A, a mild presentation of the disease, 34.3% Child-Pugh B, a moderate stage of cirrhosis and 8.6% Child-Pugh C, were considered severe cases. PELD and MELD scores were only above the cutoff point in 5 cases. IL-6 values were increased in patients at nutritional risk(34.9%) compared with those who were well-nourished [7.12(0.58-34.23) pg/m L vs 1.63(0.53-3.43) pg/m L; P = 0.02], correlating inversely with triceps skinfold-for-age z-score(rs =-0.61; P < 0.001). IL-6 levels were associated with liver disease severity assessed by Child-Pugh score(P = 0.001). This association remained significant after adjusting for nutritional status in a linear regression model. CONCLUSION: High IL-6 levels were found in children with chronic liver disease at nutritional risk. Inflammatory activity may be related to nutritional status deterioration in these patients. | Daniele Santetti Maria Inês de Albuquerque Wilasco Cristina Toscani Leal Dornelles Isabel Cristina Ribas Werlang Fernanda Urruth Fontella Carlos Oscar Kieling Jorge Luiz dos Santos Sandra Maria Goncalves Vieira Helena Ayako Sueno Goldani | 2015 | World Journal of Gastroenterology2015，21，29： | 2 |
| 4 | Helicobacter pylori Induces Increased Expression of Toll‐Like Receptors and Decreased Toll‐Interacting Protein in Gastric Mucosa that Persists Throughout Gastric Carcinogenesis显示文摘 | Pedro Pimentel‐Nunes Nádia Gon?alves Inês Boal‐Carvalho Luís Afonso Paula Lopes Roberto Roncon‐Albuquerque Rui Henrique Luís Moreira‐Dias Adelino F. Leite‐Moreira Mário Dinis‐Ribeiro | 2012 | Helicobacter2012，，1： | 2 |
| 5 | Transesterification of ethyl butyrate with methanol using MgO/CaOcatalyst 显示文摘 | ALBUQUERQUE M C G AZEVEDO D C S CAVALCANTE C L | 2009 | Journal of Molecular Catalysis A : Chemical2009，300，12： | 1 |
| 6 | Trends in the analytical methods for the determinationof trans fatty acids content in foods显示文摘 | ALBUQUERQUE T G COSTA H S CASTILHO M C | 2011 | Trends in Food Scienceand Technology2011，22，11： | 1 |
| 7 | Structural analysis and optimization in the framework ofreduced-basis method 显示文摘 | Afonso S M B Lyra P R M Albuquerque T M M | 2010 | Structural andMultidisciplinary Optimization2010，40，16： | 1 |
| 8 | Outcome of oculomotor nerve palsy from posterior communicating artery aneurysms:comparison of clipping and coiling显示文摘 | Chen PR Amin-Hanjani S Albuquerque FC | 2006 | Neurosurgery2006，58，6： | 1 |
| 9 | Simultaneous-integrated boost intensity-modulated radiation therapy(SIB-IMRT)in the treatment of early-stage left-sided breast carcinoma显示文摘 | Singla R King S Albuquerque K | 2006 | Med Dosimetry2006，31，3： | 1 |
| 10 | Simultaneous-inte- grated boost intensity-modulated radiation therapy (SIPrIM- RT) in the treatment of early-stage left-sided breast carcinoma显示文摘 | Singla R King S Albuquerque K | 2006 | Med Dosim2006，31，3： | 1 |
| 11 | New insights into HLA-G mediated tolerance显示文摘 | Amodio G Sales De Albuquerque R Gregori S | 2014 | Tissue Antigens2014，84，3： | 1 |
| 12 | Structure and magnetic properties of nanostructured Ni-ferrite显示文摘 | Albuquerque A S Ardisson J D Macedo W A A | 2001 | J Magn Magn Mater2001，，： | 1 |
| 13 | Outcome of oculomotor nerve palsy from posterior communicating artery aneurysms: comparison of clipping and coiling 显示文摘 | Chen PR Amin-Hanjani S Albuquerque FC | 2006 | Neurosurgy2006，58，6： | 1 |
| 14 | Successful liver allograft inflow reconstruction with the right gastroepiploic vein显示文摘Portal vein thrombosis is a common complication in cirrhotic patients. When portal vein thrombectomy is not a suitable option, a large collateral vessel can be used for allograft venous inflow reconstruction. We describe an unusual case of successful portal revascularization using the right gastroepiploic vein. The patient underwent a cadaveric orthotopic liver transplantation with end-to-end anastomosis of the portal vein to the right gastroepiploic vein. Six months after liver transplantation the patient is well with good liver function. The use of the right gastroepiploic vein for allograft venous reconstruction is feasible and safe, with a great advantage of avoiding the need of venous jump graft. | Rafael S Pinheiro Ruy J Cruz Jr Lucas S Nacif Matheus F Vane Luiz AC D'Albuquerque | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，1： | 1 |
| 15 | Coagulation of indigo blue present in dying wastewater using a residual bittern显示文摘 | ALBUQUERQUE L F SALGUEIRO A A MELO J L D S | | 0，，： | 1 |
| 16 | Coagulation of indigo blue presem in dyeing wastewater using a residual bittern显示文摘 | ALBUQUERQUE L F SALGUEIRO A A MELO J L d S | 2013 | Separation and Purification Technology2013，104，： | 1 |
| 17 | Efficient supervised optimum-path forest classification for large datasets显示文摘 | J P Papa A X Falc o V H C de Albuquerque J M R S Tavares | 2012 | Pattern Recognition2012，45，1： | 1 |
| 18 | Nanosized powders of NiZn ferrite: Synthesis, structure, and magnetism 显示文摘 | Albuquerque A S Arsisson J D Macedo W A A | 2000 | J Appl Phys2000，87，9： | 1 |
| 19 | FY polymorphisms and vivax malaria in inhabitants of Amazonas State, Brazil显示文摘 | Sérgio Roberto Lopes Albuquerque Francimary Oliveira Cavalcante Edalton Cesar Sanguino Lucianna Tezza Fernanda Chacon Lilian Castilho Maria Cristina Santos | 2010 | Parasitology Research2010，，5： | 1 |
| 20 | Multimarker a-nalysis of circulating tumor cells in peripheral blood ofmetastatic breast cancer patients:a step forward in per-sonalized medicine显示文摘 | de Albuquerque A Kaul S Breier G | 2012 | Breast Care (Basel)2012，7，1： | 1 |
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