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| 1 | Liver histology in ICU patients dying from sepsis:A clinico-pathological study显示文摘AIM:To determine end-stage pathologic changes in the liver of septic patients dying in the intensive care unit. METHODS: Needle liver biopsies obtained immediately after death from 15 consecutive patients with sepsis and no underlying liver disease were subjected to routine histological examination. Liver function tests and clinical monitoring measurements were also recorded. RESULTS: Liver biochemistries were increased in the majority of patients before death. Histology of liver bi- opsy specimens showed portal inflammation in 73.3%, centrilobular necrosis in 80%, lobular inflammation in 66.7%, hepatocellular apoptosis in 66.6% and cholan- gitis/cholangiolitis in 20% of patients. Mixed hepatitic/ cholestatic type of liver injury was observed in 6/15 (40%) patients and hepatitc in 9/15 (60%). Steatosis was ob- served in 11/15 (73.3%) patients affecting 5%-80% of liver parenchyma. Among the histological features, the presence of portal inflammation in liver biopsy was as- sociated with increased hospitalization in the ICU prior death (P = 0.026). CONCLUSION: Features of hepatitis and steatosis arethe main histological findings in the liver in the majority of patients dying from sepsis. | John Koskinas Ilias P Gomatos Dina G Tiniakos Nikolaos Memos Maria Boutsikou Aspasia Garatzioti Athanasios Archimandritis Alexander Betrosian | 2008 | World Journal of Gastroenterology2008，14，9： | 8 |
| 2 | 使用二甲双胍的禁忌证 证据显示应该修改二甲双胍的禁忌证显示文摘在英国前瞻性糖尿病研究(UNPOS)中,2型糖尿病患者被随机分入二甲双胍、磺酰脲类或胰岛素强化治疗组,3组患者取得了相似的血糖控制效果,微血管并发症终点事件显著降低。该项研究显示,肥胖患者使用二甲双胍治疗可以降低心血管事件的发生,二甲双胍治疗组的患者没有低血糖事件。 | G C Jones J P Macklin W D Alexander 李玉秀 | 2003 | 英国医学杂志中文版2003，6，3： | 2 |
| 3 | Deep venous thrombosis and pulmonary embolism: Diagnosis, prophylaxis, and treatment 显示文摘 | Alexander P Giangola G | 1999 | Ann Vas Surg1999，13，3： | 1 |
| 4 | Spectral calibration of the EO-1 advanced land imager显示文摘 | Jeffrey G A Alexander P C | 1999 | SPIE1999，3750，： | 1 |
| 5 | Water-Graphite interaction and behavior of water near the graphite surface 显示文摘 | Alexander P Michael G | 2004 | The Journal of Physics Chemistry B2004，108，： | 1 |
| 6 | Plastic cup traps equipped with light-emitting diodes for monitoring adult Bemisiatabaci (Homoptera; Aleyrodi- dae)显示文摘 | Chu Changchi Jackson C G Alexander P J | 2003 | Journal of Economic Entomology2003，96，： | 1 |
| 7 | Antigenic and biological characterisatien of avian paramyxovirus type Ⅰ isolates from pigenns-an international collaborative study显示文摘 | Alexander D J Russell P H Parsons G | 1985 | Avian Pathol1985，14，： | 1 |
| 8 | Deep venous thrombosis and pulmonary embolism: diagnosis, prophylaxis,and treatment显示文摘 | ALEXANDER P GIANGOLA G | 1999 | Ann Vasc Surg1999，13，3： | 1 |
| 9 | Steel Corrosion on RC Structures under Sustained Service Loads A Critical Review显示文摘 | Malumbela G Alexander M Moyo P | 2009 | Engineering Structures2009，31，11： | 1 |
| 10 | Antigenic and biological characterization of avian paramyxovirus type 1 isolates from pigeons-an international collaborative study显示文摘 | Alexander D J Russell P H Parsons G | 1985 | Avian Pathol1985，14，： | 1 |
| 11 | Antigenic and biological characterization of paramyxovirus type Ⅰ isolates from pigeons:an international collaborative study显示文摘 | Alexander D J Russell P H Parsons G | 1985 | Avian Pathology1985，14，： | 1 |
| 12 | Lateral Deform- ation of RC Beams under Simultaneous Load and Steel Corrosion 显示文摘 | Malumbela G Alexander M Moyo P | 2010 | Construction and Building Materials2010，24，1： | 1 |
| 13 | A comprehensive map of the porcine genome 显示文摘 | Rohrer G A Alexander L J Hu Z Smith T P L Keele JW Beattie C W | 1996 | Genome Res1996，6，： | 1 |
| 14 | The identification of crocetane in Australian crude oils 显示文摘 | Barber G J Griee K Bastow T P Alexander R Kagi R I | 2001 | Org Geochem2001，32，7： | 1 |
| 15 | Antigenic and biological characterization of avian paramyxovirus type 1 isolatesfrom pigeon- an international collaboration study显示文摘 | Alexander D J Russdl P H Parsons G | 1985 | Avian Pathol1985，14，： | 1 |
| 16 | Variation of Steel Loss and Its Effect on the Ultimate Flexural Ca- pacity of RC Beams Corroded and Repaired under Load 显示文摘 | Malumbela G Alexander M Moyo P | 2010 | Construction and Building Materials2010，24，6： | 1 |
| 17 | Controlling the focus of spatial attention during visual search: effects of advanced aging and Alzheimer's disease 显示文摘 | Greenwood P Parasuraman R Alexander G | 1997 | Neuropsychology1997，11，1： | 1 |
| 18 | Deep venous thrombosis and pulmonary embolism: diagnosis, prophylaxis, and treatment 显示文摘 | Alexander P Giangola G | 1999 | Ann Vase Surg1999，，： | 1 |
| 19 | Nonextraction orthodontic therapy:posttreatment dental and skeletal stability 显示文摘 | GLENN G SINCLAIR P M ALEXANDER R G | 1987 | Am J orthod dentofacial orthop1987，92，： | 1 |
| 20 | Longitudinal Strains and Stiffness of RC Beams under Load as Meas ures of Corrosion Levels 显示文摘 | Malumbela G Moyo P Alexander M | 2012 | Engineering Structures2012，35，21： | 1 |
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