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| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | Intentional ingestions of foreign objects among prisoners: A review显示文摘The intentional ingestion of foreign objects(IIFO) is described more commonly in prison populations than in the general population, with an estimated annual incidence of 1 in 1900 inmates in our state correctional facilities. Incidents often involve ingestion of small metal objects(e.g., paperclips, razor blades) or other commonly available items like pens or eating utensils. Despite ingestion of relatively sharp objects, most episodes can be clinically managed with either observation or endoscopy. Surgery should be reserved for those with signs or symptoms of gastrointestinal perforation or obstruction. For those with a history of IIFO, efforts should focus on prevention of recurrenceas subsequent episodes are associated with higher morbidity, significant healthcare and security costs. The pattern of IIFO is often repetitive, with escalation both in frequency of ingestions and in number of items ingested. Little is known about successful prevention strategies, but efforts to monitor patients and provide psychiatric care are potential best-practice strategies. This article aims to provide state-of-the art review on the topic, followed by a set of basic recommendations. | David C Evans Thomas R Wojda Christian D Jones Andrew J Otey Stanislaw P Stawicki | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，3： | 10 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | 农业生物技术的安全性评价显示文摘转基因作物自1995年开始引入种植,以满足日益增长的粮食和饲料需求。转基因作物用于人类食物和动物饲料需要进行全面的安全性评价,首先从DNA水平考虑,包括插入宿主基因组的是什么DNA,插入的位置和稳定性如何?其次,考虑DNA编码蛋白的安全性及其对作物的潜在效应,确保转入的新蛋白从毒性、致敏性和环境各方面的评价都是安全的,此外,用于食品或动物饲料加工的谷物需要评价其营养成分,必要时还要确定其非预期效应。为给转基因作物的安全性评价提供依据,需要对转基因作物与非转基因对照物进行成分等实质同性分析,质谱及基于抗体的新技术能够对包括内源性致敏原在内的作物成分进行更精确的分析。监管指南文件中提出了许多分析方法及其用途,有一些是全球公认的文件(如食品法典委员会提出的文件)。有些国家的监管机构推荐在某些情况下使用动物模型,但是在转基因作物的安全性评价中,动物模型的使用没有依据。试验方法的质量控制和标准化可以通过采用良好实验室规范来达成,是高质量数据的保证。监管机构对转基因作物的安全性测试方法的要求越来越多,根据目前的评价结果,已经登记的转基因作物与非转基因对照物同等安全。 | Scott McClain Wendelyn Jones 贺晓云 Gregory Ladics Andrew Bartholomaeus Alan Raybould Petra Lutter 徐海滨 王雪 | 2015 | 中华预防医学杂志2015，49，1： | 3 |
| 5 | Suppression of tumour-specific CD4+ T cells by regulatory T cells is associated with progression of human colorectal cancer显示文摘 | Gareth Betts Emma Jones Syed Junaid Tariq El-Shanawany Martin Scurr Paul Mizen Mayur Kumar Sion Jones Brian Rees Geraint Williams Awen Gallimore Andrew Godkin | 2012 | Gut2012，，8： | 3 |
| 6 | Towards Physarum Robots: Computing and Manipulating on Water Surface显示文摘Plasmodium of Physarum polycephalum is an ideal biological substrate for implementing concurrent and parallel com- putation, including combinatorial geometry and optimization on graphs. The scoping experiments on Physarum computing in conditions of minimal friction, on the water surface were performed. The laboratory and computer experimental results show that plasmodium of Physarum is capable of computing a basic spanning tree and manipulating of light-weight objects. We speculate that our results pave the pathways towards the design and implementation of amorphous biological robots. | Andrew Adamatzky Jeff Jones | 2008 | Journal of Bionic Engineering2008，5，4： | 3 |
| 7 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 8 | Comparative transcriptomics of Central Asian Vitis vinifera accessions reveals distinct defense strategies against powdery mildew显示文摘Grape powdery mildew(PM),caused by the biotrophic ascomycete Erysiphe necator,is a devastating fungal disease that affects most Vitis vinifera cultivars.We have previously identified a panel of V.vinifera accessions from Central Asia with partial resistance to PM that possess a Ren1-like local haplotype.In this study,we show that in addition to the typical Ren1-associated late post-penetration resistance,these accessions display a range of different levels of disease development suggesting that alternative alleles or additional genes contribute to determining the outcome of the interaction with the pathogen.To identify potential Ren1-dependent transcriptional responses and functions associated with the different levels of resistance,we sequenced and analyzed the transcriptomes of these Central Asian accessions at two time points of PM infection.Transcriptomes were compared to identify constitutive differences and PM-inducible responses that may underlie their disease resistant phenotype.Responses to E.necator in all resistant accessions were characterized by an early up-regulation of 13 genes,most encoding putative defense functions,and a late down-regulation of 32 genes,enriched in transcriptional regulators and protein kinases.Potential Ren1-dependent responses included a hotspot of co-regulated genes on chromosome 18.We also identified 81 genes whose expression levels and dynamics correlated with the phenotypic differences between the most resistant accessions‘Karadzhandahal’,DVIT3351.27,and O34-16 and the other genotypes.This study provides a first exploration of the functions associated with varying levels of partial resistance to PM in V.vinifera accessions that can be exploited as sources of genetic resistance in grape breeding programs. | Katherine C H Amrine Barbara Blanco-Ulate Summaira Riaz Dániel Pap Laura Jones Rosa Figueroa-Balderas M Andrew Walker Dario Cantu | 2015 | Horticulture Research2015，2，1： | 3 |
| 9 | Mutational Processes Molding the Genomes of 21 Breast Cancers显示文摘 | Serena Nik-Zainal Ludmil B. Alexandrov David C. Wedge Peter Van Loo Christopher D. Greenman Keiran Raine David Jones Jonathan Hinton John Marshall Lucy A. Stebbings Andrew Menzies Sancha Martin Kenric Leung Lina Chen Catherine Leroy Manasa Ramakrishna Ric | 2012 | Cell2012，，5： | 2 |
| 10 | Nonalcoholic fatty liver disease and serum lipoproteins: The Multi-Ethnic Study of Atherosclerosis显示文摘 | Andrew Paul DeFilippis Michael J. Blaha Seth S. Martin Robert M. Reed Steven R. Jones Khurram Nasir Roger S. Blumenthal Matthew J. Budoff | 2013 | Atherosclerosis2013，，： | 2 |
| 11 | Sounds Synthesis with Slime Mould of Physarum Polycephalum显示文摘 | Eduardo R. Miranda Andrew Adamatzky Jeff Jones | 2011 | Journal of Bionic Engineering2011，8，2： | 2 |
| 12 | Naming and outline of Dothideomycetes-2014 including proposals for the protection or suppression of generic names显示文摘Article 59.1,of the International Code of Nomenclature for Algae,Fungi,and Plants(ICN;Melbourne Code),which addresses the nomenclature of pleomorphic fungi,became effective from 30 July 2011.Since that date,each fungal species can have one nomenclaturally correct name in a particular classification.All other previously used names for this species will be considered as synonyms.The older generic epithet takes priority over the younger name.Any widely used younger names proposed for use,must comply with Art.57.2 and their usage should be approved by the Nomenclature Committee for Fungi(NCF).In this paper,we list all genera currently accepted by us in Dothideomycetes(belonging to 23 orders and 110 families),including pleomorphic and nonpleomorphic genera.In the case of pleomorphic genera,we follow the rulings of the current ICN and propose single generic names for future usage.The taxonomic placements of 1261 genera are listed as an outline.Protected names and suppressed names for 34 pleomorphic genera are listed separately.Notes and justifications are provided for possible proposed names after the list of genera.Notes are also provided on recent advances in our understanding of asexual and sexual morph linkages in Dothideomycetes.A phylogenetic tree based on four gene analyses supported 23 orders and 75 families,while 35 families still lack molecular data. | Nalin N.Wijayawardene Pedro W.Crous Paul M.Kirk David L.Hawksworth Saranyaphat Boonmee Uwe Braun Dong-Qin Dai Melvina J.D’souza Paul Diederich Asha Dissanayake Mingkhuan Doilom Singang Hongsanan E.B.Gareth Jones Johannes Z.Groenewald Ruvishika Jayawardena James D.Lawrey Jian-Kui Liu Robert Lücking Hugo Madrid Dimuthu S.Manamgoda Lucia Muggia Matthew P.Nelsen Rungtiwa Phookamsak Satinee Suetrong Kazuaki Tanaka Kasun M.Thambugala Dhanushka N.Wanasinghe Saowanee Wikee Ying Zhang Andre Aptroot H.A.Ariyawansa Ali H.Bahkali D.Jayarama Bhat Cécile Gueidan Putarak Chomnunti G.Sybren De Hoog Kerry Knudsen Wen-Jing Li Eric H.C.McKenzie Andrew N.Miller Alan J.L.Phillips Marcin Piatek Huzefa A.Raja Roger S.Shivas Bernad Slippers Joanne E.Taylor Qing Tian Yong Wang Joyce H.C.Woudenberg Lei Cai Walter M.Jaklitsch Kevin D.Hyde | 2014 | Fungal Diversity2014，，6： | 2 |
| 13 | Mucoadhesive polymeric platforms for controlled drug delivery显示文摘 | Andrews GP Laverty TP Jones DS | 2009 | Eur J Pharm Biopharm2009，71，3： | 1 |
| 14 | Mucoadhesive polymeric platforms for controlled drug detivery 显示文摘 | Andrews GP Laverty TP Jones DS | 2009 | Eur J Pharm Biopharm2009，71，： | 1 |
| 15 | Synthesis and characterization of multiresponsive core-shell microgels显示文摘 | Clinton D Jones Andrew Lyon L | 2000 | Macromolecules2000，33，22： | 1 |
| 16 | Distributions of Mercury and Phosphorous in Everglades Soils From Water Conservation Area 3A, Florida, U.S.A.显示文摘 | Cleone Arfstrom Andrew W. Macfarlane Ronald D. Jones | 2000 | Water Air and Soil Pollution (-)2000，，1： | 1 |
| 17 | The importance of the follicular phase to success and failure in in vitro fertilization显示文摘 | Jones HW Jr Acosta A Andrews MC | 1983 | Fertil Stefil1983，40，： | 1 |
| 18 | Optimal sedation for gastroin--testinal endoscopy: review and recommenda tions显示文摘 | Thomson A Andrew G Jones DB | 2010 | J Gastmenterol Hepatol2010，，25： | 1 |
| 19 | Biological Method for Protection of 6-position of Sucrose and Its Use in Synthesis of Disaccharide High-intensity Sweetener显示文摘 | JONES Joan D HACKING Andrew J CHEETHAM Peter S J | 1992 | Biotechnol Bioeng1992，39，2： | 1 |
| 20 | Adding insult to injury: the prognostic value of early secondary insults for survival after traumatic brain injury显示文摘 | Signorini DF Andrews PJ Jones PA | 1999 | J Neurel Neuresurg Psychiatry1999，66，1： | 1 |
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