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| 1 | Selective sphincteroplasty of the papilla in cases at risk due to atypical anatomy显示文摘AIM: To analyze the indications, effi cacy and safety of sphincteroplasty in our centre. METHODS: A retrospective study of sphincteroplasty in 53 cases of papilla at high risk was performed in 2004-2006. The procedure consisted of duodenoscopy with Olympus TJF 145 Videoduodenoscope, approach to the biliary tract using a catheter with a guidewire, and dilatation of the papilla with a dilatation balloon catheter using a syringe with a manometer for control of the fi lling pressure. RESULTS: The indications included intradiverticular papilla in 26 patients (49/), stenosis of a previous sphincterotomy in 19 patients (35.8/), small size of the papilla in 4 patients (7.5/), Billroth Ⅱ gastrectomy in 3 patients (5.6/), and coagulopathy in one patient (1.9/). The efficacy was 97.8/, with all the calculi extracted from the common bile duct in 84.4/ of the patients, even though 21 of the patients (39.6/) had calculi with a diameter equal to or greater than 10 mm. Seven patients (13.2/) presented complications: haemorrhage in 1 patient (1.9/) and mild pancreatitis in 6 patients (11.3/). The mean hospital stay in case of complications was of 3 ± 0.63 d. CONCLUSION: Sphincteroplasty is highly effective, with a complication rate similar to that of sphincterotomy, furthermore, the complications are of low clinical importance. The use of the 10 mm balloon makes it possible to extract calculi with a diameter of over 15 mm and to extract more than 3 calculi without increasing the rate of complications and reduces the need to resort tolithotripsy or rescue sphincterotomy. | F Mugica G Urdapilleta A Castiella A Berbiela F Alzate E Zapata L Zubiaurre P Lopez JI Arenas | 2007 | World Journal of Gastroenterology2007，13，22： | 5 |
| 2 | Effectiveness of an intervention for reducing social stigma towards mental illness in adolescents显示文摘AIM: To evaluate the effectiveness of an intervention for reducing social stigma towards mental illness in adolescents. The effect of gender and knowledge of someone with mental illness was measured. METHODS: Two hundred and eighty secondary school students were evaluated using the Community Attitudes towards Mental Illness(CAMI) questionnaire. The schools were randomized and some received the intervention and others acted as the control group. The programme consisted of providing information via a documentary film and of contact with healthcare staff in order to reduce the social stigma within the school environment. RESULTS: The intervention was effective in reducing the CAMI authoritarianism and social restrictiveness subscales. The intervention showed significant changes in girls in terms of authoritarianism and social restrictiveness, while boys only showed significant changes in authoritarianism. Following the intervention, a significant reduction was found in authoritarianism and social restrictiveness in those who knew someone with mental illness, and only in authoritarianism in those who did not know anyone with mental illness. CONCLUSION: The intervention was effective to reduce social stigma towards people with mental illness, especially in the area of authoritarianism. Some differences were found depending on gender and whether or not the subjects knew someone with mental illness. | Regina Vila-Badia Francisco Martínez-Zambrano Otilia Arenas Emma Casas-Anguera Esther García-Morales Raúl Villellas José Ramón Martín María Belén Pérez-Franco Tamara Valduciel Diana Casellas Mar García-Franco Jose Miguel Joaquim Balsera Gemma Pascual Eugènia Julia Susana Ochoa | 2016 | World Journal of Psychiatry2016，6，2： | 4 |
| 3 | Translational pancreatic cancer research:a comparative study on patient-derived xenograft models显示文摘AIM To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude mice.METHODS This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were obtained surgically from patients with a pathological diagnosis of pancreatic adenocarcinoma. Tumour samples from pancreatic cancer patients were transplanted into nude mice in three different locations(intraperitoneal, subcutaneous and pancreatic). Histological analysis(haematoxylin-eosin and Masson's trichrome staining) and immunohistochemical assessment of apoptosis(TUNEL), proliferation(Ki-67), angiogenesis(CD31) and fibrogenesis(α-SMA) were performed. When a tumour xenograft reached the target size, it was reimplanted in a new nude mouse. Three sequential tumour xenograft generations were generated(F1, F2 and F3).RESULTS The overall tumour engraftment rate was 61.1%. The subcutaneous model was most effective in terms of tissue growth(69.9%), followed by intraperitoneal(57.6%) and pancreatic(55%) models. Tumour development was faster in the subcutaneous model(17.7 ± 2.6 wk) compared with the pancreatic(23.1 ± 2.3 wk) and intraperitoneal(25.0 ± 2.7 wk) models(P = 0.064). There was a progressive increase in the tumour engraftment rate over successive generations for all three models(F1 28.1% vs F2 71.4% vs F3 80.9%, P < 0.001). There were no significant differences in tumour xenograft differentiation and cell proliferation between human samples and the three experimental models among the sequential generations of tumour xenografts. However, a progressive decrease in fibrosis, fibrogenesis, tumour vascularisation and apoptosis was observed in the three experimental models compared with the human samples. All three pancreatic patient-derived xenograft models presented similar histological and immunohistochemical characteristics.CONCLUSION In our experience, the faster development andgreatest number of viable xenografts could make the subcutaneous model the best option for experimentation in pancreatic cancer. | Mercedes Rubio-Manzanares Dorado Luis Miguel Marín Gómez Daniel Aparicio Sánchez Sheila Pereira Arenas Juan Manuel Praena-Fernández Juan Jose Borrero Martín Francisco Farfán López Miguel ángel Gómez Bravo Jordi Muntané Relat Javier Padillo Ruiz | 2018 | World Journal of Gastroenterology2018，24，7： | 2 |
| 4 | Multi-Centre European Experience with Intragastric Balloon in Overweight Populations: 13 Years of Experience显示文摘 | Alfredo Genco Gontrand López-Nava Christian Wahlen Roberta Maselli Massimiliano Cipriano Maria Mara Arenas Sanchez Chantal Jacobs Michele Lorenzo | 2013 | Obesity Surgery2013，，4： | 2 |
| 5 | A randomized trial of yogurt for prevention of antibioticassociated diarrheal 显示文摘 | Arena VC Thomas L | 2003 | Dig Dis Sci2003，48，10： | 1 |
| 6 | Community analysis in social networks显示文摘 | ARENAS A DANON L DIAZ-GUILERA A | 2004 | European Physical Journal B2004，38，2： | 1 |
| 7 | Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-alpha) and essential hypertension 显示文摘 | Bautista L E Vera L M Arenas I A | 2005 | J Hum Hypertens2005，19，2： | 1 |
| 8 | Independent association between inflammatory markers (C- reactive protein, interleukin-6, and TNFα) and essential hypertension显示文摘 | BAUTISTA L E VERA L M ARENAS I A | 2005 | J Hum Hypertens2005，19，1： | 1 |
| 9 | Scalar aggregation in inconsistent databases显示文摘 | Arenas M Bertossi L Chomicki J | | 0，，03： | 1 |
| 10 | Impact of exercise training on adverse event risk and quality of life in patients with heart failure 显示文摘 | CAHALIN L P ARENA R | 2012 | Phys Ther2012，92，11： | 1 |
| 11 | Normal Form for XML Documents显示文摘 | Arenas M Libkin L | 2004 | ACM Transactions on Database Systems2004，29，1： | 1 |
| 12 | Coping and distress a mong women under treatment for early stage 'breast cancer : compa ring African Americans, Hispanics and non Hispanics whites显示文摘 | Culver J L Arena P L Antoni M H | 2002 | Psychooncology2002，11，6： | 1 |
| 13 | The minute ventilation/ carbon dioxide production slope is prognostically superior to the oxygen uptake efficiency slope显示文摘 | Arena R Myers 1 Hsu L | 2007 | J Card Fail2007，13，6： | 1 |
| 14 | A comparison of Class Ⅱ treatment changes noted with the light wire,edgewise,and Frankel appliances显示文摘 | Gianelly AA Arena SA Bernstein L | 1984 | Am J Orthod1984，86，4： | 1 |
| 15 | CTX-M-type be- ta-lactamases: A successful story of antibiotic resistance 显示文摘 | D'Andrea M M Arena F Pallecchi L | 2013 | In- tern J Med Microbiol2013，303，67： | 1 |
| 16 | Use of FGD gypsum in fire resistant panels显示文摘 | Leiva C García Arenas C Vilches L F | | 0，，06： | 1 |
| 17 | A normal form for XML documents 显示文摘 | M Arenas L Libkin | 2004 | ACM Transactions on Datab-ase Systems2004，29，1： | 1 |
| 18 | A CNN Algorithm for Real Time Analysis of DNA Microarrays显示文摘 | Arena P Fortuna L Occhipinti L | 2002 | IEEE Trans on Circuits and Systems I:Fundamental Theory and Applications2002，49，3： | 1 |
| 19 | Cerebrospinal fluid frainage to prevent paraplegia during thoracic and thoracoabdominal aortic aneurysm surgery: A systematic review and meta-analysis 显示文摘 | Cina CS Abouzahr L Arena GO | 2004 | J Vasc Surg2004，40，1： | 1 |
| 20 | Use of FGD gypsum in fire resistant panels显示文摘 | Leiva C Gareia Arenas C Vilches L F | 2010 | Waste Manage2010，30，6： | 1 |
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