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| 1 | Starting glargine in insulin-nave type 2 diabetic patients based on body mass index is safe显示文摘AIM:To evaluate the safety of four insulin titration algorithms in a homogeneous population of insulin-na ve type 2 diabetic patients.METHODS:We conducted a 24-wk,open,single-center study with 92 insulin-na ve type 2 diabetes patients who failed treatment with one or two oral drugs.The patients were randomized to one of the four following algorithms:LANMET(n=26)and LANMET PLUS(n=22)algorithms,whose patients received a fixed initial insulin dose of 10 U,and DeGold(n=23)and DeGold PLUS(n=21)algorithms,whose patients’initial insulin dose was based on their body mass index(BMI).In addition,patients in the PLUS groups had their insulin titrated twice a week from 2 to 8 U.In the other two groups,the titration was also performed also twice a week,but in a fixed increments of 2 U.The target fasting glucose levels for both groups was 100 mg/dL.RESULTS:There was no significant difference in efficacy parameters.There was no significant difference when comparing moderate hypoglycemia events in algorithms starting with a 10 U fixed dose and algorithms based on BMI.However,there was a significant increase in moderate hypoglycemia events among the PLUS treated patients when the LANMET and DeGold algorithms were compared with the 2 fast-titration PLUS algorithms.We observed 12 hypoglycemia events in the first group,which corresponded to 0.94 events/patient per year,and we observed 42 events in the second group,which corresponded to 2.81 events/patient per year(P<0.037).No further significant differences were observed when other comparisons between the algorithms were carried out.CONCLUSION:Starting insulin glargine based on BMI is safe,but fast titration algorithms increase the risk of moderate hypoglycemia. | Denise R Franco Juliana Baptista Fatima RM Abreu Risoneide B Batista Freddy G Eliaschewitz | 2014 | World Journal of Diabetes2014，5，1： | 2 |
| 2 | The effects of SOM230 on cell proliferation and adrenocorticotropin se- cretion in human corticotroph pituitary adenomas 显示文摘 | Batista DL Zhang X Gejman R | 2006 | J Clin Endocrinol Metab2006，91，11： | 1 |
| 3 | Effects of taurine supplementation upon food intake and central insulin signaling in malnourished mice fed on a high-fat diet显示文摘 | Camargo R L Batista T M Ribeiro R A | 2013 | Advances in Experi- mental Medicine and Biology2013，4776，： | 1 |
| 4 | High efficiency steam reforming of ethanol by cobalt-based catalysts显示文摘 | Batista M S Santos R K S M Assaf E M | 2004 | J Power Sources2004，134，1： | 1 |
| 5 | A Study of the Behavior of Several Methods for Balancing Machine Learning TrainingData显示文摘 | Batista G E A Prati R C Monard M C | 2004 | ACM SIGKDD Explorations Newsletter2004，6，1： | 1 |
| 6 | Photocatalyst TiO2-Co: the effect of doping depth profile on methylene blue degradation显示文摘 | CARVALHO H P BATISTA A L BERTHOLDO R | 2010 | Journal of Materials Science2010，45，20： | 1 |
| 7 | Anti-inflammatory effect of physical training in heartfailure:role of TNF-alpha and IL-10显示文摘 | BATISTA M L Jr LOPES R D SEELAENDER M C | 2010 | Cardiol2010，95，2： | 1 |
| 8 | The effects of SOM230 on cell proliferation and adrenocorticotropin secretion in human corticotroph pituitary adenomas显示文摘 | Batista LD Zhang X Gejman R | | 0，，11： | 1 |
| 9 | Risk factors for catheter-related bloodstream infection:a prospective multicenter study in Brazilian intensive care units显示文摘 | Bicudo D Batista R Furtado GH | | 0，，04： | 1 |
| 10 | Risk factors for catheter- related bloodstream infection: a prospective multicenter study in Brazilian intensive care units 显示文摘 | Bicudo D Batista R Furtado GH | 2011 | Braz J Infect Dis2011，15，4： | 1 |
| 11 | Partial left ventriculectomy-the Batista procedure显示文摘 | | 1999 | Eur J Cardiothorac Surg1999，15，1： | 1 |
| 12 | Characterization of the activity and stability of supported cobalt catalysts for the steam reforming of ethanol显示文摘 | Batista M S Santos R K S M Assaf E M | 2003 | J Power Sources2003，24，1： | 1 |
| 13 | The effects of SOM230 on cell proliferation and adrenocorticotropin secretion in human corticotroph pituitary adenomas 显示文摘 | Batista DL Zhang X Gejman R | 2006 | J Clin Endocrinol Metab2006，91，11： | 1 |
| 14 | Partial left Ventriculectomy-the Batista procedure显示文摘 | Batista R | 1999 | Eur J Cardiothorac Surg1999，，： | 1 |
| 15 | Lidar observations of atmospheric sodium at an equatorial location显示文摘 | Clemesha B R Simonich D M Batista P P | 1998 | Journal of Atmospheric and Solar-Terrestrial Physics1998，60，： | 1 |
| 16 | Densification behavior, microstructure evolution, and wear performance ofselective laser melting processed commercially pure titanium 显示文摘 | GU D D HAGEDOMRN Y C MEINERS W MENG G B BATISTA R J S WISSENBACH K POPRAWE R | 2012 | Acta Materialia2012，60，9： | 1 |
| 17 | Taurine supplementation restores glucose and carbachol-induced insulin secretion in islets from low-protein diet rats:involvement of Ach-M3R,Synt 1 and SNAP-25 proteins显示文摘 | BATISTA T M RIBEIRO R A AMARAL A G | 2012 | Journal of Nutritional Biochemistry2012，23，： | 1 |
| 18 | Isolation and characterization of biosurfactant/bioemulsifier-producing bacteria from petroleum contaminated sites显示文摘 | Batista S B Mounteer A H Amorim F R | 2006 | Bioresource Technology2006，97，： | 1 |
| 19 | Risk factors {or cath- eter-related bloodstream infection: a prospective multieenter study in Brazilian intensive care units显示文摘 | Bicudo D Batista R Furtado GH | 2011 | Brazilian Journal of Infectious Diseases2011，15，4： | 1 |
| 20 | Endurance training modulates lymphocyte function in rats with post-MI CHF 显示文摘 | BATISTA M L J R SANTOS R V LOPES R D | 2008 | Med Sci Sports Exerc2008，40，3： | 1 |
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