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	题名	作者	年代	出处	被引量
1	Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci.	Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh	2010	World Journal of Gastroenterology2010，16，2：	2
2	Virtual Campeche: a Web Based Virtual Three-Dimensional Tour 显示文摘	Zara J Benes B	2004	Computer Science2004，，19：	1
3	The MIQE guide- lines: Minimum information for publication of quantita- tive real-time PCR experiments显示文摘	Bustin S A Benes V Garson J A	2009	Clin Chem2009，55，4：	1
4	The eftects tf goal-directed fluid therapy based on dynami' parameters on posl-surgical outdome: a meta-analysis of randomized controlled trials显示文摘	Benes J Giglio M Brienza N	2014	Crit Care2014，18，5：	1
5	Model investigation of push-out test used for quantitative evaluation of dental implant osseointegration 显示文摘	Perenyi J Bene L Radnai M	2002	Fogorv Sz2002，95，3：	1
6	Dynamics of gene expression revealed by comparison of serial analysis of gene expression transcript profiles from yeast grown on two different carbon sources 显示文摘	Kal A J Van Zonneveld A J Benes V	1999	Mol Biol Cell1999，10，6：	1
7	Two-bond ^19F-^15N spin-spin coupling constants (^2hJF-N) across F-H……N hydrogen bonds显示文摘	Del Bene J E Perera S A Rodney J	2003	J Phys Chem A2003，107，：	1
8	Quantized phonon spectrum of single-wall carbon nanotubes显示文摘	Hone J Batlogg B Benes Z	2000	Science2000，289，5485：	1
9	Intraoperative fluid optimization using stroke volume variation in high risk surgical patients : results of prospective randomized study 显示文摘	Benes J Chytra I Ahmann P	2010	Crit Care2010，14，3：	1
10	The restructuring of muscarinic receptor subtype gene transcripts in c-fos knock-out mice 显示文摘	Benes J Mravec B K vetnansky R	2013	Brain Res Bull2013，94，：	1
11	The MIQE guidelines: minimum information for publication of quantitative real-tlme PCR experiments 显示文摘	Bustin S A Benes V Garson J A	2009	Clin Chem2009，55，4：	1
12	The MIQE guidelines:minimum information for publication of quantitative real-time PCR experiments显示文摘	BUSTIN S A BENES V GARSON J A	2009	Clin Chem2009，55，4：	1
13	Intraoperative fluid optimization using stroke volume variation in high risk surgical patients:results of prospective randomized study显示文摘	Benes J Chytra I Altmann P	2010	Crit Care2010，14，3：	1
14	Elevated Levels of Anti- Helicobacter pylori Antibodies in Henoch–Sch?nlein Purpura显示文摘	János Novák Zoltán Szekanecz Judit Sebesi Alajos Takáts Pál Demeter László Bene Sándor Sipka Zoltán Csiki	2003	Autoimmunity2003，，5：	1
15	The MIQE guidelines:minimum information for publication of quantitative real-time PCR experiments显示文摘	BUSTIN S A BENES V GARSON J A	2009	Clin Chem2009，55，4：	1
16	Neutral search technique for short-term pump schedule optimization显示文摘	BENE J G SELEK I HS C	2010	Water Resour Plng Mgmt2010，136，1：	1
17	The MIQE guidelines:min imum information for publication of quantitative real-time PCR experiments显示文摘	Bustin S A Benes V Garson J A	2009	Clin Chem2009，55，4：	1
18	Point mutation of bacterial artificial chromosomes by ET recombination 显示文摘	Muyrers J P P Zhang Y Benes V	2000	EMBO Rep2000，1，3：	1
19	Intraoperative fluid optimizationusing stroke volume variation in high risk surgical patients:results ofprospective randomized study显示文摘	Benes J Chytra I Altmann P	2010	Crit Care2010，4，3：	1
20	Im- portance of acoustic shielding in sonochemistry显示文摘	IERSEL M M V BENES N E KEURENTJES J T F	2008	Ultra- sonics Sonochemistry2008，15，4：	1

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