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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Causes of isehemie stroke in young adults, and evolution of the etiological diagnosis over the long term显示文摘 | Varona J F Guerra J M Bermejo F | 2007 | Eur Neurol2007，57，4： | 1 |
| 3 | Active Antifungal Substances from Natural Sources显示文摘 | ABAD M J ANSUATEGUI M BERMEJO P | 2007 | Arkivoc2007，，7： | 1 |
| 4 | Analysis of bioactive compounds in seven citrus cultivars显示文摘 | BERMEJO A LLOSA M J CANO A | | 0，，01： | 1 |
| 5 | Update on medical therapy for obscure gastrointestinal hemorrhage显示文摘 | Molina Infante J Pérez Gallardo B Fernández Bermejo M | 2007 | Revista Espaola de Enfermedades Digestivas2007，99，8： | 1 |
| 6 | Flow-injection Stopped-flow Spectrofluorimetric Kinetic Determination of Paracetamol Based on Its Oxidation Reaction by Hexaeyanoferrate( Ⅲ )显示文摘 | Pulgarin J A M Bermejo L F G | 1996 | Anal Chim Acta1996，333，12： | 1 |
| 7 | Acetogenins from annonaceae:recent progress in isolation,synthesis and mechanisms of action显示文摘 | Bermejo A Figadère B Zafra-Polo M C | 2005 | Nat Prod Rep2005，22，： | 1 |
| 8 | Exposure to Volatile Organic Compounds(VOC) in Public Buses of Pamplona,Northern Span显示文摘 | Parra M A Elustondo D Bermejo R | 2008 | Science of The TotalEnvironment2008，，404： | 1 |
| 9 | Experi- mental study of the operational parameters of a tran- spiring wall reactor for supercritical water oxidation 显示文摘 | Bermejo M D Fdez-Polanco F Cocero M J | 2006 | The Journal of Supercritical Fluids2006，39，5： | 1 |
| 10 | Recovery of pure B-phycoerythrin from the microalga Porphyridium cruentum 显示文摘 | BERMEJO R R ALVAREZ-PEZ J M ACII~N F F G | 2002 | J Biotechnol2002，93，1： | 1 |
| 11 | Influence of porosity on the apparent inter|aminar shear strength of pitch based unidirectional C-C Composites 显示文摘 | CASAL E GRANDA M BERMEJO J | 2001 | Carbon2001，39，： | 1 |
| 12 | Effect of the transpiring wall on the behavior of a supercritical water oxidation reactor: Modeling and experimental results显示文摘 | Bermejo M D Fdez-Polanco F Cocero M J | 2006 | Ind Eng Chem Res2006，45，10： | 1 |
| 13 | Flow-injection stopped-flow spectrofluorimetric kinetic determination of paracetamol based on its oxidation reaction by hexacyanoferrate(IID 显示文摘 | PULGARIN J A M BERMEJO L F G | 1996 | Anal Chim Acta1996，333，12： | 1 |
| 14 | A GRASP algorithm for fast hybrid (filterwrapper) feature subset selection in highdimensional datasets显示文摘 | BERMEJO P GMEZ J A PUERTA J M | 2011 | Pattern Recognition Letters2011，32，5： | 1 |
| 15 | Antiviral activity of seven iridoids, three saikosaponins and one phenylpropanoid glycoside extracted from Bupleurum rigidum and Scrophularia scorodonia显示文摘 | Bermejo P Abad M J Diaz AM | 2002 | Planta Med2002，68，2： | 1 |
| 16 | Bacillary angiomatosis with atypical clinical presen- tation in an immunocompetent patient 显示文摘 | Bernabeu-Wittet J Luque R Corbi R Mantrana- Bermejo M | 2010 | Indian j Dermatol Venereol Leprol2010，76，6： | 1 |
| 17 | Job Stressors and Satisfaction in the Nursing Staff of a Critical Unit显示文摘 | Simón M G Blesa A M Bermejo P C | 2005 | Enferm Intensiva2005，16，1： | 1 |
| 18 | Supereritical water oxidation of foods with high ammonia concentrations:Pilot plant experimental results and modeling显示文摘 | Bermejo M D Cantero F CoceroM J | | 0，，03： | 1 |
| 19 | Long-term oncological outcomes after laparoscopic radical prostatectomy 显示文摘 | Hruza M Bermejo JL Flinspach B | 2013 | BJU Int2013，111，： | 1 |
| 20 | Sorafenib in combination with capecitabine: an oral regimen for patients with HER2-negative locally advanced or metastatic breast cancer 显示文摘 | Baselga J Segalla JG Roch6 H Del Giglio A Pinczowski H Ciruelos EM Filho SC G6mez P Van Eyll B Bermejo B Llombart A Garicochea B Durdn Md Hoff PM Espi6 M de Moraes AA Ribeiro RA Mathias C Gil Gil M Ojeda B Morales J Kwon Ro S Li S Costa F | 2012 | J Clin Oncol2012，30，13： | 1 |
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