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| 1 | 中国妇女妊娠前后单纯服用叶酸对神经管畸形的预防效果显示文摘目的 评价妇女在妊娠前后服用单纯 40 0 μg叶酸增补剂对胎 /婴儿神经管畸形 (NTDs)的预防效果。方法 1993~ 1995年在中国北方的NTDs高发地区和南方的NTDs低发地区妇女增补叶酸的推广项目中 ,共募集从孕前或孕后任何时间开始服药的妇女 130 142名 ,未服药的妇女 1176 89名 ;设计的服药方法从婚检时开始到孕满 3个月为止 ,每天服用单纯叶酸片 40 0 μg ;最后对妇女的分娩结局进行监测并进行预防效果的对比评价研究。结果 服药组妇女生育的胎婴儿中共发现 10 2例NTDs ,对照组胎婴儿中共发现 173例NTDs。末次月经前募集的未服药妇女在孕 2 0周以后分娩的胎婴中NTDs发生率 ,北方为 4 8‰ (16 / 3 318) ,南方为 1 0‰ (2 8/ 2 82 6 5 ) ,而妊娠前后服药妇女组则分别为1 0‰ (13/ 13 0 12 )和 0 6‰ (34/ 5 86 38)。与末次月经前募集的未服药妇女组相比 ,北方服药妇女NTDs发生率明显降低 ,其中依从性大于 80 %的服药组妇女预防率达 85 % (95 %CI为 6 2 %~ 94% ) ,南方地区服叶酸的预防率为 41% (95 %CI为 3 %~ 6 4% )。结论 妇女在妊娠前后每天服用单纯叶酸 40 0 | 李竹 RobertJ Berry 李松 J David Erickson 王红 Cynthia A Moore 赵平 Joseph Mulinare 洪世欣 Lee-Yang C Wong 呼和牧人 Jacqueline Gindler 郝玲 Adolfo Correa 朱慧萍 Elaine Gunter | 2000 | 中华医学杂志2000，80，7： | 185 |
| 2 | Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review显示文摘AIM To critically assess the available literature regarding the efficacy of thioguanine treatment in inflammatory bowel disease(IBD) patients, irrespective of the(hepato-) toxicity profile.METHODS A systematic literature search of the MEDLINE database using Pub Med was performed using the keywords 'thioguanine', '6-TG', 'thioguanine', 'inflammatory bowel disease', 'IBD', 'Crohn's disease', 'Ulcerative colitis' and 'effectiveness' in order to identify relevant articles published in English starting from 2000. Reference lists of the included articles were crosschecked for missing articles. Reviewed manuscripts concerning the effectiveness of thioguanine treatment in IBD were reviewed by the authors and the data were extracted. Data were subsequently analyzed with descriptive statistics. Due to the lack of standardized outcomes, a formal meta-analysis was not performed.RESULTS A total of 11 applicable studies were found that involved the effectiveness of thioguanine therapy in IBD. Eight studies were conducted in a prospectivemanner, in the remaining three studies, data was collected retrospectively. In total, 353 IBD-patients(225 patients with Crohn's disease, 119 with ulcerative colitis and nine with unclassified IBD) with prior azathioprine/mercaptopurine resistance and/or intolerance(n = 321) or de novo thioguanine administration(n = 32) were included for analysis, of which 228(65%) had clinical improvement on thioguanine therapy, based on standard IBD questionnaires, biochemical parameters or global physician assessments. Short-term results were based on 268 treatment years(median follow-up 9 mo, range 3-22 mo) with a median daily dose of 20 mg(range 10-80 mg). Discontinuation, mostly due to adverse events, was reported in 72 patients(20%). CONCLUSION The efficacy of thioguanine therapy in IBD patients intolerant to conventional thiopurine therapy is observed in 65%, with short term adverse events in 20% of patients. | Berrie Meijer Chris JJ Mulder Godefridus J Peters Adriaan A van Bodegraven Nanne KH de Boer | 2016 | World Journal of Gastroenterology2016，22，40： | 5 |
| 3 | Symposium-Minimally invasive total hip arthroplasty 显示文摘 | Berry Daniel J Berger Richard A Callaghan John J | 2003 | J Bone Joint Surg (Am)2003，85，11： | 2 |
| 4 | Photosynthetic Response and Adaptation to Temperature in Higher Plants显示文摘 | J Berry O Bjorkman | 1980 | Annual Review of Plant Physiology1980，，： | 2 |
| 5 | Photosynthetic Response and Adaptation to Temperature in Higher Plants显示文摘 | J Berry O Bjorkman | 1980 | Annual Review of Plant Physiology1980，，： | 2 |
| 6 | Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve显示文摘 | Berry M Carlile J Hunter A | 1996 | J Neurocytol1996，25，2： | 1 |
| 7 | Legality:Integrating the Lean and Agile Manufacturing Paradigms in the Total Supply Chmn显示文摘 | Mohamed M Berry D | 1999 | Intemational Journal of Production Economics1999，，62： | 1 |
| 8 | Advances in Germanium Ddtector Teehnology显示文摘 | Sangsingkeow Pat Berry KevinD Dumas Edward J | 2003 | Nu- clear Instruments and Methods in Physics Research SectionA: Accelerators Spectrometers Detectors and Associated Equipment2003，505，122： | 1 |
| 9 | Regulatory circuit for responses of nitrogen catabolic gene expression to the GLN3 and DAL80 proteins and nitrogen catabolite repression in Saccharomyces cerevisiae 显示文摘 | Daugherty J R Rai R E1 Berry H M | 1993 | J Bacteriol1993，175，1： | 1 |
| 10 | Effects of graduated compression stockings on blood lactate following an exhaustive bout of exercise显示文摘 | BERRY M J MCMURRAY R G | 1987 | Am J Physiol Med1987，61，： | 1 |
| 11 | Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy cows显示文摘 | Kelly M L Berry D A Dwyer J M | 1998 | J Nutr1998，128，： | 1 |
| 12 | Distributed interference compensation for wireless networks 显示文摘 | HUANG J BERRY R A HONIG M L | 2006 | IEEE Journal on Selected Areas in Communications2006，24，5： | 1 |
| 13 | The influence of speed, grade and mass during simulated off road bicycling 显示文摘 | Koves T R Berry M J Benedetto J J | 2000 | Applied Ergonomics2000，31，： | 1 |
| 14 | A Psychology of Immigration 显示文摘 | BERRY J W | 2001 | Journal of Social Issues2001，57，3： | 1 |
| 15 | Character- ization,dynamics, and ecological impacts of harmful Cochlodini- um polykrikoides blooms on eastern Long Island, NY USA 显示文摘 | GOBLER C J BERRY D L ANDERSON O R | 2008 | Harmful Algae2008，7，： | 1 |
| 16 | Lymphocytic myocarditisafter lung transplantation 显示文摘 | Weinkauf J Walia R Berry GJ | 2005 | J Heart Lung Transplant2005，24，8： | 1 |
| 17 | Plant population and plant date effects on cotton ( Gossypium hirsutum) growth and yield 显示文摘 | O' BERRY N B FAIRCLOTH J C EDMISTEN K L | 2008 | J Cotton Sci2008，12，： | 1 |
| 18 | Attitudes and bar- riels to incident reporting:A collaborative hospital study 显示文摘 | Evans S M Berry J G Smith B J | 2006 | Qual Saf Health Care2006，15，1： | 1 |
| 19 | Distal aortopulmonary septal defect,aortic origin of the right pulmonary artery,intact ventficular septum,patent ductus arteriosus and hypoplasia of the aortic isthmus:a newly recognized syndrome显示文摘 | Berry T E Bharati S Muster A J | | 0，，01： | 1 |
| 20 | Detection and identification of symbiotic bacteria (Photorhabdus and Xenorhabdus) from entomopathogenic nematodes (Heterorhabditis and Steinernema) 显示文摘 | Liu J Berry R E Blouin M | 2001 | Journal of Invertebrate Pathology2001，77，： | 1 |
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