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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsia 显示文摘 | Pineles BL Romero R Montenegro D | 2007 | Am J Obstet Gynecol2007，196，3： | 1 |
| 3 | DNT-like neoplasm of the septum pellucidum:a lesion often misdiagnosed as glioma: report of 10 cases显示文摘 | Baisden BL Brat D J Melhem ER | 2001 | Am J Surg Pathol2001，25，4： | 1 |
| 4 | Neuroendoscopic treatment for colloid cysts of the third ventricle:experience of a decade显示文摘 | Hellwig D Bauer BL Schulte M | 2003 | Neurosurg2003，52，7： | 1 |
| 5 | Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102 显示文摘 | Sennino B Falcon BL McCauley D | 2007 | Cancer Res2007，67，15： | 1 |
| 6 | Evidence for a stereotypic difference in post-transcriptional regulation of placental gene expression in preeclampsia and SGA:An explanation for the two different phenotypes? 显示文摘 | Pineles BL Romero R Montenegro D | 2006 | Am J Obstet Gynecol2006，195，6： | 1 |
| 7 | The removal of plates and screws after Le Fort I osteotomy显示文摘 | Perrott DH Mahan D | 1998 | J Oral Maxillofac Surg1998，56，： | 1 |
| 8 | Birthweight, childhood growth and risk of breast cancer in a British cohort显示文摘 | Stavola BL Hardy R Kuh D | 2000 | Br J Cancer2000，83，7： | 1 |
| 9 | Effects of an intravenous infusion of a potassium-glucose-insulin solution on the electrocardiographic signs of myocardial infarction显示文摘 | Sodi-Pollares D Testelli MR Fishleder BL | 1962 | Am J Cardiol1962，9，： | 1 |
| 10 | Stress and immune responses after surgical treatment for regional breast cancer显示文摘 | Andersen BL Farrar WB Golden-kreutz D | 1998 | J Natl Cancer Inst1998，90，1： | 1 |
| 11 | Numerical investigation of the performance of several static mixers显示文摘 | Rauline D Tanguy P A Le Blévec J M | 1998 | The Canadian Journal of Chemical Engineering1998，76，3： | 1 |
| 12 | 2006 Bethesda International Consensus recommendations on the immunophenotypic analysis of hematolymphoid neoplasia by flow cytometry:optimal reagents and reporting for the flow cytometric diagnosis of hematopoietic neoplasia显示文摘 | Wood BL Arroz M Barnett D | | 0，，01： | 1 |
| 13 | Sudden death, im- paired glucose tolerance, and diabetes in Japanese American Man 显示文摘 | Curb D Rodriguez BL Burchefiel CM el al | 1995 | Circulation1995，91，10： | 1 |
| 14 | Development of a 3D-printed external ventricular drain placement simulator: technical note 显示文摘 | Tai BL Rooney D Stephenson F | 2015 | J Neurosurg2015，123，4： | 1 |
| 15 | Total parenteral nutrition supplementation with glutamine improves survival after gut ischemia/reperfusion 显示文摘 | Ikeda S Zarzaur BL Johnson CD et d | 2002 | J Parenter Enteral Nutr2002，26，： | 1 |
| 16 | Anomalous aortic origin of coronary arteries显示文摘 | Kimbris D Iskandrian AS Segal BL | 1976 | Circulation1976，58，3： | 1 |
| 17 | Necrotizing ente- rocolitis and the role of anemia of prematurity 显示文摘 | SINGH R SHAH BL FRANTZ I D 3RD | 2012 | Semin Perinatol2012，36，4： | 1 |
| 18 | Sublethal tox-ic effects and induction of glutathione S-transferase by short chain chlorinated paraffins(SCCPs)and C-12 al-kane (dodecane) in Xenopus laevis frog embryos显示文摘 | Bur Bláha L Vr?ková D | | 0，，： | 1 |
| 19 | Oxidation of austenitic and ferritic/martensitic alloys in supercritical water显示文摘 | GMEZ-BRICEO D BLZQUEZ F SEZ-MADERUELO A | 2013 | Journal of Supercritical Fluids2013，78，5： | 1 |
| 20 | A hybrid activated car- bon-manganese dioxide capacitor using a mild aqueous electrolyte 显示文摘 | BROUSSE T TOUPIN M Bl~LANGER D | 2004 | J Electrochem Soc2004，151，： | 1 |
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