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| 1 | Discovery and development of NA-1 for the treatment of acute ischemic stroke显示文摘击包括 excitotoxicity,离子的不平衡,发炎,氧化压力和 apoptosis 创造多重 signaing 小径的复杂相互影响。有很少的治疗,被显示了在急性击有益。最近的调查结果提供了卓见进 ischemic 击的 pathophysiology 和机制,补充传统的 glutamate 假设:在 PSD95 和 GluN2B 之间的分子的相互作用在调停击的 excitotoxicity 作为一个犯人被识别了,导致 NA-1 的发现,破坏那个相互作用,,的肽为急性击的处理的一个有势力 neuroprotective 代理人。在这评论,我们从凳子描述它的发信号的串联,它的治疗学的干预的目标和它的翻译到临床的试用。 | Beatrice BALLARIN Michael TYMIANSKI | 2018 | Acta Pharmacologica Sinica2018，39，5： | 26 |
| 2 | Pancreatic metastases from renal cell carcinoma:The state of the art显示文摘Pancreatic metastases are rare,with a reported incidence varying from 1.6%to 11%in autopsy studies of patients with advanced malignancy.In clinical series,the frequency of pancreatic metastases ranges from 2%to 5%of all pancreatic malignant tumors.However,the pancreas is an elective site for metastases from carcinoma of the kidney and this peculiarity has been reported by several studies.The epidemiology,clinical presentation,and treatment of pancreatic metastases from renal cell carcinoma are known from singleinstitution case reports and literature reviews.Thereis currently very limited experience with the surgical resection of isolated pancreatic metastasis,and the role of surgery in the management of these patients has not been clearly defined.In fact,for many years pancreatic resections were associated with high rates of morbidity and mortality,and metastatic disease to the pancreas was considered to be a terminal-stage condition.More recently,a significant reduction in the operative risk following major pancreatic surgery has been demonstrated,thus extending the indication for these operations to patients with metastatic disease. | Roberto Ballarin Mario Spaggiari Nicola Cautero Nicola De Ruvo Roberto Montalti Cristina Longo Anna Pecchi Patrizia Giacobazzi Giuseppina De Marco Giuseppe D’Amico Giorgio Enrico Gerunda Fabrizio Di Benedetto | 2011 | World Journal of Gastroenterology2011，17，43： | 21 |
| 3 | Surgery in biliary lithiasis: from the traditional “open” approach to laparoscopy and the“rendezvous” technique显示文摘BACKGROUND:According to the current literature, biliary lithiasis is a worldwide-diffused condition that affects almost 20% of the general population. The rate of common bile duct stones(CBDS) in patients with symptomatic cholelithiasis is estimated to be 10% to 33%, depending on patient's age.Compared to stones in the gallbladder, the natural history of secondary CBDS is still not completely understood. It is not clear whether an asymptomatic choledocholithiasis requires treatment or not. For many years, open cholecystectomy with choledochotomy and/or surgical sphincterotomy and cleaning of the bile duct were the gold standard to treat both pathologies. Development of both endoscopic retrograde cholangiopancreatography(ERCP) and laparoscopic surgery,together with improvements in diagnostic procedures, influenced new approaches to the management of CBDS in association with gallstones.DATA SOURCES:We decided to systematically review the literature in order to identify all the current therapeutic options for CBDS. A systematic literature search was performed independently by two authors using Pub Med, EMBASE, Scopus and the Cochrane Library Central.RESULTS:The therapeutic approach nowadays varies greatly according to the availability of experience and expertise in each center, and includes open or laparoscopic common bile duct exploration, various combinations of laparoscopic cholecystectomy and ERCP and combined laparoendoscopic rendezvous.CONCLUSIONS:Although ERCP followed by laparoscopic cholecystectomy is currently preferred in the majority of hospitals worldwide, the optimal treatment for concomitant gallstones and CBDS is still under debate, and greatly varies among different centers. | Giuseppe Tarantino Paolo Magistri Roberto Ballarin Giacomo Assirati Antonio Di Cataldo Fabrizio Di Benedetto | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，6： | 18 |
| 4 | Long term follow-up and outcome of liver transplantation from hepatitis B surface antigen positive donors显示文摘Liver transplant for hepatitis B virus(HBV) currently yields excellent outcomes: it allows to rescue patients with an HBV-related advanced liver disease, resulting in a demographical modification of the waiting list for liver transplant. In an age of patient-tailored treatments, in liver transplantation as well the aim is to offer the best suitable graft to the patient who can benefit from it, also expanding the criteria for organ acceptance and allocation. With the intent of developing strategies to increase the donor pool, we set-up a multicenter study involving 3 Liver Transplant Centers in Italy: patients undergoing liver transplantation between March 03, 2004, and May 21, 2010, were retrospectively evaluated. 1408 patients underwent liver transplantation during the study period, 28(2%) received the graft from hepatitis B surface antigen positive(HBs Ag)-positive deceased donors. The average follow-up after liver transplantation was 63.7 mo [range: 0.1-119.4; SD ± 35.8]. None Primary nonfunction, re-liver transplantation, early or late hepatic artery thrombosis occurred. The 1-, 3-and 5-year graft and patient survival resulted of 85.7%, 82.1%, 78.4%. Our results suggest that the use of HBs Agpositive donors liver grafts is feasible, since HBV can be controlled without affecting graft stability. However, the selection of grafts and the postoperative antiviral therapy should be managed appropriately. | Roberto Ballarin Alessandro Cucchetti Francesco Paolo Russo Paolo Magistri Matteo Cescon Umberto Cillo Patrizia Burra Antonio Daniele Pinna Fabrizio Di Benedetto | 2017 | World Journal of Gastroenterology2017，23，12： | 4 |
| 5 | Treatment of idiopathic membranous nephropathy with the combination of steroids,tacrolimus and mycophenolate mofetil:results of a pilot study显示文摘 | Ballarin J Poveda R Ara J | 2007 | Nephrol Dial Transplant2007，22，11： | 1 |
| 6 | Human Doppel and prion protein share common membrane microdomains and internalization pathways显示文摘 | MASSIMINO M L BALLARIN C BERTOLI A | 2004 | Int J Biochem Cell Biol2004，36，10： | 1 |
| 7 | Population based drug induce dagranu loeytosis显示文摘 | Vidal X Ballarin E Laporte J R | 2005 | ArchIntern Med2005，165，： | 1 |
| 8 | Exposure of the clam Tapes phillpplnarum to 4-nonylphenol : changes in anti-oxidant en- zyme activities and rc-burrowing capability 显示文摘 | MATOZZO V BALLARIN L MARIN M G | 2004 | Mar Pollut Bull2004，48，56： | 1 |
| 9 | A novel potentiometric sensor for L-ascorbic acid based on molecularly imprinted polypyrrole 显示文摘 | TONELLI D BALLARIN B GUADAGNINI L | 2011 | Electrochimica Acta2011，56，20： | 1 |
| 10 | Primary cultures of astrocytes from fetal bovine brain 显示文摘 | Ballarin C Peruffo A | 2012 | Methods Mol Biol2012，814，： | 1 |
| 11 | Long-term outcomes of lgA nephropathy presenting with minimal or no protein- Hria显示文摘 | Gutierrez E Zamora I Ballarin JA | 2012 | J Am Soc Nephrol2012，23，10： | 1 |
| 12 | Influence of cadmium on the morphology and functionality of haemoeytes in the compound ascidian Botryllus schlosseri 显示文摘 | Nicola Franchi Loriano Ballarin | 2013 | Comparative Biochemistry and Physiology Part C2013，158，： | 1 |
| 13 | Haematological parameters in Umbrina cirrosa (Teleostei, Sciaenidae): a comparison between diploid and triploid specimens显示文摘 | Ballarin L Dall'Oro M Bertotto D | 2004 | Comp Biochem Physiol2004，138，： | 1 |
| 14 | Investiga- tion on the dyeing power o{ some organic natural corn pounds for a green approach to hair dyeing显示文摘 | J Carla Boga Camilla Delpivo Barbara Ballarin | 2013 | Dyes andPigments2013，97，： | 1 |
| 15 | Treatment of idiopathicmembranous nephropathy with the combination of steroids,tacrolimus and mycophenolate mofetil:results of a pilotstudy显示文摘 | Ballarin J Poveda R Ara J | 2007 | Nephrol Dial Transplant2007，22，11： | 1 |
| 16 | Agranulocytosis associated with calcium dobesilate,clinical course and risk estimation with the case control and the case population approaches显示文摘 | Ibanez L Ballarin E | 2000 | Eur J Clin pharmacol2000，56，910： | 1 |
| 17 | Synthesis of nano-structured magnetic photocatalyst by colloidal approach andspray-drying technique显示文摘 | Costa A Ballarin B Spegni A | 2012 | Journal of Colloid and InterfaceScience2012，388，1： | 1 |
| 18 | HLA-DQA1 and PLA2R1 polymorphisms and risk of idiopathic membranous nephropathy显示文摘 | Bullich G Ballarin J Oliver A | 2014 | Clin J Am Soc Nephrol2014，9，2： | 1 |
| 19 | Dopamine D1 and D2 receptors visualized in MPTP treated C57 mice by in vitro autoradiography:lack of evidence of receptor modifications in Parkinsonian mice显示文摘 | Camps M Amrosio S Ballarin M | 1989 | Pharmacol Toxicol1989，65，： | 1 |
| 20 | Agranulocytosis associated with calcium dobesilate clinical course and risk estimation with the case control and the case population approaches显示文摘 | Ibanez L Ballarin E | 2000 | Eur J Clin pharmacol2000，56，910： | 1 |
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