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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Framing effects within the ethical decision making process of consumers显示文摘 | Bateman C R Fraedrich J P Iyer R | 2002 | Journal of Business Ethics2002，36，12： | 1 |
| 3 | Mass Spectral Analyses of Microcystins from Toxic Cyanobacteria Using on-line Chromatographic and Electrophoretic Separations显示文摘 | Bateman K P Thibault P Douglas D J | 1995 | J Chromatogr A1995，712，： | 1 |
| 4 | Global strate- gy for asthma management and prevention: GINA executive summary 显示文摘 | BATEMAN E D HURD S S BARNES P J | 2008 | Eur Respir J2008，31，1： | 1 |
| 5 | Bound and path effects in double and triple bounded dichotomous choice contingent valuation 显示文摘 | Langford I H Jones A P | 2001 | Resources and Energy Economics2001，23，： | 1 |
| 6 | Global strategyfor asthma management and prevention:GINA executivesummary显示文摘 | Bateman E D Hurd S S Barnes P J | 2008 | Eur Respir J2008，31，1： | 1 |
| 7 | Global strategy for asthma management and prevention: GI- NA executive summary显示文摘 | Bateman E D Hurd S S Barnes P J | 2008 | Eur Respir J2008，31，1： | 1 |
| 8 | Mid- to late-Holocene coastal dune event stratigraphy for the north coast of Northern Ireland显示文摘 | Wilson P McGourty J Bateman M D | 2004 | The Holocene2004，14，40： | 1 |
| 9 | Antibodies to type Ⅱ collagen in SLE : a role in the pathogenesis of deforming arthristis 显示文摘 | Choi E K Gatenby P A Bateman J F | 1990 | Immunol Cell Biol1990，，： | 1 |
| 10 | Reducing gain-loss asymmetry: A virtual reality choice experiment valuing land use change 显示文摘 | Bateman I J Brett H Day Andrew P Jones | 2009 | Journal of Environmental Economics and Management2009，58，： | 1 |
| 11 | The Pfam protein families database 显示文摘 | Punta M Coggill P C Eberhardt R Y Mistry J Tate J Boursnell C Pang N Forslund K Ceric G Clements J Hcger A Holm L Sonnhammer E L Eddy S R Bateman A Finn R D | 2012 | Nucleic Acids Research2012，40，： | 1 |
| 12 | Global strategy for asthma management and prevention:GINA executive summary显示文摘 | BATEMAN E D HURD S S BARNES P J | 2008 | Eur Respir J2008，31，1： | 1 |
| 13 | An attrac- tion-selection-attrition theory of online community size and resil- ience 显示文摘 | BUTLER B S BATEMAN P J GRAY P H | 2014 | Mis Quarterly2014，38，3： | 1 |
| 14 | Development of strategies for the incorporation of microbial pesticides into the integrated management of locusts and grasshoppers显示文摘 | Lomer C J Bateman R P de Groote H | 1999 | Journal of Agricultural and Forest Entomology1999，1，： | 1 |
| 15 | Developmental bases for key innovations in the seed-plant microgametophyte 显示文摘 | Rudall P J Bateman R M | 2007 | Trends Plant Sci2007，12，7： | 1 |
| 16 | Appling GIS to environmental and resource economics显示文摘 | Bateman I J Jones A P Lovett A A | 2002 | Environmental and Resource Economics2002，22，： | 1 |
| 17 | Org Identification and structural analysis of synthetic oligosaccharides of shigella sonnei using MALDI-TOFMS显示文摘 | Harvey D J Rudd P M Bateman R H | 1994 | Mass Spectrom1994，29，： | 1 |
| 18 | On the calculation of the water particle kinematics arising in a directionally spread wavefield显示文摘 | Bateman W J D Swan C Taylor P H | 2003 | Journal of Computational Physics2003，186，： | 1 |
| 19 | Mass spectral analyses of mlerocystins from toxic cyanobacteria using on-line chromatographic and electrophoretic separations 显示文摘 | Bateman KP Thibault P Douglas D J | 1995 | J Chromatogr A1995，712，： | 1 |
| 20 | Meningioma resectionin the elderly: nationwide inpatient sample 显示文摘 | Bateman BT Spellman J P Gutin PH | 2005 | Neurosurgery2005，57，5： | 1 |
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