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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 3 | Corn growth and nitrogen uptake with furrow irrigation and fertilizer bands显示文摘 | BENJAMIN J G PORTER L K DUKE H R AHUJA L R | 1997 | Agronomy Journal1997，89，： | 1 |
| 4 | Basic fibroblast growth factor-induced cell death is effected through sustained activation of p38MAPK and up-regulation of the death receptor p75NTR显示文摘 | Andrew J K W Benjamin C D James R B | 2004 | J Biol Chem2004，279，47： | 1 |
| 5 | What is the proper threshold for platelet transfusion in patients with chemotherapy- induced thrombocytopenia 显示文摘 | Benjamin R J Anderson K C | 2002 | Critical Rev Oncol Hematol2002，42，： | 1 |
| 6 | Corn growth and nitrogen uptake with furrow irrigation and fertilizer bands显示文摘 | Benjamin J G Porter L K Duke H R | 1997 | Agronomy Journal1997，89，4： | 1 |
| 7 | Tyrosine cross-links : molecular basis of gluten structure and function 显示文摘 | Tilley K A Benjamin R E Bagorogoza K E | 2001 | Journal of Agricultural and Food Chemistry2001，，49： | 1 |
| 8 | TRPC channels determine hu- man keratinocyte differentiation : new insight into basal cellcarcinoma 显示文摘 | Benjamin B Vlehen K Morad R | 2008 | Cell Calcium2008，43，5： | 1 |
| 9 | Corn growth and nitro-gen uptake with furrow irrigation and fertilizer bands显示文摘 | Benjamin J G Porter L K Duke H R | 1997 | Agronomy Journal1997，89，4： | 1 |
| 10 | Phenoloxidase from shrimp(Penaeus setiferus) : purification and some properties显示文摘 | Benjamin K S Maurice R M Steven O W | 1987 | Journal of Agricultural and Food Chemistry1987，，35： | 1 |
| 11 | Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts显示文摘 | Ogasawara K Benjamin J Takaki R | | 0，，： | 1 |
| 12 | Tyrosine cross-links: molecular basis of gluten structure and function显示文摘 | Tilley K A Benjamin R E | 2001 | J Agricultural Food Chemistry2001，49，5： | 1 |
| 13 | Chronic ethanol and nicotine interaction on rat tissue antioxidant defense system显示文摘 | Kazim Husain Benjamin R Scott Sathya K | 2001 | Alcohol2001，25，： | 1 |
| 14 | The interrelationship between markets for new and ud durable goods显示文摘 | BENJAMIN D K KORMENDI R C | 1974 | Journal of Law and Eco- nomics1974，17，： | 1 |
| 15 | Local dispersal promotes biodiversity in a real-life game of rock-paper-scissors 显示文摘 | BENJAMIN K MARGARET A R MARCUS W F | 2002 | Nature2002，418，6894： | 1 |
| 16 | Corn growth and nitrogen uptake with furrow irrigation and fertilizer bands显示文摘 | BENJAMIN J G PORTER L K DUKE H R | 1997 | Agronomy Journal1997，89，4： | 1 |
| 17 | Hydrogen peroxide enhanced photocatalytic oxidation of microystin-LR using titanium dioxide显示文摘 | BENJAMIN J C LINDA A L PETER K R | 2000 | Applied Catalysis B: Environmental2000，25，1： | 1 |
| 18 | Corn growth and nitrogen uptake with furrow irrigation and fertilizer bands显示文摘 | Benjamin J G Porter I K Duke H R | 1997 | Agron Journal1997，89，： | 1 |
| 19 | Tyrosine crosslinks:molecular basis of gluten structure and function显示文摘 | Tilley K A Benjamin R E Bagorogoza K E | 2001 | Journal of Agricultural and Food Chemistry2001，49，： | 1 |
| 20 | Nitrogen movement with furrow irrigation method and fertilizer band placement显示文摘 | Benjamin J G Porter L K Duke H R | 1998 | Soil Sci Soc Am J1998，62，4： | 1 |
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