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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Utility of endoscopic ultrasound and endoscopy in diagnosis and management of hepatocellular carcinoma and its complications: What does endoscopic ultrasonography offer above and beyond conventional cross-sectional imaging?显示文摘Hepatocellular carcinoma constitutes over 90% of the primary liver tumors, the rest being cholangiocarcinoma. It has an insidious presentation, which is responsible for the delayed presentation. Hence, the management strategy relies on screening to diagnose it an early stage for curative resection and/or treatment with local ablative techniques or chemotherapy. However, even with different screening programs, more than 60% of tumors are still detected at an advanced stage, leading to an unchanged mortality rate, thereby implying a room for improvement in the screening and diagnostic process. In the last few years, there has been evolution of utility of endoscopy, specifically endoscopic ultrasonography along with Fine needle aspiration, for this purpose, which we comprehensively review in this article. | Mohit Girotra Kaartik Soota Amaninder S Dhaliwal Rtika R Abraham Mauricio Garcia-Saenz-de-Sicilia Benjamin Tharian | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，2： | 5 |
| 3 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 4 | Knowledge Engineering,Principles and Methods显示文摘 | S TUDER R BENJAMINS V R FENSEL D | 1998 | Data and Knowledge Engineering1998，25，12： | 1 |
| 5 | Adriamycin cardiomyopathy: risk factors显示文摘 | MINOW R A BENJAMIN R S LEE E T | 1977 | Cancer1977，39，4： | 1 |
| 6 | Adsorption of natural organic matter (NOM) on iron oxide: Effects on NOM composition and formation of organo-halide compounds during chlorination显示文摘 | Korshin G V Benjamin M M Sletten R S | 1997 | Water Research1997，31，7： | 1 |
| 7 | Time to peak force is related to frontal plane landing kinematics in female athletes显示文摘 | Christopher R Benjamin R Jason S | 2012 | Physical Therapy in Sport2012，13，2： | 1 |
| 8 | The evolution of the mesoseale enviromnent of severe h>eal storms:Preliminary modeling results显示文摘 | ANTHES R A KUO Y H BENJAMIN S G | 1982 | Mon Wea Rev1982，110，： | 1 |
| 9 | Prevalence,Clinical features and Prognosis of Diastolic Heart Failure:an Epidemiologic Perspective显示文摘 | Vasan R S Benjamin E J Levy D | 1995 | J Am Coll Cardiol1995，26，7： | 1 |
| 10 | Lung injury induced by sepsis: les- sons learned from large animal models and future directions for treatment 显示文摘 | Benjamin S Shreyas R Louis AG | 2011 | Expert Rev Anti infect Ther2011，9，12： | 1 |
| 11 | Sorption and filtration of metals using iron-oxide-coated sand 显示文摘 | Benjamin M M Sletten R S | 1996 | Water Res1996，30，11： | 1 |
| 12 | The realm of mi- crobial lipases in biotechnology显示文摘 | Pandey A Benjamin S Soeeol C R | 1999 | Biotechnol Appl Bio- chem1999，，29： | 1 |
| 13 | Comparison of intrave- nously administered dezoeine and morphine for postoperative pain 显示文摘 | VERA S S GEORGE H BENJAMIN R | 1987 | Clin J Pain1987，2，4： | 1 |
| 14 | The realm of microbial lipases in biotechnology 显示文摘 | PANDEY A BENJAMIN S SOOCOL C R | 1999 | Biotechnol Appl Biochem1999，29，： | 1 |
| 15 | The realm of microbial lipases in biotechnology 显示文摘 | PANDEY A BENJAMIN S SOCCOL C R | 1999 | Biotechnology and Applied Biochemistry1999，29，： | 1 |
| 16 | Model equations for long waves in nonlinear dispersive systems 显示文摘 | Benjamin T B F R S Bona J L Mahony J J | 1972 | Philos Trans R Soc London: Ser A1972，272，： | 1 |
| 17 | Photocatalytic degradation of organic pollutants显示文摘 | Ameta R Benjamin S Ameta A | 2013 | Materials Science Forum2013，734，1： | 1 |
| 18 | Adsorption of natural organic matter (NOM) on iron oxide: effects on NOM composition and formation of organo-halide compounds during chlorination显示文摘 | Korshin G V Benjamin M M Sletteh R S | 1997 | Water Research1997，31，7： | 1 |
| 19 | Optical service over the intelligent optical network 显示文摘 | Benjamin D Trudel R Shew S | 2001 | IEEE Communications Magazine2001，39，9： | 1 |
| 20 | Triterpenoids from salvia deserta 显示文摘 | GIUSEPPE S MAURIZIO B BENJAMIN R | 1987 | Phytochemistry1987，26，12： | 1 |
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