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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 3 | Basic considerations in the use of coded excitation for color flow imaging applications 显示文摘 | LAMBOUL B BENNETT M ANDERSON T | 2009 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control2009，56，4： | 1 |
| 4 | SP600125,an anthrapyrazolone inhibitor of Jun N-terminal kinase显示文摘 | BENNETT B L SASAKI D T MURRAY B W | 2001 | Proc Natl Acad Sci USA2001，98，13： | 1 |
| 5 | SP600125, an anthrapyrazolone inhibitor of c-Jun N terminal Kinase显示文摘 | Bennett B L Sasaki D T Murray B W | 2001 | Proc Natl Acad Sci USA2001，98，13： | 1 |
| 6 | SP600125, an anthrapyrazolone inhibitor of Jun N- terminal kinase显示文摘 | Bennett B L Sasaki D T Murray B W | 2001 | Proc Natl Acad Sei USA2001，98，13： | 1 |
| 7 | Enzyme-linked immunosorbent assay for detection of zearalenone in corn,wheat, and pig feed:collaborative study 显示文摘 | Bennett G A Nelsen T C Miller B M | 1994 | J AOAC Int1994，77，6： | 1 |
| 8 | CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression显示文摘 | Carreno B M Bennett F Chau T A | 2000 | J Immunol2000，165，： | 1 |
| 9 | Robust electrical spin injection into a semiconductor heterostructure显示文摘 | JONKER B T PARK Y D BENNETT B R | 2001 | Phys Rev B2001，62，： | 1 |
| 10 | Expression of acid invertase gene controls of sugar composition in tomato (Lycopersion) fruit 显示文摘 | Klann M E Chetelat T R Bennett A B | 1993 | Plant Physiol1993，103，： | 1 |
| 11 | Basic considerations in the use of coded excitation for color flow imaging applications 显示文摘 | Lamboul B Bennett M Anderson T et a| | 2009 | IEEE Transactions on Ultrasonics Ferroelectric and Frequency Control2009，56，4： | 1 |
| 12 | Enzyme-linked immunosorbent assay for detection of zearalenone in corn, wheat, and pig feed, collaborative study 显示文摘 | Bennett G A Nelsen T C Miller B M | 1995 | J AOAC Int1995，77，6： | 1 |
| 13 | 'Conditioned Air': Evaluating an environmentally preferable service 显示文摘 | Bennett E B Graedel T E | 2000 | Environmental Science &Technology2000，34，4： | 1 |
| 14 | Arabidopsis AUX1 gene, a permease like regulator of root gravitropism显示文摘 | BENNETT M J MARCHANT A GREEN H G MAY S T WARD S P MILLNER P A WALKER A R SCHULZ B FELDMANN K A | 1996 | Science1996，273，： | 1 |
| 15 | SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase 显示文摘 | Bennett BL Dennis T Sasaki B | 2001 | Cell Biol2001，98，13： | 1 |
| 16 | Planned folding and Colorado River riparian trade-offs downstream from Glen Canyon Dam,Arizona显示文摘 | Stevens L E Ayers T J Bennett J B | | 0，，03： | 1 |
| 17 | The tu8 mutation of Arabidopsis thaliana encoding a heterochromatin protein 1 homolog causes defects in the induction of secondary metabolite biosynthesis 显示文摘 | Bennett R N Wenke T Freudenberg B | 2005 | Plant Biology2005，，7： | 1 |
| 18 | Expression of acid invertase gene control sugar composition in tomato (Lycopersicon) fruit 显示文摘 | Klann E W Chetelat R T Bennett A B | 1993 | Plant Physiol1993，103，： | 1 |
| 19 | Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918显示文摘 | Nelson M I Viboud C Simonsen L Bennett R T Griesemer S B St George K | 2008 | PLoS Pathog2008，4，10： | 1 |
| 20 | Developing competency-based methods for near-real-time air combat problem solving assessment显示文摘 | Bennett Jr W Sehreiber B T Andrews D H | 2002 | Computers in Human Behavior2002，18，6： | 1 |
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