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| 1 | Helicobacter pylori arginase mutant colonizes arginase Ⅱ knockout mice显示文摘AIM: To investigate the role of host and bacterial arginases in the colonization of mice by Helicobacter pylori (H.pylori).METHODS: H.pylori produces a very powerful urease that hydrolyzes urea to carbon dioxide and ammonium,which neutralizes acid.Urease is absolutely essential to H.pylori pathogenesis;therefore,the urea substrate must be in ample supply for urease to work efficiently.The urea substrate is most likely provided by arginase activity,which hydrolyzes L-arginine to L-ornithine and urea.Previous work has demonstrated that H.pylori arginase is surprisingly not required for colonization of wild-type mice.Hence,another in vivo source of the critical urea substrate must exist.We hypothesized that the urea source was provided by host arginase Ⅱ,since this enzyme is expressed in the stomach,and H.pylori has previously been shown to induce the expression of murine gastric arginase Ⅱ.To test this hypothesis,wild-type and arginase (rocF) mutant H.pylori strain SS1 were inoculated into arginase Ⅱ knockout mice.RESULTS: Surprisingly,both the wild-type and rocF mutant bacteria still colonized arginase Ⅱ knockout mice.Moreover,feeding arginase Ⅱ knockout mice the host arginase inhibitor S-(2-boronoethyl)L-cysteine (BEC),while inhibiting > 50% of the host arginase Ⅰ?activity in several tissues,did not block the ability of the rocF mutant H.pylori to colonize.In contrast,BEC poorly inhibited H.pylori arginase activity.CONCLUSION: The in vivo source for the essential urea utilized by H.pylori urease is neither bacterial arginase nor host arginase Ⅱ;instead,either residual host arginase Ⅰ?or agmatinase is probably responsible. | Songhee H Kim Melanie L Langford Jean-Luc Boucher Traci L Testerman David J McGee | 2011 | World Journal of Gastroenterology2011，17，28： | 3 |
| 2 | Decreased resistin expression in mice with different sensitivities to a high-fat diet显示文摘 | Le Lay S L Boucher J Rey A | 2001 | Biochem Biophys Res Commun2001，289，： | 1 |
| 3 | Radiographic evaluation ofthe prevalence and technical quality of root canal treatment in a French subpopulation显示文摘 | Boucher Y Matossian L Rilliard F | 2002 | Int Endod J2002，35，3： | 1 |
| 4 | Processing of high-frequency muhibeam echo sounder data for seafloor charac- terization 显示文摘 | HELLEQUIN L BOUCHER J | 2003 | IEEE Journal of Oceanic Engineering2003，28，1： | 1 |
| 5 | Annexin V binding to plas- ma membrane predicts the quality of human cryopreserved spermatozoa显示文摘 | Sion B Janny L Boucher D | 2004 | International Journal of Andrology2004，27，： | 1 |
| 6 | Amino acid nutrition and immune function in tumour-bearing rats:a comparison of glutamine-,arginine-and ornithine 2-oxoglutarate-supplemented diets显示文摘 | Robinson L E Bussiere F I Le Boucher J | 1999 | Clin Sci (Lond)1999，97，： | 1 |
| 7 | Phase relations pertaining to the solvent winterization of peanut oil in acetone-hexane mix- tures显示文摘 | Boucher R E Skau E L | 1951 | J Am Oil Chem SOe1951，28，12： | 1 |
| 8 | Radiographic evaluation of the prevalence and technical quality of root canal treatment in a French subpopulation 显示文摘 | Boucher Y Matossian L Rilliard F | 2002 | Int Endodon J2002，35，3： | 1 |
| 9 | Whole blood real-time quantitative PCR for cytomegalovirus infection follow-up in transplant recipients显示文摘 | Garrigue I Boucher S Couzi L | 2006 | J Clin Virol2006，36，1： | 1 |
| 10 | Radical copolymerization of vinylidene fluoride with perfluoroalkylvinyl ethers显示文摘 | Otazaghine B Sauguit L Boucher M | 2005 | European Polymer Joural2005，41，8： | 1 |
| 11 | The infared spectra of metalloporphyrins(4000 ~ 160cm-1)显示文摘 | Boucher L J Katz J J | 1967 | J Am Chem Soc1967，89，6： | 1 |
| 12 | Radiographic evaluation of the prevalence and technical quality of root canal treatment in a French subpopulation显示文摘 | Boucher Y Matossian L Rilliard F | 2002 | Int Endod J2002，35，3： | 1 |
| 13 | Effects of trimetazidine on ischemic contracture in isolatecl perfused rat hearts显示文摘 | Boucher F R Hearse D J Opie L H | 1994 | J Cardiovasc Pharmacol1994，24，1： | 1 |
| 14 | Effects of trimetazidine on ischemic contracture in isolated pedused rat heats显示文摘 | BOUCHER R HEARSE D J OPIE L H | 1994 | J Cardiovasc Pharmacol1994，24，1： | 1 |
| 15 | Molecular genetics of pathogenicity determinants of Pseudomonas solanacearum with special emphasis on hrp genes 显示文摘 | Boucher C A Gough C L Arlat M | 1992 | Annu Rev Phytopathol1992，30，： | 1 |
| 16 | Processing of High-frequency Multibeam Echo Sounder Data for Seafloor Characterization显示文摘 | Hellequin L Boucher J M Lurton X | 2003 | IEEE Journal of O- ceanic Engineering2003，28，1： | 1 |
| 17 | Frequency-specific audiometry using steady-state responses显示文摘 | LINS O G PICTON T W BOUCHER B L | 1996 | Ear Hear1996，17，： | 1 |
| 18 | Radiographic evaluation of the prevalence and technical quality of root canal treatment in a French subpopulation显示文摘 | BOUCHER Y MATOSSIAN L RILLIARD F | 2002 | Int Endod J2002，35，3： | 1 |
| 19 | Radiographic e-valuation of the prevalence and technical quality of root canal treatment in a French subpopulation 显示文摘 | Boucher Y Matossian L Rilliard F | 2002 | Int Endod2002，35，： | 1 |
| 20 | Inhibitor coordination interactions in the binuclear manganese cluster of arginase 显示文摘 | Cama E Pethe S Boucher J L | 2004 | Biochemistry2004，43，28： | 1 |
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