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| 1 | Endoscopic ultrasound evaluation in the surgical treatment of duodenal and peri-ampullary adenomas显示文摘AIM:To investigate endoscopic ultrasound(EUS) for predicting depth of mucosal invasion and to analyze outcomes following endoscopic and transduodenal resection.METHODS:Records of 111 patients seen at our institution from November 1999 to July 2011 with the postoperative pathological diagnosis of benign ampullary and duodenal adenomas were reviewed.Records of patients who underwent preoperative EUS for diagnostic purposes were identified.The accuracy of EUS in predicting the absence of muscular invasion was assessed by comparing EUS reports to the final surgical pathological results.In addition,the incidence of the post-operative complications over a period of 30 d and the subsequent long-term outcome(recurrence) over a period of 30 mo associated with endoscopic and transduodenal surgical resection was recorded,compared and analyzed.RESULTS:Among 111 patients with benign ampullary and duodenal adenomas,47 underwent preoperative EUS for 29 peri-ampullary lesions and 18 duodenal lesions.In addition,computed tomography was performed in 18 patients,endoscopic retrograde cholangio-pancreatography in 10 patients and esophagogastroduodenoscopy in 22 patients.There were 43 patients with sporadic adenomas and 4 patients with familial adenomatous polyposis(FAP)/other polyposis syndromes.In 38(81%,P < 0.05) patients,EUS reliably identified absence of submucosal and muscularis invasion.In 4 cases,EUS underestimated submucosal invasion that was proven by pathology.In the other 5 patients,EUS predicted muscularis invasion which could not be demonstrated in the resected specimen.EUS predicted tumor muscularis invasion with a specificity of 88% and negative predictive value of 90%(P < 0.05).Types of resection performed included endoscopic resection in 22 cases,partial duodenectomy in 9 cases,transduodenal ampullectomy with sphincteroplasty in 10 cases and pancreaticoduodenectomy in 6 cases.The main post-operative final pathological results included villous adenoma(n = 5),adenoma(n = 8),tubulovillous adenoma(n = 10),tubular adenoma(n = 20) and hyperplastic polyp(n = 2).Among the 47 patients who underwent resection,8(17%,5 of which corresponded to surgical resection) developed post-procedural complications which included retroperitoneal hematoma,intra-abdominal abscess,wound infection,delayed gastric emptying and prolonged ileus.After median followup of 20 mo there were 6 local recurrences(13%,median follow-up = 20 mo) 4 of which were in patients with FAP.CONCLUSION:EUS accurately predicts the depth of mucosal invasion in suspected benign ampullary and duodenal adenomas.These patients can safely undergo endoscopic or local resection. | Lilian C Azih Brett L Broussard Milind A Phadnis Martin J Heslin Mohamad A Eloubeidi Shayam Varadarajulu Juan Pablo Arnoletti | 2013 | World Journal of Gastroenterology2013，19，4： | 13 |
| 2 | The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition显示文摘在人的不孕病人的精子在场的最普通的损害之一是精子鸡蛋识别的自发的失败。尽管这个唯一的细胞的相互作用现在能被象 intracytoplasmic 精子注射(ICSI ) 那样的帮助繁殖策略乐意地绕过,最近的大规模流行病学的研究鼓励了这种技术的小心的使用并且为对为有缺点的精子鸡蛋识别负责的机制的进一步的研究加亮需要。这个领域里的以前的工作证实了为卵母细胞相互作用负责的精子领域在动态地在女繁殖的道在 epididymal 成熟和 capacitation 期间被修改以前在精子发生期间被形成。当为这些顺序的 maturational 事件的规定负责的因素无疑是复杂的时,新兴的研究识别了分子的女伴,加热吃惊蛋白质 A2 (HSPA2 ) ,,在人的精子的这些事件的一个关键管理者。HSPA2 是支持合拢,运输,和集会蛋白质建筑群的 70 kDa 热吃惊蛋白质家庭的一个充实睾丸的成员并且断然被相关与在 vitro 授精(IVF ) 成功。而且,从人的精子 proteome 减少了 HSPA2 的表示为跟随 IVF 和 ICSI 的积云矩阵疏开,精子鸡蛋识别和授精导致一个损害能力。在这评论,我们考虑在精子功能支持 HSPA2 的角色的证据并且探索它被在不肥沃的病人的精子弄空的潜在的机制。进管理精子的分子的机制的如此的信息提议小说卓见工作。 | Brett Nixon Elizabeth G Bromfield Matthew D Dun Kate A Redgrove Eileen A McLaughlin R John Aitken | 2015 | Asian Journal of Andrology2015，17，4： | 8 |
| 3 | Are sperm capacitation and apoptosis the opposite ends of a continuum driven by oxidative stress?显示文摘这章探索 capacitation 和 apoptosis 是他们的普通依赖在反应的氧种类(ROS ) 的继续的产生上加入的连接过程的可能性。根据这个模型的意见, capacitation 在当细胞内部的 ROS 产生的后果,刺激细胞内部的营地产生,禁止酷氨酸磷酸酶活动并且由白朊从精子表面在他们的移动以前提高 oxysterols 的形成,跟随他们的版本进女繁殖的道的 spematozoa 被开始。由使能够的 ROS 的继续的产生精子的人口最后压到这些房间的有限能力保护自己免受氧化应力的伤害。作为精子的 over-capacitation 导致的结果,老朽的一个状态和截断的内在的 apoptotic 串联的激活由提高的 mitochondrial ROS 产生,类脂化合物 peroxidation,活动性损失, caspase 激活和 phosphatidylserine 外表表现描绘了。后者可能在指示吞噬细胞的白血球衰老的、垂死的精子的移动应该是由 proinflammatory cytokines 的产生无伴侣的一个沉默过程是特别地重要的。这些观察表明中央角色在定义精子的生活和死亡由氧化还原作用化学玩了。这些机制的知识可以帮助我们设计新奇答案专业化房间高度支持并且保存这些的功能。 | Robert J Aitken Mark A Baker Brett Nixon | 2015 | Asian Journal of Andrology2015，17，4： | 7 |
| 4 | MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca^sup 2+^ overload and cell death显示文摘 | Aurora Arin B Mahmoud Ahmed I Luo Xiang Johnson Brett A van Rooij Eva Matsuzaki Satoshi Humphries Kenneth M Hill Joseph A Bassel-Duby Rhonda Sadek Hesham A Olson Eric N | 2012 | EN2012，，4： | 2 |
| 5 | Electrochemical oxidation of quercetin 显示文摘 | BRETT A M O GHICA M-E | 2003 | Electroanalysis2003，15，22： | 1 |
| 6 | Electrochemical oxidation of rutin显示文摘 | Ghica M E Brett A M O | 2005 | Electroanalysis2005，17，4： | 1 |
| 7 | Review: Phos- phorus removal and recovery technologies 显示文摘 | Morse G K Brett S W Guy J A | 1998 | The Sci-ence of Total Environment1998，212，： | 1 |
| 8 | A tale of two methods显示文摘 | James L R Mulaik S A Brett J M | 2006 | Organizational Research Methods2006，9，2： | 1 |
| 9 | Fungal diversity in soils and historic wood from the Ross Sea Region of Antarctica 显示文摘 | Brett E Arenza Benjamin W Helda Joel A Jurgensa Roberta L Farrell Robert A Blanchette | 2006 | Soil Biology & Biochemistry2006，38，： | 1 |
| 10 | Surveillance for enteric pathogens in a case - control study of acute diarrhea in Western Kenya显示文摘 | Brett E S Elizabeth A O Margaret C K | 2013 | Transactions of the Royal Society of Trop- ical Medicine and Hygiene2013，107，2： | 1 |
| 11 | Neural correlates of passive and active encoding and retrieval: A 3T fMRI study显示文摘 | Dove A Rowe JB Brett M | 2001 | Neuroim- age2001，13，6： | 1 |
| 12 | Femtocell architec- tures with spectrum sharing for cellular radio networks 显示文摘 | Brett K Jorma L Behnaam A | 2013 | International Journal of Advances in Engineering Sciences and Applied Mathematics2013，5，1： | 1 |
| 13 | Characterisation by EIS of ternary Mg alloys synthesized by mechanical alloying显示文摘 | CHRISTOPHER M A BRETT DIAS L TR1NDADE B FISCHER R M1ES S | 2006 | Electrochimica Acta2006，51，： | 1 |
| 14 | Radiation effects on ferroelectric thin-film memories: retention failure mechanisms显示文摘 | SCOTT J E ARAUJO C A BRETT H | 1989 | J APPI Phys1989，22，8： | 1 |
| 15 | Species-dependent effects of zooplankton on planktonic ecosystem processes in castle lake, California显示文摘 | Brett M T Wiackowski K Lubnow F S Mueller-Solger A Eller J J Goldman C R | 1994 | Ecology1994，75，8： | 1 |
| 16 | New synchronous orbits using the geomagnetieLorenz force显示文摘 | Brett S Mason A P | 2007 | Journal of Guidance Control and Dynamics2007，30，6： | 1 |
| 17 | Cooperative distributed model predictive control显示文摘 | Brett T Stewart A N Venkat J B | 2010 | Systems & Control Letters2010，2，59： | 1 |
| 18 | Automatic detection and classification of weld flaws in TOFD data using wavelet transform and support vector machines 显示文摘 | Al-Ataby A Al-Nuaimy W Brett C R | 2010 | Insight: Non-Destructive Testing and Condition Monitoring2010，52，11： | 1 |
| 19 | The run on tamiflu-should physicians prescribe on demand显示文摘 | Brett AS Zuqer A | 2005 | N Engl J Med2005，353，25： | 1 |
| 20 | Daily pattern of nitrogen excretion and oxygen consummations of sockeye salmon显示文摘 | Brett J R Zala C A | 1975 | J Fish Res Board Can1975，32，： | 1 |
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