|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 每日1次利拉鲁肽与每日2次艾塞那肽治疗2型糖尿病比较:一项为期26周的随机、平行组、多国开放标记试验(LEAD-6)显示文摘背景与大多数抗高血糖药物不同,胰高血糖素样肽-1(GLP-1)受体激动剂的药理作用依赖于葡萄糖水平,并且有助于减轻患者体重。本研究比较了利拉鲁肽(一种人GLP-1类似物)与艾塞那肽(一种基于醋酸艾塞那肽的GLP-1受体激动剂)治疗2型糖尿病的疗效和安全性。方法对于用最大耐受剂量二甲双胍或(和)磺脲仍控制不良的2型糖尿病成年患者,根据之前服用的抗糖尿病药物进行分层,并随机分配这些患者额外接受利拉鲁肽1.8mg每El1次(n=233)或艾塞那肽10μg每日2次(n=231),进行为期26周的开放标记、平行组、多国(15个国家)研究。主要终点是糖化血红蛋白(HbA1c)水平的变化,疗效分析采用意向性治疗分析。本试验在Clinical Trial.gov注册,注册号为NCT00518882。结果受试者的HbA1c平均基线水平为8.2%。与艾塞那肽相比,利拉鲁肽能显著降低HbA1c平均水平[-1.12%(s=0.08%)vs-0.79%(s=0.08%);疗效差异估计值为-0.33%,95%CI-0.47%~-0.18%;P〈0.0001],并且利拉鲁肽组有更多患者HbA1c水平低于7%(54%vs543%;OR 2.02,95%CI 1.31~3.11;P=0.0015)。利拉鲁肽降低平均空腹血糖的能力也显著优于艾塞那肽[-1.61mmol/Lb=0.20)vs-0.60mmol/L(s=0.20);疗效差异估计值为-1.01mmol/L,95%CI-1.37—-0.65;P〈0.0001],但是其降低早餐和晚餐后血糖的能力较艾塞那肽差。两种药物促进患者体重减轻的作用相似(利拉鲁肽组~3.24kg vs艾塞那肽组-2.87地)。耐受性均较好,但与艾塞那肽组相比,利拉鲁肽组患者恶心的持续时间较短(估计的治疗相关事件率比值为0.448,P〈0.0001),轻度低血糖的发生率也较低(每患者每年的事件发生数为1.93vs2.60;发生率比值为0.55,95%C10.34~0.88:P=0.0131;轻度低血糖的发生率为25.5%掷33.6%)。2例同时注射艾塞那肽和一种磺脲类药物的患者发生了严重的低血糖。结论相对于艾塞那肽每日2次,利拉鲁肽每日1次能显著改善血糖控制水平,且患者的耐受性更好。研究结果提示利拉鲁肽或许是2型糖尿病的一种治疗选择,特别是在减轻体重和低血糖风险作为主要考虑因素的情况下。 | John B Buse Julia Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde 赵乐(译) | 2009 | 世界临床医学2009，，11： | 3 |
| 2 | Twenty-five years of research on the effects of exercise training in breast cancer survivors:A systematic review of the literature显示文摘AIM:To investigate the role of exercise training the past 25 years on major physiological-psychological outcomes studied thus far in this patient population.METHODS:Pub Med, Medline Plus, the Cochrane Library, Web of Science, SportD iscus, Embase, Scorpus, and Google Scholar were searched from September to November 2013 to identify exercise training studies that used objective measurements of fitness and/or patient reported outcomes assessed pre and post-exercise training with statistical analyses performed in at least one of the following outcome measurements:Cardiorespiratory function, body composition, muscular strength, fatigue, depression, and overall quality of life. Five reviewers independently identified the studies that met the criteria for the review and discrepancies were resolved by consensus among all authors.RESULTS:Fifty-one studies were included in this review with 5 from the period between 1989-1999, 11 from 2000-2006, and 35 from 2007-2013. The evolution of study designs changed from aerobic only exercise training interventions(1989-1999), to a combination of aerobic and resistance training(2000-2006), to studies including an arm of resistance training or examining the effects of resistance training as the main mode of exercise(2007-2013). Overall, the benefits of exercise showed improvements in cardiorespiratory function, body composition, strength, and patient reported outcomes including fatigue, depression, and quality of life.CONCLUSION:Exercise training appears to be safe for most breast cancer patients and improvements in physiological, psychological, and functional parameters can be attained with regular participation in moderate intensity exercise. | Claudio L Battaglini Robert C Mills Brett L Phillips Jordan T Lee Christina E Story Marcelo GB Nascimento Anthony Carl Hackney | 2014 | World Journal of Clinical Oncology2014，5，2： | 3 |
| 3 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)显示文摘 | John B Buse Julio Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde | 2009 | The Lancet2009，，9683： | 2 |
| 4 | Myosin binding protein C:Structural abnormalities in familial hypertrophic cardiomyopathy显示文摘The muscle protein myosin binding protein C (MyBPC) is a large multi-domain protein whose role in the sarcomere is complex and not yet fully understood. Mutations in MyBPC are strongly associated with the heart disease familial hypertrophic cardiomyopathy (FHC) and these experiments of nature have provided some insight into the intricate workings of this protein in the heart. While some regions of the MyBPC molecule have been assigned a function in the regulation of muscle contraction, the interaction of other regions with various parts of the myosin molecule and the sarcomeric proteins, actin and titin, remain obscure. In additic n, several intra-domain interactions between adjacent MyBPC molecules have been identified. Although the basic structure of the molecule (a series of immunoglobulin and fibronectin domains) has been elucidated, the assembly of MyBPC in the sarcomere is a topic for debate. By analysing the MyBPC sequence with respect to FHC-causing mutations it is possible to identify individual residues or regions of each domain that may be important either for binding or regulation. This review looks at the current literature, in concert with alignments and the structural models of MyBPC, in an attempt to understand how FHC mutations may lead to the disease state. | Cecily E OAKLEY Brett D HAMBLY Paul MG CURMI Louise J BROWN | 2004 | Cell Research2004，14，2： | 2 |
| 5 | Effect of temperature and feeding regime on the specific growth rate of sockeye salmon(Oncorhynchus nerka)fry,with a consideration of size effect显示文摘 | Shelbourn J E Brett J R Shirahata S | 1973 | Journal of the Fisheries Research Board of Canada1973，30，8： | 1 |
| 6 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)显示文摘 | John B Buse Julio Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde | 2009 | The Lancet . 2009 (9683)2009，，9683： | 1 |
| 7 | Electrochemical oxidation of rutin显示文摘 | Ghica M E Brett A M O | 2005 | Electroanalysis2005，17，4： | 1 |
| 8 | 360°feedback: Accuracy, reactions, and perceptions of useful- ness显示文摘 | Brett Joan F Atwater Leanne E | 2001 | Journal of Applied Psychology2001，86，5： | 1 |
| 9 | Amplified fragment length polymorphism(AFLP) analysis of Clostridium per f ringens for epidemiological typing显示文摘 | MC LAUCHLIN J G RIPABELLI M M BRETT E J etal | 2000 | Int J Food Microbiol2000，56，1： | 1 |
| 10 | Fungal diversity in soils and historic wood from the Ross Sea Region of Antarctica 显示文摘 | Brett E Arenza Benjamin W Helda Joel A Jurgensa Roberta L Farrell Robert A Blanchette | 2006 | Soil Biology & Biochemistry2006，38，： | 1 |
| 11 | Surveillance for enteric pathogens in a case - control study of acute diarrhea in Western Kenya显示文摘 | Brett E S Elizabeth A O Margaret C K | 2013 | Transactions of the Royal Society of Trop- ical Medicine and Hygiene2013，107，2： | 1 |
| 12 | Radiation effects on ferroelectric thin-film memories: retention failure mechanisms显示文摘 | SCOTT J E ARAUJO C A BRETT H | 1989 | J APPI Phys1989，22，8： | 1 |
| 13 | A comparison of theeffect of diet extrusion or screw-press pelleting on the digesti-bility of grain protein products when fed to rainbow troutj显示文摘 | Brett G D Wayne H D David E | 2011 | Aquaculture2011，312，： | 1 |
| 14 | Effect of temperature and feeding regimes on the specific growth rate of sockeyesalmon fry (oncorhynchus nerka)with a consideration of size effect显示文摘 | Shelbourn J E Brett J R Shirahata S | 1973 | Fish Board Can1973，30，： | 1 |
| 15 | Sequence, cycles, and basin dynamics in the Silurian of the Appalachian foreland basin 显示文摘 | BRETT C E GOODMAN W M LODUCA S P | 1990 | Sedimentary Geology1990，69，34： | 1 |
| 16 | Rapid determina- tion of polyether marine toxins using liquid chromatogra- phy-multiple tandem mass spectrometry显示文摘 | PATRICIA FERN'ANDEZ PUENTE MAR'IA JOS'E FIDALGO S'AEZ BRETT HAMILTON | 2004 | Journal of Chromatography2004，1056，： | 1 |
| 17 | A method for determining the free (unbound) concentration of ten beta - laetam antibiotics in human plasma using high performance liquid chro- matography with ultraviolet detection显示文摘 | Scott E Briscoe Brett C McWhinney Jeffrey Lipman Jason A | 2012 | Journal of Chromatography B2012，907，： | 1 |
| 18 | The extent and impact of sheep pox and goat pox in the state of Maharashtra,India显示文摘 | GARNER M SAWARKAR S D BRETT E K | 2000 | Trop Anlm Health Prod2000，32，4： | 1 |
| 19 | Immunochemical identification of LMW subunits of glutenin associated with breadmaking quality of wheat flours显示文摘 | BRETT G M MILLS E N C TATHAM A S | 1993 | Theoretical and Applied Genetics1993，86，： | 1 |
| 20 | Magnetostratigraphy susceptibility of the Upper Ordovician Kope Formation, North- ern Kentucky显示文摘 | Ellwood B B Brett C E Macdonald W D | 2007 | Palaeogeography Palaeoclimatology Palaeo- ecology2007，243，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员