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| 1 | Mycophenolate mofetil for drug-induced vanishing bile duct syndrome显示文摘Amoxicillin/clavulanate is associated with liver injury, mostly of a cholestatic pattern. While outcomes are usually benign, progression to cirrhosis and death has been reported. The role of immunosuppressive therapy for patients with a protracted course is unclear. We report the case of an elderly patient who developed prolonged cholestasis secondary to amoxicillin/clavulanate. Vanishing bile duct syndrome was confirmed by sequential liver biopsies. The patient responded to prednisone treatment, but could not be weaned off corticosteroids, even when azathioprine was added. Complete withdrawal of both prednisone and azathioprine was possible by using mycophenolate mofetil, an inosine monophosphate dehydrogenase inhibitor. Sustained remission has been maintained for more than 3 years with low-dose mycophenolate mofetil. | S Simona Jakab A Brian West Dennis M Meighan Robert S Brown Jr William B Hale | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 2 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 3 | 动脉瘤性蛛网膜下腔出血患者的重症监护处理:神经危重症监护学会多学科共识会议的推荐意见显示文摘蛛网膜下腔出血(subarachnoidhemorrhage,SAH)是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏,使得治疗方法各异,可供选择的指导意见不多。现有的指南主要强调危险因素、预防、自然史以及再出血的预防,很少涉及SAH患者的重症监护问题。美国神经危重症监护学会组织了一次国际性多学科共识会议来探讨SAH的重症监护处理。根据发表的文章和研究领域,此次会议召集了来自欧洲和北美地区的神经重症监护科、神经外科、神经内科、介入神经放射科和神经麻醉科方面的专家。根据临床经验和制定实践指南方面的经验,选择4名经验丰富的神经重症监护专家组成评判委员会。应用推荐分级的评估、制定与评价(GradesofRecommendationsAssessment,DevelopmentandEvaluation,GRADE)系统进行文献回顾,结合参会者的经验、评判委员会的审评以及文献讨论产生推荐意见。应用GRADE系统制定推荐意见,其制定原则不仅强调研究资料的质量,而且还重视利弊权衡与实践转化。对SAH患者日常处理过程中面临的所有问题均提供指导和推荐意见,即使缺乏高质量的证据。 | Michael N. Diringer Thomas P. Bleck J. Claude Hemphill David Menon Lori Shutter Paul Vespa Nicolas Bruder E. Sander Connolly Jr Giuseppe Citerio Daryl Gress Daniel Hanggi Brian L. Hoh Giuseppe Lanzino Peter Le Roux Alejandro Rabinstein, Erich Schmut zhard Nino Stocchetti Jose I. Suarez Miriam Tresgiari Ming-Yuan Tseng Mervyn D. I. Vergouwen Stefan Wolf Gregory Zip fel 田飞(译) 宿 英英(译) | 2013 | 国际脑血管病杂志2013，21，5： | 5 |
| 4 | Oral Sulfonylurea Hypoglycemic Agents Prevent Ischemic Preconditioning in Human Myocardium: Two Paradoxes Revisited显示文摘 | Joseph C. Jr Cleveland Daniel R. Meldrum Brian S. Cain Anirban Banerjee Alden H. Harken | 1997 | Circulation1997，，1： | 2 |
| 5 | Hospital investment and medi- care reimbursement显示文摘 | John J Dran Jr Brian E Campbell | 1981 | Journal of Financial Research1981，1，2： | 1 |
| 6 | Nitri coxide and the cerebralcirculation显示文摘 | FARACI FM BRIAN JE JR | 1994 | Stroke1994，25，： | 1 |
| 7 | Prospects for targeting protein kinase C isoaymes in the therapy of drug-resistant cancer- an evolving story显示文摘 | O'Brian CA Ward NE Stewart JR e t al | 2001 | Cancer Metastasis Rev2001，20，12： | 1 |
| 8 | Effect of carbon monoxide on rabbit cerebral arteries显示文摘 | Brian JE Jr Heistad DD Faraci FM | 1994 | Stroke1994，25，： | 1 |
| 9 | Is Compact Growth Good for Air Quality?显示文摘 | Stone Brian Jr Adam C Mednick Tracey Holloway Scott N Spak | 2007 | Journal of the American Planning Association2007，73，4： | 1 |
| 10 | Urban Form and Thermal Efficiency: How the Design of Cities Influences the Urban Heat Island Effect显示文摘 | Stone Brian Jr Michael O Rodgers | 2001 | Journal of the American Planning Association2001，67，2： | 1 |
| 11 | Nitric oxide and the cerebral circulation显示文摘 | Faraci F M Brian J E Jr | 1994 | Stoke1994，25，3： | 1 |
| 12 | Nitric oxide and the cerebralcirculation显示文摘 | Faraci FM Brian JE Jr | 1994 | Strok1994，25，3： | 1 |
| 13 | Sodium hypochlorite accident: inadvertent injection into the maxillary sinus 显示文摘 | Ehrich DG Brian JD Jr Walker WA | 1993 | J Endod1993，19，4： | 1 |
| 14 | Linking Land use with Household Vehicle Emissions in the Central Puget Sound:Methodological Framework and Findings显示文摘 | Frank L D Jr Brian Stone Bachman W | 2000 | Transportation Research Part D2000，，5： | 1 |
| 15 | Prospects for targeting protein kinase C isozymes in the therapy of drug-resistant canceran evolving story显示文摘 | O'Brian CA Ward NE Stewart JR | 2001 | Cancer Metastas Rev2001，20，12： | 1 |
| 16 | Hemodilution, cerebral 02 delivery, and cerebral blood flow: a study using hyperbaric oxygenation显示文摘 | Tomiyama Y Jansen K Brian JE Jr | 1999 | Am J Physiol1999，276，42： | 1 |
| 17 | Pathogenesis of bronchopulmonary dysplasia显示文摘 | Don Hayes Jr David J Feola Brian S Murphy | 2010 | Respiration2010，79，： | 1 |
| 18 | Prospects for targeting pro- tein kinase C isozymes in the therapy of drug-resistant cancer--an e- volving story显示文摘 | O' Brian CA Ward NE Stewart JR | 2001 | Cancer Metastasis Rev2001，20，12： | 1 |
| 19 | Effect of manni-tol and furosemide on plasma osmolality and brain water显示文摘 | Thenuwara K Todd M M Brian J E Jr | 2002 | Anesthesiology2002，96，2： | 1 |
| 20 | Prospects for targeting protein kinase C isozymes in the therapy of drug-resistant cancerAn evolving story 显示文摘 | Ward NE Stewart JR | 2001 | Cancer Metastasis Rev2001，20，12： | 1 |
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