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| 1 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 2 | Bradford's law and the Bibliography of Science显示文摘 | Brockes B C | 1969 | Nature1969，224，： | 1 |
| 3 | Feasibility of a novel deformable image registration technique to facilitate elassifieation, targeting, and monitoring of tumor and normal tissue 显示文摘 | Brock K K Dawson L A Sharpe M B | 2006 | Int J Radiat Oneol Biol Phys2006，64，4： | 1 |
| 4 | Comparative proteomic analysis of matched primary and metastatic melanoma cell lines显示文摘 | AL-GHOUL M BROCK T B LAUER-FIELDS J L | 2008 | J Proteome Res2008，7，9： | 1 |
| 5 | Alzheimer's disease(AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead(Pb):evidence for a developmental origin and environmental link for AD显示文摘 | Wu J Basha MR Brock B | 2008 | J Neurosci2008，28，1： | 1 |
| 6 | Liraglutide, a once- daily human GLP-1 analogue,improves pancreatic B-cell function and arginine-slimulated insulin in patients with Type 2 diabetes secretion during hyperglycaemia mellitas显示文摘 | VILSBLL T BROCK B PERRILD H | 2008 | Diabet Med2008，25，2： | 1 |
| 7 | Measurement and parameterization of albedo variations at Haut Glacier d'Arolla, Switzerland显示文摘 | Brock B W Willis I C Sharp M J | 2000 | 46(155) : 675-6882000，46，155： | 1 |
| 8 | Bradford's law and the Bibliography of Science 显示文摘 | Brockes B C | 1969 | Nature1969，224，： | 1 |
| 9 | Effect of thermal annealing on the optical and morphological properties of (AETH) PbX4 ( X = Br, I) perovskite films prepared using single source thermal ablation 显示文摘 | Konstantinos Chondroudis David B Mitzi Phillip Brock | 2000 | Chem Mater2000，12，： | 1 |
| 10 | Anakinra: a safe and effective first-line treatment in systemic onset juvenile idiopathic arthritis (SoJIA) 显示文摘 | Hedrich CM Brock N Fiebig B | 2012 | Rheumatol Int2012，32，11： | 1 |
| 11 | Relationship between Fish Communities and Remotely Sensed Measurements in Bis- cayne National Park, Florida, USA显示文摘 | Kuffner I B Brock J C Grober D R | 2007 | Environmental Biology of Fishes2007，78，1： | 1 |
| 12 | Experimental obervations of a left-handed material that obeys Snell's law 显示文摘 | HOUCK A A BROCK J B CHUANG I L | 2003 | Physical Review Letters2003，90，13： | 1 |
| 13 | Inflammatory cytokines pul- monary hypertension显示文摘 | Groth A Vruqt B Brock M | 2014 | Respir Res2014，15，： | 1 |
| 14 | Experience with building a commodity Intel-based eeNUMA system 显示文摘 | Brock B C Carpenter G D Chiprout E | 2001 | IBM J RES & DEV2001，45，2： | 1 |
| 15 | Measurement of soil microbial biomass provides an early indication of changes in total organic matter due to straw incorporation 显示文摘 | Powlson D S Brockes P C Christensen B T | 1987 | Soil Biology &Biochemistry1987，19，： | 1 |
| 16 | A test for independence based on the correlation dimension显示文摘 | Dechert D Scheinkman B | 1996 | Econometric Reviews1996，15，： | 1 |
| 17 | Biodegradation of crystal violet by the white roffungus Phanerochaete chrysosporium显示文摘 | BUMPUS J A BROCK B J | 1988 | Appl Environ Microbiol1988，54，5： | 1 |
| 18 | Partially covered self - expand- able metallic stents for benign biliary strictures due to chronic pan- creatitis显示文摘 | Behm B Brock A Clarke B W | 2009 | Endoscopy2009，41，6： | 1 |
| 19 | Uric acid a risk factor for coronary heartdisease 显示文摘 | Huntley J C Brock D B Osffeld H M | 1993 | JAMA1993，，270： | 1 |
| 20 | Biodegradation of crystal violet by the whiterot fungus Phanerochaete ehrysosporium 显示文摘 | BUMPUS J A BROCK B J | 1988 | Appl Environ Microh1988，54，5： | 1 |
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