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| 1 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 2 | Treatment of ARDS显示文摘 | Brower RG Ware LB Berthiaume Y | 2001 | Chest2001，120，4： | 1 |
| 3 | Medical education and information literacy in the era of open access显示文摘 | Brower SM | 2010 | Med Ref Serv Q2010，29，1： | 1 |
| 4 | Defective intracellular Ca2+ homeostasis contributes to myocyte dysfunction during ventricular remodelling induced by chronic volume overload in rats 显示文摘 | Ding Y F Brower G L Zhong Q | 2008 | Clin Exp Pharmacol Physiol2008，35，7： | 1 |
| 5 | Flexible transbronchial needle aspiration for staging of bronehogenic carcinoma显示文摘 | Wang KP Brower R Haponik EF | 1983 | Chest1983，84，5： | 1 |
| 6 | Evolutionarily conserved mammalian ade- nine nueleotide translocase 4 is essential for spermatogenesis显示文摘 | Brower JV Rodic N Seki T | 2007 | J Biol Chem2007，282，29： | 1 |
| 7 | Higher versus lower positive end-expiratOry pressures in patiellts with the a- cute respiratory distress syndrome 显示文摘 | Brower RG Lanken PN Maclntyre N | 2004 | N Engl J Med2004，351，4： | 1 |
| 8 | Vector-borne diseases and global warming: are both on an upward swing? Scientists are still debating whether global warming will lead to a further spread of mosquitoes and the diseases they transmit显示文摘 | Brower V | 2001 | EMBO Rep2001，2，9： | 1 |
| 9 | Factors associated with elevated plateau pressure in patients with acute lung injury receiving lower tidal volume ventilation 显示文摘 | Prescott HC Brower RG Cooke CR | 2013 | Crit Care Med2013，41，3： | 1 |
| 10 | Lung-protective ventilation strategies m acute lung injury显示文摘 | Brower R G Rubenteld G D | 2003 | Crit Care Med2003，31，： | 1 |
| 11 | Coronary artery atherosclerosis:severity of the disease,severity of angina pectoris and compromised left ventricular function显示文摘 | DM Leaman RW Brower GT Meester | 1981 | Circu- lation1981，63，： | 1 |
| 12 | Treatment of ARDS显示文摘 | Brower R G Ware L B Berthiaume Y | 2001 | Chest2001，120，： | 1 |
| 13 | Higher versus lower positive end - expiratory pressures in patients with the acute respirato- ry distress syndrome显示文摘 | Brower RG Lanken PN Maclntyre N | 2004 | N EnglJ Med2004，351，4： | 1 |
| 14 | Regulation of matrix metalloproteinases is at the heart of myocardial remodeling显示文摘 | Levick SP Brower GL | 2008 | Am J Physiol Heart Circ Physiol2008，295，4： | 1 |
| 15 | The synthesis of (4R-cis) -1, 1 -dimethylethyl, 6-cyanomethyl-2,2-dimethyl-1, 3-dioxane4-acetate, a key intermediate for the preparation of CI- 981, a highly potent, tissue selective inhibitor of HMG-CoA re- ductase 显示文摘 | BROWER PL BUTLER DE DEERING CF | 1992 | Tetrahedron Lett1992，33，17： | 1 |
| 16 | Commercialization of collegorm-an industrialist's view 显示文摘 | Browers R C | 1986 | Weed Science1986，34，： | 1 |
| 17 | Intra-andinterspecific mitochondrial DNA sequence variation within two species of rock-dwelling Cichlids(Teleostei : Cichlidae) fromLake Malawi ,Africa显示文摘 | BROWERS N STAUFFER J R KOCHERT D | 1994 | Molecular Phylogenetics and Evolution1994，3，4： | 1 |
| 18 | Long- term follow- up in newborn screening: a systems approach for improving health outcomes显示文摘 | Lloyd- Puryear MA Brower A | 2010 | Genet Med2010，12，12： | 1 |
| 19 | Flexible transbronchial needle aspiration for staging of bronchogenic carcinoma 显示文摘 | Wang KP Brower R Haponik EF | 1983 | Chest1983，84，： | 1 |
| 20 | Effects of Positive end-expiratory pressure on the canine venous return curve 显示文摘 | FESSLER H E BROWER R G WISE R A | 2003 | Am Rev Respir Dis2003，146，1： | 1 |
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