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1Significant decrease in prevalence ofHelicobacter pylori in the Czech Republic显示文摘AIM:To study possible decrease in prevalence of Helicobacter pylori(H.pylori) infection in the Czech Republic within a 10-year period.METHODS:A total of 22 centres entered the study.The catchment areas of these centres covered cities and towns with more than 20 000 inhabitants,smaller towns(≤ 20 000 inhabitants) with surrounding villages and rural areas,and were spread over the whole country,corresponding well to the geographical distribution of the Czech population.A total of 1 837 subjects(aged 5-98 years) took part in the study,randomly selected out of 38 147 people from the general population.H.pylori infection was investigated by means of a 13 C-urea breath test.Breath samples in duplicates were analysed using isotope ratio mass spectrometry.The cut-off point was 3.5.Social and demographic characteristics were based on data from self-completed questionnaires.RESULTS:The overall prevalence of H.pylori infection was 23.5%(430/1826),and 4.8%(20/420) in children aged 15 or less.There was no statistically significant difference in prevalence between males(24.3%;208/857) and females(22.9%,222/969,P = 0.494).H.pylori infection was strongly associated with higher age,among subjects aged 55+ years,prevalence of H.pylori infection was 39.8%(252/633,P < 0.001).The highest prevalence of H.pylori infection was found among persons aged 55-64 years(43.9%,97/221) and 75+ years(37.9%,58/153).Among study subjects aged 15+ years,prevalence of H.pylori infection was significantly increased in those with lowest education(odds risk 3.19,95% CI 1.87-5.47).Compared to never married(14.1%),the prevalence of H.pylori infection was statistically significantly higher among married(35.4%,246/694,P < 0.001),divorced(36.8%,49/133,P < 0.001) and widowed study subjects(40.2%,45/112,P < 0.001),both in minimally and fully adjusted analysis.There was no significant difference in the prevalence of H.pylori infection between married and widowed subjects(35.4%,246/694 vs 40.2%,45/112,P = 0.389).There was little variation in smoking prevalence across categories of smoking and there was no evidence of an increased risk ofH.pylori infection among current or past smokers in our data(odds risk 1.04 with 95% CI 0.78-1.40 for current smokers;odds ratio 0.83 with 95% CI 0.60-1.16 for former smokers).The current prevalence of H.pylori in 2011 was significantly lower compared to the prevalence reported from identical geographical areas in 2001(23.5%vs 41.7%,P < 0.001).CONCLUSION:The overall prevalence of H.pylori infection in the general population has fallen substantially in the Czech Republic over the past 10 years.Jan Bure Marcela Kopáová Ilona Koupil Bohumil Seifert Miluka kodová Fendrichová Jana pirková Viktor Voíek Stanislav Rejchrt TomáDouda Norbert Král Ilja Tachecí 2012World Journal of Gastroenterology2012,18,32:8
2Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events 显示文摘Richer PM Riled N Rose L Buring JE Cook NR 2002N Engl J Med2002,347,20:1
3Generating i PSCs:translating cell reprogramming science into scalable and robust biomanufacturing strategies显示文摘Silva M Daheron L Hurley H Bure K Barker R Carr AJ 2015Cell Stem Cell2015,16,1:1
4Alcohol consumption and risk of calxliovascular disease and death in women: potential mediating mechanisms 显示文摘Djouss6 L Lee IM Buring JE 2009Circulation2009,120,3:1
5A prospective study of consumption of carotenoids in fruits and vegetables and decreased cardiovascular mortality in elderly 显示文摘Gaziano J Manson J Brance L Colditz G Willet W Buring J 1995Annals of Epidemiology1995,5,4:1
6The Effect of Etching on Low-Mechanical Polypropylene Fabrics under Helium/Oxygen Atmospheric Pressure Plasum 显示文摘Qiu Y Zhang C Hwang Y J Bures B L etal 2003Adhesion Sci Techno12003,12,24:1
7Comparison of interleukin - 6 and e - reaeteve protein for the risk of developing hypertension in women显示文摘Sesso HD Wang L Buring JE 2007Hypertension2007,49,3:1
8Stabilizing selection on genome size in a population of Festuca pallens under conditions of intensive intraspecific competition 显示文摘SARDA P HOROVAt L BURES P 2010New Phytologist2010,187,4:1
9Pigs are not a reliable experimental model in the study of the haemodynamic and respiratory effects of CO2 pneumoperitoneum显示文摘Richard L Bures E Lacoste L 2002Acta Anaesthesiol Scand2002,46,1:1
10prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women显示文摘 Buring JE Shih L 1998Circulation1998,98,:1
11Comparison of interleukin-6 and C-reactive protein for the risk of developing hypertension in women 显示文摘Sesso HD Wang L Buring JE 2007Hypertension2007,49,2:1
12Comparison of meat quality between eland ( Taurotragus oryx) and cattle ( Bos taurus ) raised under similar conditions 显示文摘Bartofi L Bure D Kotrba R 2014Meat Science2014,96,1:1
13Mode of action of a novel nonchemical method of insect control:atmospheric pressure plasma discharge显示文摘Donohue K V Bures B L Bourham M A 2006J Econ Entomol2006,99,1:1
14Comparison of meat quality between eland (Taurotragus oryx) and cattle (Bos taurus) raised under similar conditions显示文摘BARTOIq L BURE D KOTRBA R 2013Meat Science2013,96,1:1
15The polymorphisms of stearoyl-CoA desaturase ( SCD1 ) and sterol regulatory ele- ment binding protein-1 ( SREBP-1 ) genes and their associa- tion with the fatty acid profile of muscle and subcutaneous fat in Fleckvieh bulls 显示文摘Barton L Kott T Bures D 2010Meat Sci2010,85,1:1
16Comparison of interleukin 6 and C-reactive protein for the risk of devel- oping hypertension in women显示文摘Sesso HD Wang L Buring JE 2007Hypertension2007,49,2:1
17Comparison ofinterleukin-6 and C-reactive protein for the risk of developing hypertension in women显示文摘Sesso HD Wang L Buring JE 2007Am J Hypertension2007,49,2:1
18Dietary intake of dairy products, Calcium, and vitamin D and the risk of hypertension in middle-aged and older women显示文摘Wang L Manson JE Buring JE 2008Hypertension2008,51,4:1
19Comparison of interleukin-6 and C-reactive protein for the risk of developing hypertension in women显示文摘Sesso H D Wang L Buring J E 2007Am J Hypertension2007,49,2:1
20Indel patterns of the plastid DNA trnL-trnF region within the genus Poa (Poaceae) 显示文摘Stoneberg Holt S D Horova L Bures P 2004Journal of Plant Research2004,117,5:1
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