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| 1 | Appropriateness of outpatient gastrointestinal endoscopy in a non-academic hospital显示文摘AIM:To assess the appropriate use and the diagnostic yield of upper gastrointestinal endoscopy and colonoscopy in this subgroup of patients.METHODS:In total,789 consecutive outpatients referred for gastrointestinal(GI) endoscopy [381 for esophagogastroduodenoscopy(EGD) and 408 for colonoscopy] were prospectively enrolled in the study.The American Society for Gastrointestinal Endoscopy(ASGE) guidelines were used to assess the relationship between appropriateness and the presence of relevant endoscopic f indings.RESULTS:The overall inappropriate rate was 13.3%.The indications for EGD and colonoscopy were,respectively,appropriate in 82.7% and 82.6% of the exams,uncertain in 5.8% and 2.4% and inappropriate in 11.5% and 15%.The diagnostic yield was signif icant higher forEGDs and colonoscopies judged appropriate and uncertain when compared with those considered inappropriate(EGD:36.6% vs 36.4% vs 11.4%,P = 0.004;Colonoscopy:24.3% vs 20.0% vs 3.3%,P = 0.001).Of the 25 malignant lesions detected,all but one was detected in exams judged appropriate or uncertain.CONCLUSION:This study shows a good adherence to ASGE guidelines by the referring physicians and a significant increase of the diagnostic yield in appropriate examinations,namely in detecting neoplastic lesions.It underscores the importance that the appropriateness of the indication assumes in assuring high-quality GI endoscopic procedures. | Joo Mangualde Marie I Cremers Ana M Vieira Ricardo Freire lia Gamito Cristina Lobato Ana L Alves Fátima Augusto Ana P Oliveira | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，10： | 2 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 4 | The Toxoplasma gondii bradyzoite antigens BAG1 and MAG1 induce early humoral and cell-mediated immune responses upon human infection 显示文摘 | Di Cristina M Del Porto P Buffolano W | 2004 | Microbes Infect2004，6，2： | 1 |
| 5 | Pemetrexed im-proves tumor selectivity of 111In-DTPA-Folate in micewith folate receptor-positive ovarian cancer显示文摘 | Cristina M Roger S Eric P | 2008 | J NuclMed2008，49，： | 1 |
| 6 | Workplace violence: a known phenomenon in Barcelona nursing homes显示文摘 | CRISTINA Vidal M CARLES P T | 2014 | Galley Proof2014，24，3： | 1 |
| 7 | New targets for Ph+ leukaemia therapy显示文摘 | Giovanni M Ilaria I Cristina P | 2009 | Best Pract Res Clin Haematol2009，22，3： | 1 |
| 8 | Solid-phase mieroex trac- tion and gas chromatography olfactometry analysis of succes- sively diluted samples: A new approach of the aroma extract di- lution analysis applied to the char acterization of wine aroma 显示文摘 | Maria P M Montserrat M Cristina S | 2003 | J Agric Food Chem2003，51，： | 1 |
| 9 | Remodeling in Response to infection and Injury显示文摘 | Maestrelli P Saetta M Cristina E | | 0，，： | 1 |
| 10 | Capacity of a horizontal subsurface flow constructed wetland system for the removal of emerging pollutants:An injection experiment显示文摘 | Cristina A Anna P Victor M | 2010 | Chemosphere2010，81，9： | 1 |
| 11 | Phosphorus deficiency and kinetics of alkaline phosphatase in isolates and natural populations of phototrophic sulphur bacteria 显示文摘 | BAKIERAS L ROS-PONSATI M CRISTINA X P | 2010 | Microbiology Ecology2010，73，： | 1 |
| 12 | New therapeutic perspectives in HBV : when to stop NA s显示文摘 | Cristina Pérez‐Cameo Mònica Pons Rafael Esteban | 2014 | Liver Int2014，，： | 1 |
| 13 | Sleep-disordered breathing in nonobese diabetic subjects with autonomic neuropathy 显示文摘 | Bottini P Dottorini ML Cristina M | 2003 | Eur Respir J2003，22，4： | 1 |
| 14 | Fire models and methods to map fu- el types:the role of Remote Sensing 显示文摘 | Lara A A Cristina P Jose A M | 2008 | Forest Ecology and Man- agement2008，256，： | 1 |
| 15 | Mammaglobin Expression in Leukapheresis Products Is a Predictive Marker of Poor Prognosis in Women with High-Risk Breast Cancer显示文摘 | Pier P F Cristina R Chiara M | 2004 | Clinical Cancer Research2004，18，1： | 1 |
| 16 | Nonlinear Boundary Conditions for Elliptic Equations 显示文摘 | AMSTER P CRISTINA M MENDEZ O | 2005 | Electron J Differ- ential Equations2005，144，： | 1 |
| 17 | Application of predictive sliding mode controllers to a solar plant 显示文摘 | Mercedes P P Cristina M C Eduardo F C | 2008 | IEEE Transactions on Control System Technology2008，16，4： | 1 |
| 18 | Perioperative CA19 -9 levels can predict stage and survival in patients with resectable pancreatic adeocarcinoma 显示文摘 | Cristina R Ferrone Dianne M Finkelstein Sarah P Thayer | 2006 | Clinical Oncology2006，24，6： | 1 |
| 19 | Reducing the time of sperm-oocyte interaction in human in-vitro fertilization improves the improves the implantation rate显示文摘 | Gianaroli L Cristina Magli M Ferraretti A P | 1996 | Hum Reprod1996，11，1： | 1 |
| 20 | Specific-based im-munoassays for sulfathiazole显示文摘 | Nuria P N Cristina G B Angel M | | 0，，12： | 1 |
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