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| 1 | Prophylaxis with ketotifen in rats with portal hypertension:involvement of mast cell and eicosanoids显示文摘BACKGROUND:Since we have previously shown an increase of mast cells in the small bowel and in the mesenteric lymph nodes in the rats with prehepatic portal hypertension,it can be hypothesized that this essential inflammatory cell would be involved in the pathogeny of the splanchnic changes related to portal hypertension. METHODS:To verify this hypothesis,we first studied mast cell infiltration in the ileum and in the mesenteric lymph nodes in sham-operated male Wistar rats(n=12) and in short-term prehepatic portal hypertensive rats (n=12),and the serum levels of rat mast cell protease Ⅱ(RMCP-Ⅱ)by ELISA.In a second set of experiments ketotifen,a mast cell stabilizer drug,was administered to sham-operated(n=10)and portal hypertensive(n=12) rats 24 hours before the intervention and prostanoids (PGE2,PGI2,TXB2)and leukotrienes(LTC4,LTB4)were assayed by RIA,mast cell infiltration in the ileum and in the mesenteric lymph nodes and the serum levels of RMCP-Ⅱwere also studied,to show its effectiveness to prevent the mesenteric alterations produced by the inflammatory mediators released by the mast cell. RESULTS:Forty-eight hours after the intervention RMCP-Ⅱ (P<0.05),PGE2(P<0.001)and LTC4 serum levels decreased and mast cell number and RMCP-Ⅱlevels increased in mesenteric lymph nodes in portal hypertensive rats.Prophylactic administration of ketotifen reduced portal pressure(P<0.001),serum levels of PGE2(P<0.001)and RMCP-Ⅱ(P<0.001)in mesenteric lymph nodes. CONCLUSIONS:In acute portal hypertension in the rat,the mast cell translocation from intestinal mucosa to mesenteric lymph nodes,where they are activated and degranulates,would represent a defence mechanism to avoid the activation of an acute and massive inflammatory response in this location.Prophylactic administration of ketotifen is able to reduce the splanchnic inflammatory changes related to acute portal hypertension in the rat. | Fernando Sánchez-Patán Raquel Anchuelo Elena Vara Cruz García Yolanoa Saavedra Patri Vergara Carmen Cuellar Marta Rodero Maria-Angeles Aller Jaime Arias | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 2 |
| 2 | Sweetpotato viruses: 15 years of progress on understanding and managing complex diseases显示文摘 | Clark C A Davis J A Abad J A Cuellar W J Fuentes S Kreuze J F Gibson R W Mukasa S Tugume A K Tairo F Valkonen J P T | 2012 | Plant Disease2012，96，2： | 1 |
| 3 | III cranial nerve palsy mad brainstem disfunction following retro- bulbar anaesthesia显示文摘 | Armada Calleja MA Martinez Pueyo A Bellido Cuellar S | 2011 | Neurologia2011，26，9： | 1 |
| 4 | Duration of grain filling and kernel weight of wheat as effected by temperature 显示文摘 | Wiegand C L Cuellar J A | 1981 | Crop Sci1981，21，1： | 1 |
| 5 | Duration of grain filling and kernel weight of wheat as affected by temperature 显示文摘 | Wiegand C L Cuellar J A | 1981 | Crop Science1981，21，： | 1 |
| 6 | Evolution of the Mexican Seismic Alert System (SASMEX)显示文摘 | Espinosa-Aranda J M Cuellar A Garcia A | 2009 | Smsmol Res Lett2009，80，： | 1 |
| 7 | Dicer! and miR-219 Are required for normal oligodendrocyte differentiation and myelination显示文摘 | Dugas JC Cuellar TL Scholze A | 2010 | Neuron2010，65，5： | 1 |
| 8 | Dicerl and miR- 219 are required for normal oligodendroeyte differentia- tion and myelination显示文摘 | Dugas JC Cuellar TL Scholze A | 2010 | Neuron2010，65，5： | 1 |
| 9 | Evolution of the Mexican Seismic Alert System (SASMEX) 显示文摘 | Espinosa-Aranda J M Cuellar A Garcia A | 2009 | Seismological Research Letters2009，80，5： | 1 |
| 10 | Spatial variation of redox and trace metal geo- chemistry in a minerotrophic fen 显示文摘 | Koretsky C M Haveman M Beuving L Cuellar A Shattuck T Wagner M | 2007 | Biogeochemistry2007，86，1： | 1 |
| 11 | Accelerated degeneration after failed cervical and lumbar nucleoplasty显示文摘 | CUELLAR V G CUELLAR J M VACCARO A R | 2010 | J Spinal Disord Tech2010，23，8： | 1 |
| 12 | Increased CD4^+/ CD8^+ double-positive T cells in chronic Chagasic patients显示文摘 | Giraldo NA Bolanos NI Cuellar A | 2011 | PLoS Neglect Trop D2011，5，8： | 1 |
| 13 | Vegetation density as deduced from ERTS21 MSS response显示文摘 | Wiegand C L Gausman H W Cuellar J A | 1974 | Third ETRS Symp NASA2SP23511974，，1： | 1 |
| 14 | Prolactin Induces Autoantibody Formation by PBL of Normal Individuals and SLE Patients显示文摘 | GUTIERREZ M A CABRERA C E CUELLAR M L | 1993 | Arthritis Rheum1993，36，2： | 1 |
| 15 | Residual stress and fatigue life in laser shock peened open hole samples 显示文摘 | CUELLAR S D HILL M R DEWALD A T | 2012 | International Journal of Fatigue2012，，44： | 1 |
| 16 | Duration of grain filling and kernel weight of wheat as effected by temperature显示文摘 | Wiegand C L Cuellar J A | 1981 | Crop Sei1981，21，1： | 1 |
| 17 | Dy- namics of Haemophilus parasuis genotypes in a farm recovered from an outbreak of Glasser's disease 显示文摘 | OLVERA A CERDA -CUELLAR M NOFRARfAS M | 2007 | Vet Microbial2007，123，123： | 1 |
| 18 | Scalable RFID systems: a privacy-preserving protocol with constant-time identification 显示文摘 | Alomair B Clark A Cuellar J | 2012 | IEEE Transactions on Parallel and Distributed Systems2012，23，8： | 1 |
| 19 | Duration of grain filling mad kernel weight of wheat as affected by temperature显示文摘 | Wiegand C L Cuellar J A | 1981 | Crop Sci1981，21，： | 1 |
| 20 | Residual stressand fatigue life in laser shock peened open hole samples显示文摘 | Cuellar S D H ill M R DeWald A T | 2012 | International Journal of Fatigue2012，44，： | 1 |
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