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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | New era of colorectal cancer screening显示文摘Colorectal cancer(CRC) is the 2^(nd) most common cancer in women and 3^(rd) most common cancer in men worldwide. Most CRCs develop from adenomatous polyps arising from glandular epithelium. Tumor growth is initiated by mutation of the tumor suppressor gene APC and involves other genetic mutations in a stepwise process over years. Both hereditary and environmental factors contribute to the development of CRC. Screening has been proven to reduce the incidence of CRC. Screening has also contributed to the decrease in CRC mortality in the United States. However,CRC incidence and/or mortality remain on the rise in some parts of the world(Eastern Europe,Asia,and South America),likely due to factors including westernized diet,lifestyle,and lack of healthcare infrastructure. Multiple screening options are available,ranging from direct radiologic or endoscopic visualization tests that primarily detect premalignant or malignant lesions such as flexible sigmoidoscopy,optical colonoscopy,colon capsule endoscopy,computed tomographic colonography,and double contrast barium enema- to stool based tests which primarily detect cancers,including fecal DNA,fecal immunochemical test,and fecal occult blood test. The availability of some of these tests is limited to areas with high economic resources. This article will discuss CRC epidemiology,pathogenesis,risk factors,and screening modalities with a particular focus on new technologies. | Maysaa El Zoghbi Linda C Cummings | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，5： | 7 |
| 3 | TYPE OF FALL AND RISK OF HIP AND WRIST FRACTURES-THE STUDY OF OSTEOPOROTIC FRACTURES显示文摘 | Nevitt M C Cummings S R Black D | 1993 | JOURNAL OF THE AMERICAN GERIATRICS SOCIETY1993，41，11： | 1 |
| 4 | Does anovulation exist in eumenorrheic women显示文摘 | MALCOLM C E CUMMING D C | 2003 | Obstet Gynecol2003，102，： | 1 |
| 5 | Calculation of viscous EHL traction for squalane using molecular simulation and rheometry显示文摘 | Bair S McCabe C Cummings P T | 2002 | Tribology Letters2002，13，4： | 1 |
| 6 | Comparison of C++ and Fortran 90 for object-oriented scientific programming显示文摘 | Cary J R Shasharina S G Cummings J C | 1997 | Computer Physics Communications1997，105，： | 1 |
| 7 | Effect of dexamethasone on the duration of interscalene nerve blocks with ropivacaine or bupivacaine显示文摘 | Cummings K C Napierkowsk D E Parra-Sanchez | 2011 | British Journal of Anaesthesia2011，107，： | 1 |
| 8 | Size-fractionated nitrogen uptake and carbon fixation during a developing coccolithophore bloom in the North Sea during June 1999显示文摘 | Malcolm E Woodward S Robinson C Cummings D G Tarran G A Joint Ⅰ | 2002 | Deep-Sea Research Ⅱ2002，49，15： | 1 |
| 9 | Trinucleotide repeats: mechanisms and pathophysiology显示文摘 | Cummings C J Zoghbi H Y | 2000 | Annual Review of Genomics and Human Genetics2000，1，： | 1 |
| 10 | Reassessing the principles of electrical stimulation 显示文摘 | Simmons N J Daly C C Cummings T L | 2008 | Meat Science2008，80，： | 1 |
| 11 | Lymphomas and high-grade astrocytomas: comparison of water dif- fusibility and histologic characteristics 显示文摘 | Guo A C Cummings T J Dash R C | 2002 | Radiology2002，224，1： | 1 |
| 12 | Lymphomas and high gradeastrocytomas:comparison of water diffusibility and histologic char-acteristics显示文摘 | Guo A C Cumming T J Dash R C | 2002 | Radiology2002，224，1： | 1 |
| 13 | Association between Alzheimer's disease and the NOS3 gene 显示文摘 | Dahiyat M Cumming A Harrington C | 1999 | Ann Neurol1999，46，4： | 1 |
| 14 | The sleep disorders invcnroty an instrument for studiees of sleep disturbancc in persons with Alzheimets disease 显示文摘 | TRACTEN BENG R E SINGER C M CUMMINGS J L | 2003 | J Sleep Res2003，12，4： | 1 |
| 15 | Migrating luteinizing hormone-releasing hormone (LHRH) neurons and processes are associated with a substrate that expresses S100显示文摘 | Brunjes P C | 1995 | Brain Res Dev Brain Res1995，88，： | 1 |
| 16 | DNA sequence variation in the ribosomal internal transcribed spacer region of freshwater Cladophora species (Chlorophyta) 显示文摘 | Marks J C Cummings M P | 1996 | Journal of Phycology1996，32，： | 1 |
| 17 | Adenocarcinoma of the rectum treated with radical external radiation therapy 显示文摘 | Brierley J D Cummings B J Wong C S | 1995 | Int J Radiat Oncol Biolphys1995，31，2： | 1 |
| 18 | Children's representations of multiple family relationships:Organizational structure and development in early childhood显示文摘 | Schermerhorn A C Cummings E M Davies P T | 2008 | J Fam Psychol2008，22，1： | 1 |
| 19 | Kawasaki disease associated with ractive hemophagocytic lymphohistiocytosis显示文摘 | Cummings C McCarthy P van Hoff L | 2008 | Pediatr Infect Dis J2008，27，12： | 1 |
| 20 | Adult paratestieular sarcomas: a review of 21 cases 显示文摘 | Carton C N Cummings B J Fornasier V | 1991 | J Urol1991，146，2： | 1 |
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