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| 1 | Trend analysis of cancer incidence and mortality in China显示文摘The National Central Cancer Registry of China(NCCRC)updated their nationwide statistics of cancer incidence and mortality in China according to 2013 population-based cancer registration data(due to the time required for data collection,quality control and analysis,the latest cancer statistics available in China have a 3-year lag behind the current year).In this report,the NCCRC provides a comprehensive review of cancer incidence and mortality rates,as well as the statistics overall and by geographical area,cancer sites or age groups(Chen et al.,2017a).It shows that the burden of cancer | Fang Wei Yingfen Wu Le Tang Fang Xiong Can Guo Xiayu Li Ming Zhou Bo Xiang Xiaoling Li Guiyuan Li Wei Xiong Zhaoyang Zeng | 2017 | Science China(Life Sciences)2017，60，11： | 16 |
| 2 | Analysis of Chinese women with primary ovarian insufficiency by high resolution array-comparative genomic hybridization显示文摘背景主要卵巢的不足(夏威夷人用芋头做成的食品) 被定义为不在的月经初潮(主要停经) 或卵巢的滤泡的早熟的弄空在 40 年的年龄前描绘的一个主要卵巢的缺点。在人的女病人的主要卵巢的不足的病原学仍然是不清楚的。这研究的目的是调查在由高分辨率的主要停经病人的基因原因穿基于的比较 genomic 杂交( array-CGH ) analysis.Methods 列在后面的潜力标准 karyotyping 分析,从 15 个主要停经病人和 15 个正常控制女人的整个血的 genomic DNA 是有跟随标准协议的 Affymetrix 细胞发生的 2.7M 数组的 hybridized 。array-CGH 识别的拷贝数字变化都被实时聚合酶链 reaction.Results 证实 30 件样品由常规 karyotyping 分析是否定的。有约 1.3 Mb 的染色体 17q21.31-q21.32 上的 Microdeletions 被高分辨率 array-CGH 分析在四个病人识别。这包括了女繁殖能分泌的小径礼品的结果学习的相关因素 N-ethylmaleimide-sensitive 因素(NSF ) gene.Conclusions 建议可以有批评区域,与 17q21.31-q21.32 microdeletion 在女人调整主要卵巢的不足。这效果可能由于在删除的区域以内或到连续基因上的效果的 NSF 基因 / 基因的功能的损失。 | LIAO Can FU Fang YANG Xin SUN Yi-min LI Dong-zhi | 2011 | Chinese Medical Journal2011，，11： | 9 |
| 3 | Atorvastatin protects cardiac progenitor cells from hypoxia-induced cell growth inhibition via MEG3/miR-22/HMGB1 pathway显示文摘Heart failure (HF)induced by ischemia myocardial infarction (MI)is one of the major causes of morbidity and mortality all around the world.Atorvastatin,a hydroxyrnethylglutaryl coenzyme A reductase inhibitor,has been demonstrated to benefit patients with ischemic or non-ischemicinduced HF,but the mechanism is still poorly understood.Increasing evidence indicates that IncRNAs play important role in variety of human disease.However,the role and underlying molecular mechanisms remain largely unclear.In our work,we applied 0.5%02 to generate a hypoxia cardiac progenitor cell (CPC)model.Then,CCK8 and EdU assays were employed to investigate the role of atorvastatin in hypoxia CPC cell model.We found that hypoxia inhibits CPC viability and proliferation through modulating MEG3 expression,while atorvastatin application can protect CPCs from hypoxia-induced injury through inhibiting MEG3 expression.Then,we demonstrated that repression of MEG3 inhibited the hypoxia-induced injury of CPCs and overexpression of MEG3 inhibited the protective effect of atorvastatin in the hypoxia-induced injury of CPCs.Furthermore,our study illustrated that atorvastatin played its role in CPC viability and proliferation by modulating the expression of HMGB1 through the MEG3/miR-22 pathway.Our study, for the first time,uncovered the molecular mechanism of atorvastatin's protective role in cardiomyocytes under hypoxia condition,which may provide an exploitable target in developing effective therapy drugs for MI patients. | Jinwen Su Ming Fang Bei Tian Jun Luo Can Jin Xuejun Wang Zhongping Ning Xinming Li | 2018 | Acta Biochimica et Biophysica Sinica2018，50，12： | 6 |
| 4 | A Pilot Study of Quantitative Loop-mediated Isothermal Amplification-guided Target Therapies for Hospital-acquired Pneumonia显示文摘 | Fang Wang Ran Li Ying Shang Can Wang Guo-Qing Wang DeXun Zhou Dong-Hong Yang Wen Xi Ke-QiangWang Jing Bao Yu Kang Zhan-Cheng Gao | 2016 | Chinese Medical Journal2016，，2： | 5 |
| 5 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 6 | Omics-based integrated analysis identified ATRX as a biomarker associated with glioma diagnosis and prognosis显示文摘Objective:ATRX is a multifunctional protein that is tightly regulated by and implicated in transcriptional regulation and chromatin remodeling.Numerous studies have shown that genetic alterations in ATRX play a significant role in gliomas.This study aims to further determine the relationship between ATRX and glioma prognosis and identify possible mechanisms for exploring the biological significance of ATRX using large data sets.Methods:We used The Cancer Genome Atlas(TCGA)database and 130 immunohistochemical results to confirm the difference in ATRX mutations in high-and low-grade gliomas.An online analysis of the TCGA glioma datasets using the cBioPortal platform was performed to study the relationship between ATRX mutations and IDH1,TP53,CDKN2 A and CDKN2 B mutations in the corresponding TCGA glioma dataset.In combination with clinical pathology data,the biological significance of the relationships were analyzed.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analyses and annotations of all adjacent genes in the network were performedin the Database for Annotation,Visualization and Integrated Discovery(DAVID)and R language.A protein-protein interaction(PPI)network was constructed,and the interactions of all adjacent nodes were analyzed by the String database and using Cytoscape software.Results:In the selected TCGA glioma datasets,a total of 2,228 patients were queried,21%of whom had ATRX alterations,which co-occurred frequently with TP53 and IDH1 mutations.ATRX alterations are associated with multiple critical molecular events,which results in a significantly improved overall survival(OS)rate.In low-grade gliomas,ATRX mutations are significantly associated with multiple important molecular events,such as ZNF274 and FDXR at mRNA and protein levels.A functional cluster analysis revealed that these genes played a role in chromatin binding and P53,and a link was observed between ATRX and IDH1 and TP53 in the interaction network.ATRX and TP53 are important nodes in the network and have potential links with the blood oxygen imbalance.Conclusions:ATRX mutations have clinical implications for the molecular diagnosis of gliomas and can provide diagnostic and prognostic information for gliomas.ATRX is expected to serve as a new therapeutic target. | Yingbin Xie Yanli Tan Chao Yang Xuehao Zhang Can Xu Xiaoxia Qiao Jianglong Xu Shaohui Tian Chuan Fang Chunsheng Kang | 2019 | Cancer Biology & Medicine2019，16，4： | 5 |
| 7 | Facile Self-templating Melting Route Preparation of Biomass-derived Hierarchical Porous Carbon for Advanced Supercapacitors显示文摘 | WANG Can WANG Dianyu ZHENG Shuang FANG Xueqing ZHANG Wenli TIAN Ye LIN Haibo LU Haiyan JIANG Lei | 2018 | Chemical Research in Chinese Universities2018，34，6： | 5 |
| 8 | AFAP1-AS1: a rising star among oncogenic long non-coding RNAs显示文摘Long non-coding RNAs(lncRNAs)have become a hotspot in biomedical research.This interest reflects their extensive involvement in the regulation of the expression of other genes,and their influence on the occurrence and development of a variety of human diseases.Actin filament associated protein 1-Antisense RNA 1(AFAP1-AS1)is a recently discovered oncogenic lncRNA.It is highly expressed in a variety of solid tumors,and regulates the expression of downstream genes and signaling pathways through adsorption and competing microRNAs,or by the direct binding to other proteins.Ultimately,AFAP1-AS1 promotes proliferation,chemotherapy resistance,and resistance to apoptosis,maintains stemness,and enhances invasion and migration of tumor cells.This paper summarizes the research concerning AFAP1-AS1 in malignant tumors,including the clinical application prospects of AFAP1-AS1 as a potential molecular marker and therapeutic target of malignant tumors.We also discuss the limitations in the knowledge of AFAP1-AS1 and directions of further research.AFAP1-AS1 is expected to provide an example for studies of other lncRNA molecules. | Fang Xiong Kunjie Zhu Su Deng Hongbin Huang Liting Yang Zhaojian Gong Lei Shi Yi He Yanyan Tang Qianjin Liao Jianjun Yu Xiaoling Li Yong Li Guiyuan Li Zhaoyang Zeng Wei Xiong Shanshan Zhang Can Guo | 2021 | Science China(Life Sciences)2021，64，10： | 4 |
| 9 | 3D microstructures of nuclear graphite:IG-110,NBG-18 and NG-CT-10显示文摘Molten salt is used as primary coolant flowing through graphite moderator channel of a molten salt reactor.Working at high temperature under radiation environment,the pore network structure of nuclear graphite should be well understood.In this paper,X-ray tomography is employed to study the 3D pore structure characteristics of nuclear grades graphite of IG-110,NBG-18 and NG-CT-10,and permeability simulation through geometries are performed.The porosity,number of pores and throats,coordination number and pore surface are obtained.NGCT-10 is of similar microstructure to IG-110,but differs significantly from NBG-18.The absolute permeabilities of IG-110,NG-CT-10 and NBG-18 are 0.064,0.090 and0.106 mD,respectively.This study provides basis for future research on graphite infiltration experiment. | Shi-Pei Jing Can Zhang Jie Pu Hong-Yan Jiang Hui-Hao Xia Fang Wang Xu Wang Jian-Qiang Wang Chan Jin | 2016 | Nuclear Science and Techniques2016，27，3： | 3 |
| 10 | Effects and mechanisms of innate immune molecules on inhibiting nasopharyngeal carcinoma显示文摘To the Editor: The nasopharyngeal ep让helium is frequently exposed to various harmful carcinogens. When the nasopharvngeal mucosa is damaged, local inflammation is induced.[1] Chronic inflammation of the nasopharyngeal epithelium may eventually evolve into nasopharyngeal carcinoma (NPC). While the mucus secreted by the nasopharyngeal epithelium forms the body's primitive immune protection barrier as it contains a series of proteins and peptides that can sense, bind, degrade and remove various harmful substances. Lactotransferrin (LTF)[2] and bactericidal/permeability-increasing (BPI) protein family members[3] are an important component of the innate immune protection barrier. | Fang Xiong Su Deng Hong-Bin Huang Xia-Yu Li Wen-Ling Zhang Qian-Jin Liao Jian Ma Xiao-Ling Li Wei Xiong Gui-Yuan Li Zhao-Yang Zeng Can Guo | 2019 | Chinese Medical Journal2019，，6： | 3 |
| 11 | Core muscle functional strength training for reducing the risk of low back pain in military recruits:An open-label randomized controlled trial显示文摘Background:Core muscle functional strength training(CMFST)has been reported to reduce injuries to the lower extremity.However,no study has confirmed whether CMFST can reduce the risk of low back pain(LBP).Objective:This study identified the effects of CMFST on the incidence of LBP in military recruits.Design,setting,participants and intervention:We performed a prospective,open-label,randomized,controlled study in a population of young healthy male naval recruits from a Chinese basic combat training program.Participants were randomly assigned to either the core group or the control group.In additional to normal basic combat training,recruits in the core group underwent a CMFST program for 12 weeks,while recruits in the control group received no extra training.Main outcome measures:At the beginning of the study and at the 12 th week,the number of participants with LBP was counted,and lumbar muscle endurance was measured.In addition,when participants complained of LBP,they were assessed using the visual analog scale(VAS)and Roland Morris Disability Questionnaire(RMDQ).Results:A total of 588 participants were included in the final analysis(295 in the core group and 293 in the control group).The incidence of LBP in the control group was about twice that of the core group over the 12-week study(20.8%vs 10.8%,odds ratio:2.161–2.159,P<0.001).The core group had better lumbar muscle endurance at 12 weeks than the control group([200.80±92.98]s vs[147.00±84.51]s,P<0.01).There was no significant difference in VAS score between groups,but the core group had a significantly lower RMDQ score at week 12 than the control group(3.33±0.58 vs 5.47±4.41,P<0.05).Conclusion:This study demonstrated that the CMFST effectively reduced the incidence of LBP,improved lumbar muscle endurance,and relieved the dysfunction of LBP during basic military training. | Xin Wang Wen-juan Song Yi Ruan Bing-chu Li Can Lü Nian Huang Fan-fu Fang Wei Gu | 2022 | Journal of Integrative Medicine2022，20，2： | 3 |
| 12 | Gene duplication drove the loss of awn in sorghum.显示文摘Loss of the awn in some cereals including sorghum is a key transition during cereal domestication or improvement that has facilitated grain harvest and storage.The genetic basis for the loss of awn in sorghum during domestication or improvement remains unknown.Here,we identified a transcription factor gene awn1 encoding an ALOG domain,which is responsible for awn loss during sorghum domestication or improvement.awn1 arose from a gene duplication from chromosome 10 that translocated to chromosome 3,recruiting a new promoter from the neighbouring intergenic region filled with'noncoding DNA',and recreating the first exon and intron.The awn1 acquires high expr`ession after duplication and represses the elongation of awns in domesticated sorghum.Comparative mapping revealed a high collinearity at awn1 paralog locus on chromosome 10 across cereals and awn growth and development was successfully reactivated on the rice spikelet by inactivating rice awn1 orthologue.Further RNA-seq and DAP-seq revealed that as a transcription repressor,AWN1 directly bound to the motif in the regulatory regions from three MADS genes related to flower development and two genes DL and LKS2 for the development of awn,downregulated the expressions of these genes,and then repressed the elongation of awn.The preexistence of regulatory elements in the neighbouring intergenic region of awn1 before domestication signified that noncoding DNA may serve as a treasure trove for evolution during adaptation to a changing world.Our results supported that gene duplication can promptly drive the evolution of gene regulatory network. | Leina Zhou Can Zhu Xiaojian Fang Hangqin Liu Shuyang Zhong Yan Li Jiacheng Liu Yang Song Xing Jian Zhongwei Lin | 2021 | Molecular Plant2021，14，11： | 2 |
| 13 | The Effects of Hydrogen-Rich Saline on the Contractile and Structural Changes of Intestine Induced by Ischemia-Reperfusion in Rats显示文摘 | Han Chen Yan Ping Sun Ping Fang Hu Wen Wu Liu Hong Gang Xiang Yang Li Rong Lin Yan Ning Su Can Ping Ruan Xue Jun Sun Qiang Wang | 2011 | Journal of Surgical Research2011，，2： | 2 |
| 14 | In-situ generation and global property profiling of metal nanoclusters by ultraviolet laser dissociation-mass spectrometry显示文摘Metal nanoclusters are promising nanomaterials with unique properties, but only a few ones with specific numbers of metal atoms can be obtained and studied up to now. In this study, we establish a new paradigm of in-situ generation and global study of metal nanoclusters with different sizes, constitutions, and charge states, including both accurate constitution characterization and global activity profiling. The complex mixtures of metal nanoclusters are produced by employing single-pulsed 193-nm laser dissociation of monolayer-protected cluster(MPC) precursors within a high-resolution mass spectrometry(HRMS). More than400 types of bare gold nanoclusters including novel multiply charged(2+ and 3+), S-/P-doped, and silver alloy ones can be efficiently generated and accurately characterized. A distinct size(1 to 142 atoms)-and charge(1+ to 3+)-hierarchy reactivity is clearly observed for the first time. This global cluster study might greatly promote the developments and applications of novel metal nanoclusters. | Zheyi Liu Zhaoxian Qin Chaonan Cui Zhixun Luo Bing Yang You Jiang Can Lai Zhipeng Wang Xiaolei Wang Xiang Fang Gao Li Fangjun Wang Chunlei Xiao Xueming Yang | 2022 | Science China Chemistry2022，65，6： | 2 |
| 15 | Preparation,structure,luminescence properties of europium doped zinc spinel structure green-emitting phosphor ZnAl_2O_4:Eu^(2+)显示文摘The Zn_(1-x)Al_2 O_4:xEu^(2+) phosphor powders were synthesized by the solid-state reaction method.The synthesis temperature for ZnAl_2 O_4 was optimized,whereas the phase structure,TEM images,photoluminescence(PL) properties,the concentration quenching mechanism,the fluorescence decay curves,as well as the CIE chromaticity coordinates of the samples were investigated in details.Under the excitation at 379 nm,the phosphor exhibits an asymmetric broad-band green emission with a peak at 532 nm,which is ascribed to the 5 d-4 f transition of Eu2+.When the doping concentration of Eu2+ ions is 0.01,the luminescence intensity of the sample reaches the maximum value.It is further proved that the exchange interaction results in the concentration quenching of Eu2+ in the Zn_(1-x)Al_2 O_4:xEu^(2+) phosphor powders.The thermal quenching property of ZnAl_2 O_4:Eu^(2+)phosphor was investigated and the quantum efficiency(QE) values of the selected Zn_(0.99)Al_2 O_4:0.01 Eu^(2+) phosphor was measured and determined as 54.85%.The lifetime of the optimized sample Zn_(0.99)Al_2 O_4:0.01 Eu^(2+) is 3.0852 μs and the CIE coordinate of the sample was calculated as(0.3323,0.5538) with high-color-purity green emission.All properties indicate that the green-emitting ZnAl_2 O_4:Eu^(2+) phosphor powder has potential application in white LEDs. | Can He Haipeng Ji Zhaohui Huang Xiaoguang Zhang Yan'gai Liu Minghao Fang Xiaowen Wu Xin Min | 2018 | Journal of Rare Earths2018，36，9： | 2 |
| 16 | Genetic variation in the VP4 and NSP4 genes of human rotavirus serotype 3 (G3 type)isolated in China and Japan 显示文摘 | Can XR Akihara S Fang ZY | 1999 | Microbiol Immunol1999，43，2： | 1 |
| 17 | An integrated approach to fatigue life prediction of hole system for offshore platforms显示文摘 | Fang Hua Can Duan Meng Lan Wu Yong Ning | | China Ocean Engineering0，，： | 1 |
| 18 | Correlation between Anxiety,Depression,and Sleep Quality in College Students显示文摘Sleep disorders will lead to difficulties in entering or maintaining sleep. Short-term sleep disorders will affect people’s attention and memory, and longterm sleep disorders will lead to a decline in human immunity and induce some potential physical diseases and psychological diseases such as anxiety symptoms and depressive symptoms. Facing pressure from study, life, employment, and other aspects, college students are prone to depressive symptoms, anxiety symptoms, sleep disorders, and other problems. | ZHANG Yu Tong HUANG Tao ZHOU Fang HUANG Ao Di JI Xiao Qi HE Lu GENG Qiang WANG Jia MEI Can XU Yu Jia YANG Ze Long ZHAN Jian Bo CHENG Jing | 2022 | Biomedical and Environmental Sciences2022，35，7： | 1 |
| 19 | UV Raman spectroscopic study on TiO2(Ⅰ): Phase transformation at the surface and in the bulk显示文摘 | Zhang Jing Li Meijun Fang Zhaochi Chen Jun Li Can | 2006 | The Journal of Physical Chemistry B2006，110，： | 1 |
| 20 | Endotoxin contamination and control in surface water sources and a drinking water treatment plant in Beijing, China显示文摘 | Zhang Can Liu Wenjun Sun Wen Zhang Minglu Qian Lingjia Li Cuiping Tian Fang | 2013 | Water Research2013，，11： | 1 |
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