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| 1 | Biological drug and drug delivery-mediated immunotherapy显示文摘The initiation and development of major infammatory diseases,i.e.,cancer,vascular infammation,and some autoimmune diseases are closely linked to the immune system.Biologics-based immunotherapy is exerting a critical role against these diseases,whereas the usage of the immunomodulators is always limited by various factors such as susceptibility to digestion by enzymes in vivo,poor penetration across biological barriers,and rapid clearance by the reticuloendothelial system.Drug delivery strategies are potent to promote their delivery.Herein,we reviewed the potential targets for immunotherapy against the major infammatory diseases,discussed the biologics and drug delivery systems involved in the immunotherapy,particularly highlighted the approved therapy tactics,and finally offer perspectives in this feld. | Qingqing Xiao Xiaotong Li Yi Li Zhenfeng Wu Chenjie Xu Zhongjian Chen Wei He | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 15 |
| 2 | Estimation of carbon sinks in chemical weathering in a humid subtropical mountainous basin显示文摘The fluvial geochemistry of the mainstream and tributaries of the Zengjiang River was investigated,and the mass balance approach and deduction methods were used to estimate the uptake of atmospheric CO2 through rock chemical weathering.The results showed that the chemical runoff mainly consisted of HCO3-,Ca2+,Na+,and dissolved Si,and that silicate mineral weathering was significant,but carbonate mineral weathering was a minor source of dissolved loads in the Zengjiang River basin because of the low amount of interlayered carbonate rock strata in the catchment.The ion composition indicated that atmospheric CO2 was the primary erosive agent for rock chemical weathering in the Zengjiang River basin.The CO2 consumption fluxes caused by rock chemical weathering were(3.50-3.81) × 105 mol km-2 a-1,which is just lower than that in tropical and subtropical basalt and carbonate regions,and is much higher than that in temperate and cold-temperate regions,indicating that surficial chemical weathering processes in the humid and hot monsoon current influencing the low-middle latitude zone of the Northern Hemisphere constitutes a significant carbon sink in the global biogeochemical cycle. | TAO Zhen GAO QuanZhou WANG ZhenGang ZHANG ShengHua XIE ChenJi LIN PeiSong RUAN XiaoBing LI ShuHong MAO HaiRuo | 2011 | Chinese Science Bulletin2011，56，35： | 15 |
| 3 | Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation显示文摘Subject Code:H16With the support by the National Natural Science Foundation of China,a collaborative study by the research groups led by Prof.Wang Chenji(王陈继)from Fudan University,Prof.Huang Haojie(黄浩杰)from Mayo Clinic and Sun Yinhao(孙颖浩)from the Second Military Medical University have | Wang Chenji (王陈继) Huang Haojie (黄浩杰) Sun Yinhao (孙颖浩) | 2017 | Science Foundation in China2017，25，3： | 15 |
| 4 | Pedodiversity: A Case Study Based on 1:1 Million Scale SOTER of Shandong Province, China显示文摘The diversity of soils derived from different parent materials and developed on different terrains inShandong Province, China, was analyzed with the theory of pedodiversity using a 1:1000000 scale soilsand terrain digital database (SOTER) of Shandong Province in a geographical information system (GIS)environment. Diversity index of soils derived from different parent materials followed the sequence of igneousrock > sedimentary rock > metamorphic rock > unconsolidated material. Diversity index of soils developedon different terrains followed the sequence of plain > medium-gradient mountain > medium-gradient hill> valley floor > medium-gradient escarpment zone > depression > high-gradient mountain. Abundancedistributions of these soil groups matched the logarithmic normal distributions. | TANMANZHI ZHANGXUELEI CHENJIE YANWUJIU YANGYUJIAN | 2003 | Pedosphere2003，13，3： | 12 |
| 5 | Impact of land use change on soil resources in the peri-urban area of Suzhou city显示文摘The Yangtze delta area is among the fastest developing areas in China. Here there are mega-cities like Shanghai, Nanjing and the attached urban areas of different sizes including those along the lower reaches of the Yangtze River from Shanghai up to Nanjing as well as their satellite cities and towns, forming one of the most densely distributed urban areas in China. This is a case study done in Suzhou city at the center of the Yangtze delta to reflect the impact of urban sprawl on soil resources using satellite images and digital soil databases. The extent of the developed land in the studied area and the impact of development on soil resources at 1:100,000 scale are estimated and the soil types impacted most by urbanization development are determined through overlaying the soil map on the satellite images (Landsat-7) of the studied area at different times (1984, 1995, 2000 and 2003). The methodology for this study consists of analyzing data resulting from using a geographic information system (GIS) to combine urban land use maps of different times derived from satellite images with data on soil characteristics contained in the established soil databases by which some results come into being to present the fast expanding trend of urbanization in the Yangtze delta area, the urban spread and the soils occupied by the urbanization process, and also the quality of the occupied soils. | ZHANGXuelei TANManzhi CHENJie SUNYanci | 2005 | Journal of Geographical Sciences2005，15，1： | 10 |
| 6 | Pedodiversity analysis in Hainan Island显示文摘Diversity indices and abundance distribution models are statistical tools which ecologists have applied for decades for analyzing the intrinsic regularities of various ecological entities. In this work, we have applied these techniques to use the notions such as pedodiversity (as an example of geodiversity in a broad sense), in order to detect the differences and similarities between both natural resources, biological and non-biological. The discussion has mainly been conducted through the study of landform based pedodiversity analysis applied to SOTER digital databases in Hainan Island, China. The main analytical methods include indices of richness S that are the number of the categories (SOTER units relating to different soils in this work), indices based on proportional abundance of categories H’ and E which are not only the number but also their relative abundance (in our case, the relative area occupied by each pedotaxa) is taken into account, models of the distribution of abundance of categories that provide the most complete description but also the least abridged and GIS mapping to show the spatial variation digitally. | ZHANGXuelei CHENJie ZHANGGanlin TANManzhi J.J.Ibanez | 2003 | Journal of Geographical Sciences2003，13，2： | 8 |
| 7 | Microbiota transplantation reveals beneficial impact of berberine on hepatotoxicity by improving gut homeostasis显示文摘Berberine has been shown to reduce acute liver injury although the underlying mechanism is not fully understood. Because of the anatomic connection, the liver is constantly exposed to gut-derived bacterial products and metabolites. In this study, we showed that berberine has beneficial effects on both hepatotoxicity and intestinal damage in a rat model of chronic or acute liver injury. Microbiota transplantation from the rats with chronic hepatotoxicity could aggravate acute hepatotoxicity in mice treated with diethylnitrosamine(DEN). In rat models with gut homeostasis disruption induced by penicillin or dextran sulfate sodium(DSS), their fecal microbiota could also cause an enhanced hepatotoxicity of recipient mice. When treated with berberine,the DSS-induced enteric dysbacteriosis could be mitigated and their fecal bacteria were able to reduce acute hepatotoxicity in recipient mice. This study indicates that berberine could improve intestinal dysbacteriosis, which reduces the hepatotoxicity caused by pathological or pharmacological intervention. Fecal microbiota transplantation might be a useful method to directly explore homeostatic alteration in gut microbiota. | Chenjie Qin Huilu Zhang Linghao Zhao Min Zeng Weijian Huang Gongbo Fu Weiping Zhou Hongyang Wang Hexin Yan | 2018 | Science China(Life Sciences)2018，61，12： | 8 |
| 8 | Role of Lichens in Weathering and Soil-Forming Pro-cesses in Fildes Peninsula,Antarctic显示文摘RoleofLichensinWeatheringandSoil-FormingPro-cessesinFildesPeninsula,AntarcticHENJIEandGONGZi-TONG(InstituteofSoilScience,Acad... | CHENJIE GONGZi-TONG | 1995 | Pedosphere1995，5，4： | 7 |
| 9 | A Concise Review of Gold Nanoparticles-Based Photo-Responsive Liposomes for Controlled Drug Delivery显示文摘The focus of drug delivery is shifting toward smart drug carriers that release the cargo in response to a change in the microenvironment due to an internal or external trigger. As the most clinically successful nanosystem, liposomes naturally come under the spotlight of this trend. This review summarizes the latest development about the design and construction of photo-responsive liposomes with gold nanoparticles for the controlled drug release. Alongside, we overview the mechanism involved in this process and the representative applications. | Malathi Mathiyazhakan Christian Wiraja Chenjie Xu | 2018 | Nano-Micro Letters2018，10，1： | 7 |
| 10 | Polymeric biomaterials for biophotonic applications显示文摘With the growing importance of optical techniques in medical diagnosis and treatment,there exists a pressing need to develop and optimize materials platform for biophotonic applications.Particularly,the design of biocompatible and biodegradable materials with desired optical,mechanical,chemical,and biological properties is required to enable clinically relevant biophotonic devices for translating in vitro optical techniques into in situ and in vivo use.This technological trend propels the development of natural and synthetic polymeric biomaterials to replace traditional brittle,nondegradable silica glass based optical materials.In this review,we present an overview of the advances in polymeric optical material development,optical device design and fabrication techniques,and the accompanying applications to imaging,sensing and phototherapy. | Dingying Shan Ethan Gerhard Chenji Zhang John William Tierney Daniel Xie Zhiwen Liu Jian Yang | 2018 | Bioactive Materials2018，3，4： | 6 |
| 11 | FLOW PATTERN AND PRESSURE LOSS OF OIL-WATER TWO-PHASE FLOW IN HORIZONTAL STEEL PIPE显示文摘Experimental Study on oil-water two-phase flow patterns and pressure loss was conducted on a horizontal steel pipe loop with 26.1mm inner diameter and 30m total length. The working fluids are white oil, diesel oil and tap water. Several instruments, including a new type of liquid-probe are successfully integrated to identify 7 different flow patterns. The characteristics of the flow patterns and the transition process were observed and depicted in this paper. Investigation revealed that the pressure loss was mainly depended on the flow patterns. | CHENJie YANDa-fan ZHAOJing-mei ANWei-jie YANDa-chun | 2005 | Journal of Hydrodynamics2005，17，2： | 5 |
| 12 | Interleaving distribution of multifractal strength of 16-channel EEG signals显示文摘Multifractal characteristics of 16-channel hu-man electroencephalogram (EEG) signals under eye-closed rest are analyzed for the first time. The result shows that the EEGs from the different sites on the scalp have different multifractal characteristics and the multifractal strength value a exhibits a kind of interleaving and left-right oppo-site distribution on scalp. This distribution rule is consistent with the localization of function and the lateralization theory in physiology. So Da can become an effective parameter to describe the brain potential character. And such a a stable distribution rule on sites of the scalp means a classic cerebral cortex active state. | WANGWei NINGXinbao WANGJun ZHANGSheng CHENJie LILejia | 2003 | Chinese Science Bulletin2003，48，16： | 5 |
| 13 | Cytosolic delivery of the immunological adjuvant PolyⅠ:C and cytotoxic drug crystals via a carrier-free strategy significantly amplifies immune response显示文摘Co-delivery of chemotherapeutics and immunostimulant or chemoimmunotherapy is an emerging strategy in cancer therapy.The precise control of the targeting and release of agents is critical in this methodology.This article proposes the asynchronous release of the chemotherapeutic agents and immunostimulants to realize the synergistic effect between chemotherapy and immunotherapy.To obtain a proof-of-concept,a co-delivery system was prepared via a drug-delivering-drug(DDD)strategy for cytosolic co-delivery of Poly I:C,a synthetic ds RNA analog to activate RIG-I signaling,and PTX,a commonly used chemotherapeutics,in which pure PTX nanorods were sequentially coated with Poly I:C and mannuronic acid via stimulating the RIG-I signaling axis.The co-delivery system with a diameter of 200 nm enables profound immunogenicity of cancer cells,exhibiting increased secretion of cytokines and chemokines,pronounced immune response in vivo,and significant inhibition of tumor growth.Also,we found that intracellularly sustained release of cytotoxic agents could elicit the immunogenicity of cancer cells.Overall,the intracellular asynchronous release of chemotherapeutics and immunomodulators is a promising strategy to promote the immunogenicity of cancer cells and augment the antitumor immune response. | Xiaoqing Du Yuqi Hou Jia Huang Yan Pang Chenlu Ruan Wei Wu Chenjie Xu Hongwei Zhang Lifang Yin Wei He | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 3 |
| 14 | Hydroxycalciopyrochlore, A New Mineral Species from Sichuan, China显示文摘Hydroxycalciopyrochlore, ideally(Ca,Na,U,□)2(Nb,Ti)2O6(OH), cubic, is a new mineral species(IMA2011-026) within the pyrochlore supergroup that was found occurring at the Maoniuping mine, Mianning County, Xichang prefecture, Sichuan Province, southwest China. The mineral is found in an alkali feldspar granite rare-earth ore deposit(26–27 Ma). Associated minerals include calcite, barite, celestine, albite, aegirine, aegirine-augite, fluorite, parasite-(Ce), thorite, thorianite, zircon, galena, sphalerite, magnetite, and pyrite. Crystals occur mostly as octahedra, and less often as dodecahedra and tetrahexahedra or combinations thereof. Some occur with an allotriomorphic habit with a thick triangular tabular form. Crystals generally range from 0.1 to 1 mm in size. The mineral is brownishblack, greenish-black and black on fresh sections with a brown streak. The crystal is translucent, and has a greasy lustre on fresh sections. It is metamict without any observed parting or cleavage and with a conchoidal fracture. The Vickers microhardness is 572 kg/mm2(5–6 on the Mohs hardness scale). The density measured by hydrostatic weighing is 5.10(3) g/cm3. The strongest four reflections in the X-ray powder-diffraction pattern [d in(I) hkl] are: 2.9657(100) 2 2 2, 1.8142(34) 0 4 4, 1.5463(21) 2 2 6, 2.5688(18) 0 0 4. The unit-cell parameters are a = 10.381(4), V = 1118.7(7)3, Z = 8. The structure was solved and refined in the space group Fd3m with R = 0.09. The empirical formula is(Ca0.74Na0.58U0.40Ce0.05Fe0.02□0.21)2.00(Nb1.15Ti0.80Ta0.03Al0.01Mg0.01)2.00O6.02 [(OH)1.01F0.09]1.10, on the basis of 2 atoms of B pfu; the simplified formula is(Ca,Na,U,□)2(Nb,Ti)2O6(OH). Type material is deposited in the Geological Museum of China, Beijing, People's Republic of China, catalogue number M11800. | YANG Guangming LI Guowu XIONG Ming PAN Baoming YAN Chenjie | 2014 | Acta Geologica Sinica(English Edition)2014，88，3： | 3 |
| 15 | Temporal and Spatial Variability of Dissolved Organic Carbon Concentration in the Xijiang River, South China显示文摘A whole year analysis of riverine dissolved organic carbon (DOC) concentrations in the Xijiang River (XJR), South China, showed that the mean riverine DOC concentration (1.24 mg L-1) in the XJR was notably lower than the averaged value (5.75 mg L-1) of the global riverine DOC concentration in several major rivers. There is an inconspicuous monthly fluctuation of the DOC signal in the XJR, but on a semi-yearly time scale, however, the riverine DOC concentration had significant difference between hydrological seasons. The DOC level during the flood season (1.18 mg L-1) was less than that during the non-flood season (1.40 mg L-1). Owing to the concomitance of the flushing and dilution effects of the runoff during the high-water period, the variation of riverine DOC concentration with discharge in the XJR differed from that reported in many other major rivers. The DOC export flux above the city of Wuzhou was about 0.62× 106 g C km-2 yr-1. The DOC transported during the '056' Massive Flood period comprised 30.35% of the annual total, while the discharge accounted for 36.32% of the total annual flow. The characteristics in riverine DOC concentration in the XJR were attributed to the combined effect of the geomorphologic, monsoon climatic and hydrological processes as well as land-use within the drainage basin. | TAO Zhen GAO Quanzhou GUO Wenping WANG Zhengang ZHANG Yongling XIE Chenji HUANG Xiakun ZHONG Hongwei | 2011 | Journal of Mountain Science2011，8，5： | 3 |
| 16 | Chromosomal-level genome of macadamia(Macadamia integrifolia)显示文摘Macadamia from the family Proteaceae is a plant native to Australia and has long been favoured by people for its crispy and high nutritional and medicinal value.Here,the genome of GUIRE 1(GR1),a highly heterozygous superior cultivar of macadamia nut,was sequenced and assembled using nanopore sequencing,and a 807-Mb genome(contig N50,1.9 Mb;scaffold N50,54.70 Mb)and 14 chromosomes were obtained.A total of 453 Mb(about 55.95%)repetitive sequences and 37,657 protein-coding genes were obtained by gene annotation and homologous protein comparison.Proteaceae diverged from Nelumbonaceae nearly 115.37 million years ago and from Rubiaceae about 140 million years ago.A genome-wide duplication(WGD)event occurred in macadamia 41 million years ago based on the WGD analysis.The functional enrichment analysis of M.integrifolia-specific gene families revealed their roles in signal transduction,protein phosphorylation,protein binding,and defense response.Here,a highly heterozygous genome of M.integrifolia was unlocked to provide a database for breeding and molecular mechanism research. | Chengcai Xia Sirong Jiang Qiujin Tan Wenquan Wang Long Zhao Chenji Zhang Yuting Bao Qi Liu Jianjia Xiao Ke Deng Miaohua He Pengliang An Wenlin Wang Meiling Zou Zhiqiang Xia | 2022 | Tropical Plants2022，1，1： | 3 |
| 17 | Observation and Research on Gravitational Erosion Process of Bank Slopes in Headstream Area of Jiangjia Ravine, Yunnan, China显示文摘To reveal the gravitational erosion process in the headstream area of Jiangjia Ravine, continuous observation was conducted duing the rainy season. The observation and research show that the change of water content of the bank slope lags the precipitation process, the infiltration water concentrates mainly in the shallow layer of the bank slope, also the bank slope was unsaturated, the floods and debris flows in the gully down cut the gully bed, and scour the foot of the bank slope. These results in many collapses, which is the main type of gravitational erosion process, and it provides large amounts of loose solid materials for the eruption of debris flows. | FENGZi-li CUIPeng CHENXiao-qin CHENJie ZHUYin-yan | 2005 | Wuhan University Journal of Natural Sciences2005，10，4： | 2 |
| 18 | Effect of microelement and chemical fungicides on biocontrol effect of Trichoderma T23显示文摘Recently there have been many reports about soil diseases controlled by Trichoderma, but few could be applied on agriculture production in large areas. T23 isolated from soil around plant roots in the field by Biopesticide Engineering Center of Shenyang Agricultural University could control effectively Cucurbits Fusarium Wilt. The effects of 9 microelements which include copper, zinc, iron, boron, molybdenum, calcium, manganese, magnesium, potassium and frequently-used chemical fungicides, such as-carbendazim, thiram, thiophanate-methyl, chlorothalonil and hymexazol on the growth and the amounts of spores of Fusarium oxysporum FJ and Trichoderma T23 were studied. The effects of those factors on control effect of T23 to melon diseases were discussed and gave basis for the screening of synergistic agents and fungicides in controlling synergistically the pathogen. The results showed that copper sulfate, zinc sulfate, ferric sulfate and boric acid at concentration of 10-1000 μg/mL had the stronger inhibition to F. oxysporum, while weaker inhibition to Trichoderma. Ammonium molybdate, ferrous sulfate, calcium sulfate and potassium dihydrogen phosphate were the ideal the synergistic agent for accelerating the growth and sporulation of Trichoderma, and germination of melon seeds and growth of melon radicle. Melon Fusarium wilt was controlled by Trichoderma combined with ammonium molybdate and calcium sulfate. The relative control effect reached to 73.95%-71.36%. Several fungicides used generally in soil had a different effect on the growth of F. oxysporum and Trichoderma. Carbendazim appeared a strong inhibition to the growth of two strains, with EC50 of 3.01 mg/L and 0.75. mg/L, respectively. Trichoderma had the strong resistance to thiram which control to Fusarium oxysporum was not ideal in field. Hymexazol which EC50 was 261 mg/L and Trichoderma had the synergistical effect on controlling to F. oxysporum. Trichoderma could reproduce in soil treated with hymexazol at ratio of 2000-4000. Relative control effect of hymexazol combined with Trichoderma to oxysporum reached to 79.26%,. which was higher by 15.19% and 38.75% than the solo controlling effect respectively. | ZHUANGJing-hua GAOZeng-gui YANGChang-cheng LIUXian CHENJie | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 2 |
| 19 | Dual confinement of polysulfides in boron-doped porous carbon sphere/graphene hybrid for advanced Li-S batteries显示文摘由做硼的多孔的碳范围和 graphene (BPCS-G ) 组成的混合结构被设计了并且向解决 polysulfide 梭问题综合了,它是当前的 Li-S 电池的最关键的问题。显示出高表面区域的建议混合结构(870 m 2??????????????? ? €畧湡湩?? 挠瑹獯湩 ?????? ㄠ‰ ????????????? 吠 ?? €?‰ ??????? ‰ ?????????????????????????? ￡桴?? | Wei Ai Jiewei Li Zhuzhu Du Chenji Zou Hongfang Du Xin Xu Yu Chen Hongbo Zhang Jianfeng Zhao Changming Li Wei Huang Ting Yu | 2018 | Nano Research2018，11，9： | 2 |
| 20 | Recent advance of chemoenzymatic catalysis for the synthesis of chemicals: Scope and challenge显示文摘Chemoenzymatic catalysis can give full play to the advantages of versatile reactivity of chemocatalysis and excellent chemo-,regio-,and stereoselectivities of biocatalysis.These chemoenzymatic methods can not only save resource,cost,and operating time but also reduce the number of reaction steps,and avoid separating unstable intermediates,leading to the generation of more products under greener circumstances and thereby playing an indispensable role in the fields of medicine,materials and fine chemicals.Although incompatible challenges between chemocatalyst and biocatalyst remain,strategies such as biphasic system,artificial metalloenzymes,immobilization or supramolecular host,and protein engineering have been designed to overcome these issues.In this review,chemoenzymatic catalysis according to different chemocatalysis types was classifiably described,and in particular,the classic dynamic kinetic resolutions(DKR)and cofactor regeneration were summarized.Finally,the bottlenecks and development of chemoenzymatic catalysis were summarized,and future development was prospected. | Mengjiao Xu Zhuotao Tan Chenjie Zhu Wei Zhuang Hanjie Ying Pingkai Ouyang | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 2 |
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