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| 1 | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma显示文摘AIM: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma.METHODS: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular carcinoma.CONCLUSION: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. | Myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey | 2006 | World Journal of Gastroenterology2006，12，41： | 11 |
| 2 | Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。 | Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng | 2009 | Cell Research2009，19，3： | 9 |
| 3 | Silicon carbide resonant tuning fork for microsensing applications in high-temperature and high G-shock environments显示文摘We present the fabrication and testing of a silicon carbide(SiC)balanced mass double-ended tuning fork that survives harsh environments without compromising the device strain sensitivity and resolution bandwidth.The device features a material stack that survives corrosive environments and enables high-temperature operation.To perform high-temperature testing,a specialized setup was constructed that allows the tuning fork to be characterized using traditional silicon electronics.The tuning fork has been operated at 600 ℃ in the presence of dry steam for short durations.This tuning fork has also been tested to 64 000 G using a hard-launch,soft-catch shock implemented with a light gas gun.However,the device still has a strain sensitivity of 66 Hz/με and strain resolution of 0.045 με in a 10 kHz bandwidth.As such,this balanced-mass double-ended tuning fork can be used to create a variety of different sensors including strain gauges,accelerometers,gyroscopes,and pressure transducers.Given the adaptable fabrication process flow,this device could be useful to micro-electro-mechanical systems(MEMS) designers creating sensors for a variety of different applications. | David R Myers Kan Bun Cheng Babak Jamshidi Robert G Azevedo Debbie G Senesky Li Chen Mehran Mehregany Muthu B J Wijesundara Albert P Pisano | 2012 | Engineering Sciences2012，10，5： | 6 |
| 4 | Influence of deposition parameters on the internal stress in a-C:H films显示文摘 | Cheng Y H Wu Y P Chen J G | 1999 | Surface and Coating Technol1999，111，： | 2 |
| 5 | Organochlorine pesticides, polybrominated biphenyl ethers and lead isotopes during the spring time at the waliguan baseline observatory, northwest China: Implication for long-range atmospheric transport 显示文摘 | CHENG H R ZHANG G JIANG J X Y | 2007 | Atmospheric Environment2007，，41： | 1 |
| 6 | The leukemia-associated cytoplasmic nucleophosmin mutant is an oncogene with paradoxical functions : Arf inactivation and induction of cellular senescence 显示文摘 | Cheng K Grisendi S Clohessy J G | 2007 | Oncogene2007，26，53： | 1 |
| 7 | How bacteria stick 显示文摘 | COSTERTON J W GEESEY G G CHENG K J | 1978 | Sci Am1978，238，1： | 1 |
| 8 | Three- dimensional modeling and application in geological exploration engineering显示文摘 | GONG J Y CHENG P G WANG Y D | 2004 | Computers & Geosciences2004，30，4： | 1 |
| 9 | Three-dimensional modeling and application in geological exploration engineering显示文摘 | Gong J Y Cheng P G Wang Y D | 2004 | Computers and Geosciences2004，30，4： | 1 |
| 10 | Growth of(100) -oriented LaNiO3 thin films directly on Si substrates by a simple metalorganic decomposition technique for the highly oriented PZT thin films显示文摘 | Meng X J Cheng J G Sun J L | 2000 | J Cryst Growth2000，220，： | 1 |
| 11 | Three-dimensional Analysis of Heat Transfer in a Micro-heat Sink with Single Phase Flow显示文摘 | Li J Peterson G P Cheng P | 2004 | International Journal of Heat and Mass Transfer2004，47，： | 1 |
| 12 | Direct SERS detection of contaminants in a complex mixture:rapid,single step screening for melamine in liquid infant formula显示文摘 | Betz J F Cheng Y Rubloff G W | 2012 | Analyst2012，137，： | 1 |
| 13 | The effect of calcination temperature on the surface microstructure and photocatalytic activity of TiO2 thin films prepared by liquid phase deposition显示文摘 | YU J G YU H G CHENG B | | 0，，50： | 1 |
| 14 | Study on physical properties and nerve cell affinity of composite films from chitosan and gelatin solutions显示文摘 | CHENG M Y DENG J G YANG F | 2003 | Biomaterials2003，24，： | 1 |
| 15 | The Effect of Calcination Temperature on the Surface Microstructure and Photocatalytic Activity of TiO2 Thin Films Prepared by Liquid Phase Deposition显示文摘 | Yu J G Yu H G Cheng B | 2003 | The Journal of Physical Chemistry B2003，107，13： | 1 |
| 16 | Synthesis and characterization of CBS glass/ceramic composites for LTCC application显示文摘 | CHEN G H TANG L J CHENG J | 2009 | J Alloy Compd2009，478，12： | 1 |
| 17 | Molecular biology and genetics of the Rh blood group system显示文摘 | HUANG C H LIU P Z CHENG J G | 2000 | Semin Hematol2000，37，2： | 1 |
| 18 | PEG-scutellarin prodrugs:Synthesis,water solubility and protective effect on cerebral ischemia/reperfusion injury显示文摘 | Lu J Cheng C M Zhao X G | 2010 | Eur J Med Chem2010，45，5： | 1 |
| 19 | Organochlorine pesticides, po|ybrominated biphenyl ethers and lead isotopes during the spring time at the Waliguan Baseline Observatory, northwest China:implication for long-range atmospheric transport 显示文摘 | CHENG H R ZHANG G JIANG J X | 2007 | Atmos Environ2007，41，： | 1 |
| 20 | Multi-objective optimal planning for designing relief delivery systems显示文摘 | Tzeng G W Cheng H J Huang T D | 2007 | Transportation Research Part E2007，43，6： | 1 |
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