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| 1 | Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system显示文摘允许的技术内长的基因的特定的规定为基因功能的学习是珍贵的并且在治疗学有大潜力。我们创造了在 CRISPR 上系统,由核酸酶死者 Cas9 (dCas9 ) 蛋白质组成的二部件的 transcriptional 使活跃之物与互补顺序与 transcriptional 激活域和单个指南 RNA (sgRNAs ) 熔化了到基因倡导者。我们证明在 CRISPR 上能高效地以一种悦耳的方式在人和老鼠房间激活外长的记者基因。另外,我们证明在 vivo 的柔韧的记者基因激活能被把系统部件注入老鼠接合子完成。而且,我们证明在 CRISPR 上能激活内长的 IL1RN, SOX2,和 OCT4 基因。最有效的基因激活被对近似倡导者有约束力的 3-4 sgRNAs 的簇完成,建议他们在基因正式就职的 synergistic 行动。显著地,当指向多重基因的 sgRNAs 同时被介绍进房间时,柔韧的多路的内长的基因激活被完成。染色体宽的表示介绍表明了系统的高特性。 | Albert W Cheng Haoyi Wang Hui Yang Linyu Shi Yarden Katz Thorold W Theunissen Sudharshan Rangarajan Chikdu S Shivalila Daniel B Dadon Rudolf Jaenisch | 2013 | Cell Research2013，23，10： | 65 |
| 2 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘 | Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste | 2008 | Lancet Neurology2008，，5： | 4 |
| 3 | 循环脂肪因子与超声心动图测量的心脏结构和功能的关系:基于社区的队列研究显示文摘脂肪因子介导与肥胖相关的心脏代谢风险,但它们在肥胖相关心力衰竭的发病机制中的作用仍然不确定。von Jeinsen等调查了社区样本中循环脂肪因子浓度与超声心动图测量的心功能和结构指标之间的关联。研究纳入3514名Framingham心脏研究参与者(平均年龄40岁,53.8%为女性). | 刘莉 叶鹏 von Jeinsen B Short MI Xanthakis V Carneiro H Cheng S Mitchell GF Vasan RS | 2018 | 中华高血压杂志2018，26，8： | 2 |
| 4 | A study on technique to estimate impact location of loose part using Wigner-Ville distribution显示文摘 | KIM Y B KIM S J CHENG H D | 2003 | Progress in Nuclear Energy2003，43，： | 1 |
| 5 | Increased power generation in a continuous flow MFC with advective flow through the porous anode and reduced electrode spacing显示文摘 | Cheng S Liu H Logan B E | 2006 | Environ Sci Technol2006，40，7： | 1 |
| 6 | Extrauterine Pregnancy resulting from ea rly uterine显示文摘 | Cheng E Goff B | 1999 | Obstet Gynecol1999，94，52： | 1 |
| 7 | Increased power generation in a continuous flow MFC with advective flow through the porous anode and reduced electrode spacing显示文摘 | Cheng S Liu H Logan B E | 2006 | Environ Sci Technol2006，40，7： | 1 |
| 8 | Effects of metallic cobalt addition on the performance of pasted nickel electrodes 显示文摘 | YUAN A B CHENG S A ZHANG J Q | 1999 | J Power Sources1999，77，： | 1 |
| 9 | RANSAC-based DARCES: A new approach to fast automatic registration of partially overlapping range images 显示文摘 | Chen S Hung Y P Cheng J B | 1999 | IEEE Transactions on Pattern Analysis and Machine Intelligence1999，21，11： | 1 |
| 10 | Ammonia treatment of carbon cloth anodes to enhance power generation of microbial fuel cells显示文摘 | Cheng S A Logen B E | 2007 | Electrochemistry Communications2007，9，3： | 1 |
| 11 | 查看详情显示文摘 | Liu J Shao S Y Chen L Xie Z Y Cheng Y X Geng Y H Wang L X Jing X B Wang F S | | 0，，14： | 1 |
| 12 | Dual lixiviant leaching process for extraction and re- covery of gold from ores at room temperature 显示文摘 | Zhang J T Shen S B Cheng Y Lan H F Hu X Wang F | 2014 | Hy- drometallurgy2014，144，145： | 1 |
| 13 | The sepa- ration of geochemical anomalies from background by fractal methods 显示文摘 | CHENG Q AGTERBERG F P BALLANTYNE S B | 1994 | Journal of Geochemical Exploration1994，51，2： | 1 |
| 14 | All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination显示文摘 | Kusmartsev S Cheng F Yu B | 2003 | Cancer Res2003，63，15： | 1 |
| 15 | Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis 显示文摘 | Christakos S Mattson M | 1994 | Neuron1994，12，： | 1 |
| 16 | Graphite fiber brush anodes for increased power production in air- cathode microbial fuel cells显示文摘 | Logan B E Cheng S Watson V | 2007 | Environ Sci Technol2007，41，9： | 1 |
| 17 | Effects of short- and long-term elevated CO2 on the expression of Ribulose-1,5-bisphosphate carboxylase/oxygenase genes and carbohydrate accumulation in leaves of Ar abidopsis thaliana 显示文摘 | Cheng S H Moore B D Seemann J R | 1998 | Plant Physiology1998，116，： | 1 |
| 18 | Effects of short-and longterm elevated CO2 on the expression of ribulos-1,5-bisphosphate carboxylase/oxygenase genes and carbohydrate accumulation in leaves of Arabidopsis thaliana (L) Heynh显示文摘 | Cheng S H Moore B Seemann J R | 1998 | Plant Physiol1998，116，： | 1 |
| 19 | Roles of substrate microorganism and urease activities Ⅰ: wastewater purification in a constructed wetland system 显示文摘 | Liang W Wu Z B Cheng S P | 2003 | Ecological Engineer2003，21，： | 1 |
| 20 | Multiuser OFDM with adaptive subcarrier, bit and power allocation 显示文摘 | Wong C Y Cheng R S Letaief K B | 1999 | IEEE J on Select Areas Commun1999，17，10： | 1 |
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