|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Microstructure, biodegradation, antibacterial and mechanical properties of ZK60-Cu alloys prepared by selective laser melting technique显示文摘Magnesium(Mg) alloys are receiving increasing attention for body implants owing to their good biocompatibility and biodegradability. However, they often suffer from bacterial infections on account of their insufficient antibacterial ability. In this study, ZK60-x Cu(x = 0, 0.2, 0.4, 0.6 and 0.8 wt%) alloys were prepared by selective laser melting(SLM) with alloying copper(Cu) to enhance their antibacterial ability.Results showed that ZK60-Cu alloys exhibited strong antibacterial ability due to combination of release of Cu ions and alkaline environment which could kill bacteria by destroying cellular membrane structure,denaturing enzymes and inhibiting deoxyribonucleic acid(DNA) replication. In addition, their compressive strength increased due to grain refinement and uniformly dispersing of short-bar shaped MgZnCu phases. Moreover, ZK60-Cu alloys also exhibited good cytocompatibility. In summary, ZK60-Cu alloys with antibacterial ability may be promising implants for biomedical applications. | Cijun Shuai Long Liu Mingchun Zhao Pei Feng Youwen Yang Wang Guo Chengde Gao Fulai Yuan | 2018 | Journal of Materials Science & Technology2018，34，10： | 12 |
| 2 | Jiang Tang Fang Long Jiao Nang in Treating Non-Insulin Dependent Diabetes Mellitus with Hearing Loss显示文摘Objective To study the efficacy and safety of the Jiang Tang Fang Long Jiao Nang (Hypoglycemic Anti-Deafness Capsule) in treating non-insulin dependent diabetes mellitus with hearing loss. Methods Two hundred ninety six patients with non-insulin dependent diabetes mellitus and hearing loss were randomly assigned to a treatment group(n=164, 208 ears) and a control group(n=132, 184 ears). Patients in the treatment group were treated with the Jiang Tang Fang Long Jiao Nang and supplement herbal preparations as indicated by traditional Chinese medicine dialectical assessment, while control patients received glibenclamide and conventional treatments for deafness. Hearing, fasting blood glucose(FBG), post-prandial blood glucose(PBG), 24 hour urine sugar, platelet function indices, blood superoxide dismutase(SOD) and lipid peroxides(LPO) levels, and symptom improvement were compared between the two groups. Results The rate of hearing improvement was 56.7% for the treatment group and 26.6% for the control. FBG, PBG and 24 hour urine sugar improved in both groups, but the last two were superior in the treatment group compared to the control. Symptoms improvement was also superior in the treatment group compared to the control. In patients receiving Jiang Tang Fang Long Jiao Nang treatment, platelet function indices, SOD and LPO were all improved, while only LOP improvement was noticed in control patients. No acute or long-term toxicity was demonstrated for the Jiang Tang Fang Long Jiao Nang in animal tests. The Jiang Tang Fang Long Jiao Nang lowered blood glucose and serum triglycerides in a rat model of alloxan-induced diabetes. Conclusion The Jiang Tang Fang Long Jiao Nang is effective in improving hearing and diabetic indices in diabetic patients with deafness, without significant side effects. | LI Rui-yu1, LI Meng2, WANG Rui3, LI Bin4, GUO Ya-jing5 1 Xingtai Medical College, Hebei, Xingtai, 054000 2 Chengde Medical college Hebei, Chengde, 067000 3 College of Traditional Chinese Medicine, Hebei Medical University, Shijiazhuang, 050091 4 Department of Biochemistry, Hebei Medicine University 050017 5 Guangzong Hospital of TCM, Hebei, 054600 | 2008 | Journal of Otology2008，3，1： | 7 |
| 3 | Carbon isotopic composition and its implications on paleoclimate of the underground ancient forest ecosystem in Sihui,Guangdong显示文摘We present the carbon isotopic composition of the total organic carbon(TOC) and fine roots in the sedimentary profile from the underground ancient forest in Sihui to study the climatic and environmental changes from 4.5 ka BP to 0.6 ka BP.Results show that C3 plant was the main vegetation from 4.5 ka BP to 0.6 ka BP in this region.The ancient forest began to develop in the wetland at around 4 ka BP and disappeared together with the wetland at about 3.0 ka BP,implying that the climate had changed greatly at around 3.0 ka BP.As indicated by the simulation results,the content of atmospheric CO2 increased slightly during 3.5 ka BP and 3.0 ka BP,implying climate warming during that period.The interval of radiocarbon age between 3.0 ka BP and 1.2 ka BP was possibly caused by the strong erosion when the block was lifted in the neotectonic movement.From 1.2 ka BP to 0.6 ka BP,the region remained in terrestrial sedimentary environment,and the surface plant biomass declined gradually.Drought caused by the climate change was the likely cause for the disappearance of the ancient forest.South transition of Intertropical Convergence Zone(ITCZ) was probably the main mechanism for the climate change. | Ping Ding ChengDe Shen Ning Wang WeiXi Yi KeXin Liu XingFang Ding DongPo Fu | 2009 | Science China Earth Sciences2009，52，5： | 4 |
| 4 | Carbon isotopic composition,turnover and origins of soil CO_2 in a monsoon evergreen broadleaf forest in the Dinghushan Biosphere Reservoir,South China显示文摘Carbon isotopic compositions of soil CO2 in rainy season (July) from two natural soil profiles (DHLS & DHS) in the monsoon evergreen broadleaf forest in the Dinghushan Biosphere Reservoir (DBR),South China,are presented.Turnover and origins of soil CO2 are preliminarily discussed in this paper.Results show that the content of soil CO2 varies between 6120 and 18718 ppmv,and increases with increasing depth until 75 cm,and then it declines.In DHLS,soil CO2 δ 13C ranges from -24.71‰ to -24.03‰,showing a significant inverse correlation (R2=0.91) with the soil CO2 content in the same layer.According to a model related to soil CO2 δ 13C,the soil CO2 is mainly derived from the root respiration (>80%) in DHLS.While in DHS,where soil CO2 δ 13C ranges from -25.19‰ to -22.82‰,soil CO2 is primarily originated from the decomposition of organic matter (51%–94%),excluding the surface layer (20 cm,90%).Radiocarbon data suggest that the carbon in soil CO2 is modern carbon in both DHLS and DHS.Differences in 14C ages between the 'oldest' and 'youngest' soil CO2 in DHLS and DHS are 8 months and 14 months,respectively,indicating that soil CO2 in DHLS has a faster turnover rate than that in DHS.The Δ14C values of soil CO2,which range between 100.0‰ and 107.2‰ and between 102.5‰ and 112.1‰ in DHLS and DHS,respectively,are obviously higher than those of current atmospheric CO2 and SOC in the same layer,suggesting that soil CO2 is likely an important reservoir for Bomb-14C in the atmosphere. | DING Ping SHEN ChengDe WANG Ning YI WeiXi DING XingFang FU DongPo LIU KeXin ZHAO Ping | 2010 | Chinese Science Bulletin2010，55，23： | 4 |
| 5 | Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout显示文摘 | Dong, Zheng Li, Yuan Zhou, Jingru Jiang, Shuai Wang, Yi Chen, Yulin Zhao, Dongbao Yang, Chengde Qian, Qiaoxia Ma, Yanyun He, Hongjun Ji, Hengdong Yang, Yajun Wang, Xiaofeng Xu, Xia Pang, Yafei Zou, Hejian Jin, Li Zhang, Feng Wang, Jiucun | 2017 | Protein & Cell2017，8，6： | 3 |
| 6 | Physical stimulations and their osteogenesis-inducing mechanisms显示文摘Physical stimulations such as magnetic,electric and mechanical stimulation could enhance cell activity and promote bone formation in bone repair process via activating signal pathways,modulating ion channels,regulating bonerelated gene expressions,etc.In this paper,bioeffects of physical stimulations on cell activity,tissue growth and bone healing were systematically summarized,which especially focused on their osteogenesis-inducing mechanisms.Detailedly,magnetic stimulation could produce Hall effect which improved the permeability of cell membrane and promoted the migration of ions,especially accelerating the extracellular calcium ions to pass through cell membrane.Electric stimulation could induce inverse piezoelectric effect which generated electric signals,accordingly up-regulating intracellular calcium levels and growth factor synthesis.And mechanical stimulation could produce mechanical signals which were converted into corresponding biochemical signals,thus activating various signaling pathways on cell membrane and inducing a series of gene expressions.Besides,bioeffects of physical stimulations combined with bone scaffolds which fabricated using 3D printing technology on bone cells were discussed.The equipments of physical stimulation system were described.The opportunities and challenges of physical stimulations were also presented from the perspective of bone repair. | Cijun Shuai Wenjing Yang Shuping Peng Chengde Gao Wang Guo Yuxiao Lai Pei Feng | 2018 | International Journal of Bioprinting2018，4，2： | 3 |
| 7 | Apparent ages of suspended sediment and soil erosion of the Pearl River (Zhujiang) drainage basin显示文摘The carbon isotopic composition (Δ 14 C,δ 13 C) and apparent ages of suspended sediment were determined in the Pearl River in the years 1998,2000 and 2005.These results indicate that suspended POC consists mostly of young carbon and some 'old carbon'.Apparent ages of suspended POC range from 540 to 2050 a BP.The apparent ages are older in the Xijiang and Beijiang Rivers,while these values are variable in the Dongjiang River,including old and young samples.The suspended POCδ 13 C values increase with increasing Δ 14 C in the Pearl River,indicating that its source is soil and bedrock from depths under 15 30 cm.Since the organic carbon of the surface soil is quickly decomposed when it enters the rivers,its carbon isotopic characteristics are insignificant in suspended sediment.In the Pearl River drainage basin,there are areas with more severe soil erosion than others.For example,erosion is much more severe in the Xijiang River drainage basin when compared to the light soil erosion in the Dongjiang River drainage basin. | WEI XiuGuo SHEN ChengDe LI NingLi WANG FuShun DING Ping WANG Ning GUO ZhiXing LIU KeXin | 2010 | Chinese Science Bulletin2010，55，15： | 2 |
| 8 | Mechanism for corrosion protection of β-TCP reinforced ZK60 via laser rapid solidification显示文摘It remains the primary issue to enhance the corrosion resistance of Mg alloys for their clinical applications.In this study,β-tricalcium phosphate(β-TCP)was composited with Mg-6Zn-1Zr(ZK60)using laser rapid solidification to improve the degradation behavior.Results revealed rapid solidification effectively restrained the aggregation ofβ-TCP,which thus homogenously distributed along grain boundaries ofα-Mg.Significantly,the uniformly distributedβ-TCP in the matrix promoted the formation of apatite layer on the surface,which contributed to the formation of a compact corrosion product layer,hence retarding the further degradation.Furthermore,ZK60/8β-TCP(wt.%)composite showed improved mechanical strength,as well as improved cytocompatibility.It was suggested that laser rapidly solidified ZK60/8β-TCP composite might be a potential materials for tissue engineering. | Youwen Deng Youwen Yang Chengde Gao Pei Feng Wang Guo Chongxian He Jian Chen Cijun Shuai | 2018 | International Journal of Bioprinting2018，4，1： | 2 |
| 9 | ~4C as a tool for evaluating riverine POC sources and erosion of the Zhujiang (Pearl River) drainage basin, South China 显示文摘 | Wei Xiuguo Yi Weixi Shen Chengde Yechieli Y Li Ningli Ding Ping Wang Ning Liu Kexin | 2010 | Nucl Instrum Methods Phys Res Sect B2010，268，7： | 1 |
| 10 | Elastic solutions for a transversely isotropic half-space subjected to buried asymmetric-Ioads 显示文摘 | Wang Chengde | 1999 | International Jour-nal for Numerical and Analytical Methods in Geomechanics1999，23，2： | 1 |
| 11 | An nMgO containing scaffold:Antibacterial activity,degradation properties and cell responses显示文摘Bone repair failure caused by implant-related infections is a common and troublesome problem.In this study,an antibacterial scaffold was developed via selective laser sintering with incorporating nano magnesium oxide(nMgO)to poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV).The results indicated the scaffold exerted high antibacterial activity.The antibacterial mechanism was that nMgO could cause oxidative damage and mechanical damage to bacteria through the production of reactive oxygen species(ROS)and direct contact action,respectively,which resulted in the damage of their structures and functions.Besides,nMgO significantly increased the compressive properties of the scaffold including strength and modulus,due to its excellent mechanical properties and uniform dispersion in the PHBV matrix.Moreover,the degradation tests indicated nMgO neutralized the acid degradation products of PHBV and benefited the degradation of the scaffold.The cell culture demonstrated that nMgO promoted the cellular adhesion and proliferation,as well as osteogenic differentiation.The present work may open the door to exploring nMgO as a promising antibacterial material for tissue engineering. | Cijun Shuai Wang Guo Chengde Gao Youwen Yang Ping Wu Pei Feng | 2018 | International Journal of Bioprinting2018，4，1： | 1 |
| 12 | Additive manufacturing of bone scaffolds显示文摘Additive manufacturing(AM)can obtain not only customized external shape but also porous internal structure for scaffolds,both of which are of great importance for repairing large segmental bone defects.The scaffold fabrication process generally involves scaffold design,AM,and post-treatments.Thus,this article firstly reviews the state-of-the-art of scaffold design,including computer-aided design,reverse modeling,topology optimization,and mathematical modeling.In addition,the current characteristics of several typical AM techniques,including selective laser sintering,fused deposition modeling(FDM),and electron beam melting(EBM),especially their advantages and limitations are presented.In particular,selective laser sintering is able to obtain scaffolds with nanoscale grains,due to its high heating rate and a short holding time.However,this character usually results in insufficient densification.FDM can fabricate scaffolds with a relative high accuracy of pore structure but with a relative low mechanical strength.EBM with a high beam-material coupling efficiency can process high melting point metals,but it exhibits a low-resolution and poor surface quality.Furthermore,the common post-treatments,with main focus on heat and surface treatments,which are applied to improve the comprehensive performance are also discussed.Finally,this review also discusses the future directions for AM scaffolds for bone tissue engineering. | Youwen Yang Guoyong Wang Huixin Liang Chengde Gao Shuping Peng Lida Shen Cijun Shuai | 2019 | International Journal of Bioprinting2019，5，1： | 1 |
| 13 | Ecological Benefits of Compound Ridge Culture in Hillside Orchard in the Three Gorge Reservoir Area显示文摘Based on contour tillage of wide ridge and furrow covering and agro-forestry, this paper sets up a compound ridge culture mode in hillside orchards and introduces a long-term observation to the mode's effects on ecological benefits of water and soil conservation. A five-year study shows that compound ridge culture in hillside orchards is effective in water and soil conservation, especially in reducing soil erosion. Compared with the traditional management modes of orchards, compound ridge culture has reduced runoff amount by 41.96%-57.96%, soil erosion amount by 55.47%-67.75%. Compound ridge culture also brings an obvious reduction of soil nutrient loss and of non-point source pollution, which is of great importance for keeping and increasing the productivity of hillside orchards in the Three Gorge Reservoir Area. | LIAO Xiaoyong CHEN Zhijian WANG Haiming LUO Chengde LI Tao | 2008 | Wuhan University Journal of Natural Sciences2008，13，3： | 1 |
| 14 | Elastic Solutions for a Transversely Isotropic Half-space Subjected to Buried Asymmetric-loads显示文摘 | Wang Chengde | 1999 | In-ternational Journal for Numerical and Analytical Methods in Geomechanics1999，23，2： | 1 |
| 15 | Two-photo Microstructurepolymerization Initiated by a Coumarin Derivative/iodonium Salt System 显示文摘 | Chengde Li Le Luo Shufeng Wang | 2001 | Chemical Physics Letter2001，340，： | 1 |
| 16 | Elastic solutions for a transversely iso- tropic half-space subjected to a point load显示文摘 | WANG Chengde | 1998 | International Jour- nal for Numerical and Analytical Methods in Geomechanics1998，22，42： | 1 |
| 17 | Modification of Norditerpenoid Alkaloids:Ⅱ.A Simple andConvenient Preparation of the Imine Derivatives of Norditerpenoid Alkaloids显示文摘Treatment of 3-acetylpseudaconie 6 and 3. 13-diacetylyunnaconitine 9 withNBS/acetone-H2O(2:1) at room temperature produced corresponding imine derivatives & and 10.respectively. in good yields. This is a novel simple and convenient method for preparation of theimine compounds. | Feng Peng WANG Zheng Bang LI Jin Song YANG and Bo Gang LI(Department of Chemistry of Medicinal Natural Products School of PharmacyWest China University of Medical Sciences. Chengdu 610041 Chengdu Institute of Biology. Chinese Academy of Sciences. Chengd | 1999 | Chinese Chemical Letters1999，10，6： | 1 |
| 18 | Improved robust stability criteria for delayedcellular neural networks via the LMI approach 显示文摘 | Zheng Chengde Zhang Huaguang Wang Zhans-han | 2010 | IEEE Trans Circuits and Systems II2010，57，1： | 1 |
| 19 | A multi-scale porous scaffold fabricated by a combined additive manufacturing and chemical etching process for bone tissue engineering显示文摘It is critical to develop a fabrication technology for precisely controlling an interconnected porous structure of scaffolds to mimic the native bone microenvironment.In this work,a novel combined process of additive manufacturing(AM)and chemical etching was developed to fabricate graphene oxide/poly(L-lactic acid)(GO/PLLA)scaffolds with multiscale porous structure.Specially,AM was used to fabricate an interconnected porous network with pore sizes of hundreds of microns.And the chemical etching in sodium hydroxide solution constructed pores with several microns or even smaller on scaffolds surface.The degradation period of the scaffolds was adjustable via controlling the size and quantity of pores.Moreover,the scaffolds exhibited surprising bioactivity after chemical etching,which was ascribed to the formed polar groups on scaffolds surfaces.Furthermore,GO improved the mechanical strength of the scaffolds. | Cijun Shuai Youwen Yang Pei Feng Shuping Peng Wang Guo Anjie Min Chengde Gao | 2018 | International Journal of Bioprinting2018，4，2： | 1 |
| 20 | Two-photon microstructure-polymerization initiated by a coumarin derivative/iodonium salt system显示文摘 | Li chengde Luo Le Wang Shufeng | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员