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| 1 | Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia. | Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng | 2015 | World Journal of Gastroenterology2015，21，42： | 2 |
| 2 | Application of soft landing to the process control of chemical mechanical polishing显示文摘 | Chiu J B Yu C C Shen S H | 2003 | Microelectronic Engineering2003，65，3： | 2 |
| 3 | “Trends” and variations of global oceanic evaporation data sets from remote sensing显示文摘The variability in global oceanic evaporation data sets was examined for the period 1988-2000.These data sets are satellite estimates based on bulk aerodynamic formulations and include the NASA/Goddard Space Flight Center Satellite-based Surface Turbulent Flux version 2(GSSTF2),the Japanese-ocean flux using remote sensing observations(J-OFURO),and the Hamburg Ocean-Atmosphere Parameters and Fluxes from Satellite version 2(HOAPS2).The National Center for Environmental Prediction(NCEP)reanalysis is also included for comparison.An increase in global average surface latent heat flux(SLHF)can be observed in all the data sets.Empirical mode decomposition(EMD)shows long-term increases that started around 1990 for all remote sensing data sets.The effect of Mt.Pinatubo eruption in 1991 is clearly evident in HOAPS2 but is independent of the long-term increase.Linear regression analyses show increases of 9.4%,13.0%,7.3%,and 3.9% for GSSTF2,J-OFURO,HOAPS2 and NCEP,for the periods of the data sets.Empirical orthogonal function(EOF)analyses show that the pattern of the first EOF of all data sets is consistent with a decadal variation associated with the enhancement of the tropical Hadley circulation,which is supported by other satellite observations.The second EOF of all four data sets is an ENSO mode,and the correlations between their time series and an SOI are 0.74,0.71,0.59,and 0.61 for GSSTF2,J-OFURO,HOAPS2,and NCEP in that order.When the Hadley modes are removed from the remote sensing data,the residue global increases are reduced to 2.2%,7.3%,and <1% for GSSTF2,J-OFURO and HOAPS,respectively.If the ENSO mode is used as a calibration standard for the data sets,the Hadley mode is at least comparable to,if not larger than,the ENSO mode during our study period. | CHIU Long S CHOKNGAMWONG R XING Yukun YANG Ruixin SHIE Chung-Lin | 2008 | Acta Oceanologica Sinica2008，27，3： | 2 |
| 4 | Antipsychotic Medications in Major Depression and the Association with Treatment Satisfaction and Quality of Life: Findings of Three National Surveys on Use of Psychotropics in China Between 2002 and 2012显示文摘 | Yu-Xi Wang Yu-Tao Xiang Yun-Ai Su Qian Li Liang Shu Chee H Ng Gabor S Ungvari Helen FK Chiu Yu-Ping Nin Gao-Hua Wang Pei-Shen Bai Tao Li Li-Zhong Sun Jian-Guo Shi Xian-Sheng Chen Qi-Yi Mei Ke-Qing Li Xin Yu Tian-Mei Si | 2015 | Chinese Medical Journal2015，，14： | 2 |
| 5 | Effects of the phase-separated melt on crystallization behavior and morphology in short chain branched metallocene polyethylenes显示文摘 | Fu Q Chiu F C McCreight K W Guo M Tseng W W Cheng S Z Keating M Y Hsieh E T and DesLauriers P J | | 0，，： | 2 |
| 6 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 7 | Fuzzy Model Identification Based on Ouster Estimation显示文摘 | Chiu S L | 1994 | Journal of Intelligent and Fuzzy Systems1994，2，3： | 1 |
| 8 | Preparation and characterization of urease immobilized onto porous chitosan beads for urea hydrolysis显示文摘 | Chiu S H | 1999 | Bioprocess Engeneering1999，21，： | 1 |
| 9 | Origin of Field-Dependent Optical Transmission of Magnetic Fluid Films显示文摘 | Chiu Y P Jeang B Y | 2001 | Applied Physics Letters2001，79，： | 1 |
| 10 | Accumulation of nutrients and heavy metals in surface sediments near Macau 显示文摘 | Ferreira F M Chiu W S Cheok H K etal | 1996 | Marine Pollution Bulletin1996，32，5： | 1 |
| 11 | Computed tomography angiography imaging for the chimeric anterolateral thigh flap in reconstruction of full thickness buccal defect显示文摘 | CHIU W K LIN W C CHEN S Y | 2011 | ANZ J Surg2011，81，3： | 1 |
| 12 | Fuzzy model identification based on cluster estimation显示文摘 | CHIU S L | 1994 | Journal of lnteUigent and Fuzzy Systems1994，2，3： | 1 |
| 13 | A near-optimal sensor placement algorithm to achieve complete coverage/discrimination in sensor networks显示文摘 | F Y S Lin P L Chiu | 2005 | IEEE Communications Letters2005，9，1： | 1 |
| 14 | In vitro neutralization by monoclonal antibodies against yellow grouper nervous necrosis virus(YGNNV) and immunolocalization of viru infection in yellow grouper,Epinephelus awoara (Temminck & Schlegel)显示文摘 | Lai Y S Chiu H C Murali S | 2001 | J Fish Dis2001，24，： | 1 |
| 15 | Subcutaneous fat necrosis of the newhom complicating hypothermic cardiac surgery 显示文摘 | CHUANG S D CHIU H C CHANO C C | 1995 | Br J Dermatol1995，132，5： | 1 |
| 16 | Volume fractions of silver-coated copper powders in conductive adhesives for microelectronic applications 显示文摘 | LIN Y S CHIU S S | 2004 | Polym Eng Sci2004，44，11： | 1 |
| 17 | A sensitive and robust method for the determination of alkylphenol polyethoxylates and their carboxylic acids and their transformation in a trickling filter wastewater treatment plant显示文摘 | Koh Y K K Chiu T Y Boobis A R Cartmell E Pollard S J T Scrimshaw M D I_ester J N | 2008 | Chemosphere2008，73，4： | 1 |
| 18 | Emergy- based fuzzy optimization approach for water reuse in an eco-industrial park 显示文摘 | MOHAMMAD SADEGH TASKHIRI TAN R R CHIU A S F | 2011 | Resources Conservation and Recycling2011，55，： | 1 |
| 19 | Effects of a chinesemedical herbs complex on cellular immunity and toxicityrelatedconditions of breast cancer patients显示文摘 | ZHUANG S R CHIU H F CHEN S l | 2012 | The British Journal of Nutrition2012，107，14： | 1 |
| 20 | High-performance film bulk acoustic wave pressure and temperature sensors显示文摘 | Chiu K H Chen H R Huang S R S | 2007 | JapaneseJournal of Applied Physics2007，46，4： | 1 |
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