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| 1 | Identification of the Mamestra configurata (Lepidoptera Noctuidae) peritrophic matrix proteins and enzymes involved in peritrophic matrix chitin metabolism显示文摘peritrophic 矩阵(下午) 为昆虫是必要的它由食物粒子,病原体,和毒素保护 midgut 上皮免受损坏的伤害的消化系统生理学。下午也由于它的 per os 可接近性是为新害虫控制策略的开发的一个吸引人的目标。理解 PM 怎么执行这些函数, PM 的分子的体系结构用 genomic 被检验, proteomic 在 Mamestra configurata 来临(鳞翅目:Noctuidae ) ,饰有十字架的 oilseed 的一个主要害虫在北美洲收割。PM 的液体层析双人脚踏车团 spectrometry 分析识别了是分类的 82 蛋白质:(i) peritrophins,与一个 CBDIII 领域包括一个新班;(ii ) 酶在几丁质修正(几丁质 deacetylases ) 包含了,消化(丝氨酸朊酶, aminopeptidases, carboxypeptidases,脂肪分解酵素和 α-amylase ) 或另外的反应(β-1,3-glucanase,碱的磷酸酶, dsRNase,虾红素, pantetheinase ) ;(iii ) 没有已知的 orthologs,由 polycalin, REPAT, serpin, C 类型 lectin 和 Lsti99/Lsti201 和 3 新奇蛋白质组成的一个异质的组。编码下午蛋白质的基因在 midgut 主要被表示。cDNAs 编码几丁质 synthase-2 (McCHS-2 ) , chitinase (McCHI ) ,和 β-N-acetylglucosaminidase (McNAG ) 酶,在下午几丁质新陈代谢包含了,也被识别。McCHS-2 表示对显示它为在 PM,的几丁质合成负责的 midgut 特定在 midgut 的唯一的几丁质的材料。相反,编码 chitinolytic 酶的基因在多重纸巾被表示。McCHS-2, McCHI,和 McNAG 在喂幼虫的 midgut 被表示,并且唠叨活动在 PM 是在场的。这个信息被用来产生鳞翅类的下午建筑学的一个更新的模型。 | Umut Toprak Martin Erlandson Doug Baldwin Steve Karcz Lianglu Wan Cathy Coutu Cedric Gillott Dwayne D. Hegedus | 2016 | Insect Science2016，23，5： | 4 |
| 2 | How resilience works 显示文摘 | Coutu D L | 2002 | Harvard Business Review2002，80，： | 1 |
| 3 | Natural history and treated course of usual and desquamative interstitial pneumonia显示文摘 | Carrington CB Gaensler EA Coutu RE | 1978 | N Engl J Med1978，298，15： | 1 |
| 4 | Atrial fibrillation-associated minK38G/S polymorphism modulates delayed rectifier current and membrane localization显示文摘 | Ehrlich JR Zicha S Coutu P | 2005 | Cardiovas Res2005，67，3： | 1 |
| 5 | Atrial fibrillation-asso- ciated MinK38G/S polymorphism modulates delayed rectifier current and membrane localization 显示文摘 | Ehrlieh JR Zicha S Coutu P | 2005 | Cardiovasc Res2005，67，3： | 1 |
| 6 | The zinc-finger protein Zatl2 plays a central role in reactive oxygen and abiotie stress signaling in Arabidopsis显示文摘 | Davletova S Schlaueh K Coutu J | 2005 | Plant Physiol2005，139，2： | 1 |
| 7 | Proteomics analysis of Trichoplusia ni midgut epithelial cell brush border membrane vesicles显示文摘The insect midgut epithelium is composed of columnar, goblet, and regenerative cells. Columnar epithelial cells are the most abundant and have membrane protrusions that form the brush border membrane (BBM) on their apical side. These increase surface area available for the transport of nutrients, but also provide opportunities for interaction with xenobiotics such as pathogens, toxins and host plant allelochemicals. Recent improvements in proteomic and bioinfbrmatics tools provided an opportunity to determine the proteome of the T. ni BBM in unprecedented detail. This study reports the identification of proteins from BBM vesicles (BBMVs) using single dimension polyacrylamide gel elec? trophoresis coupled with multi-dimensional protein identification technology. More than 3000 proteins were associated with the BBMV of which 697 were predicted to possess either a signal peptide, at least one transmembrane domain or a GPI-anchor signal. Of these, bioinfbrmatics analysis and manual curation predicted that 185 may be associated with the BBMV or epithelial cell plasma membrane. These are discussed with respect to their predicted functions, namely digestion, nutrient uptake, cell signaling, development, cell-cell interactions, and other functions. We believe this to be the most detailed proteomic analysis of the lepidopteran midgut epithelium membrane to date, which will provide information to better understand the biochemical, physiological and pathological processes taking place in the larval midgut. | Muhammad Afzal Javed Cathy Coutu David A. Theilmann Martin A. Erlandson Dwayne D. Hegedus | 2019 | Insect Science2019，26，3： | 1 |
| 8 | Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure显示文摘 | White DE Coutu P Shi YF | 2006 | Genes Dev2006，20，17： | 1 |
| 9 | A three-dimensional ring annuloplasty for the treatment of tricuspid regurgitation显示文摘 | Salzberg SP Coutu M | 2006 | Ann Thorac Surg2006，81，6： | 1 |
| 10 | A three-dimensional ring annuloplasty for the treatment of tricuspid regurgitation 显示文摘 | Filsoufi F Salzerg SP Coutu M | 2006 | Ann Thorac Surg2006，81，6： | 1 |
| 11 | Atrial fibrillation- asso- ciated minK38G/S polymorphism modulates delayed rectifier current and membrane localization 显示文摘 | Ehrlich JR Zicha S Coutu P | 2005 | Cardiovasc Res2005，67，3： | 1 |
| 12 | Metabolite profiling study of propranolol in rat using LC/MS/MS analysis显示文摘 | Beaudry F Le Blanc JCY Coutu M | 1999 | Biomed Chromatogr1999，13，： | 1 |
| 13 | Bifurcation analysis of a predatorprey system with generalised Holling type Ⅲ functional response显示文摘 | Lamontagne Y Coutu C Rousseau C | 2008 | Journal of Dynamics and Differential Equations2008，20，3： | 1 |
| 14 | Periostin,a member of a novel family of vitam in K-dependent proteins is expressed by mesenchymal stromal cells显示文摘 | Coutu DL Wu JH Monette A | 2008 | J Biol Chem2008，283，17： | 1 |
| 15 | Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure 显示文摘 | White D E Coutu P Shi Y F | 2006 | Genes Dev2006，20，17： | 1 |
| 16 | Needs and anxiety levels in relatives of intensive care unit patients显示文摘 | Rukholm E Bailey P Coutu WG | 1991 | Journal of Advanced Nursing1991，16，： | 1 |
| 17 | Cytosolic ascorbate peroxidase 1 is a central component of the reactive oxygen gene network of Arabidopsis 显示文摘 | Davletova S Rizhsky L Liang H Shengqiang Z 0liver D J Coutu J Shulaev V Schlauch K Mittler R | 2005 | Plant Cell2005，17，： | 1 |
| 18 | Mechanisms un- derlying rate - dependent remodeling of transient outward potassi- um current in canine ventricularmyocytes 显示文摘 | XIAO L COUTU P VILLENEUVE L R | 2008 | Circ Res2008，103，7： | 1 |
| 19 | Roles of FGF signaling in stem cell self-renew- al, senescence and aging 显示文摘 | Coutu DL Galipeau J | 2011 | Aging ( Albany NY )2011，3，10： | 1 |
| 20 | Mechanisms underlying rate- dependent remodeling of transient outward potassium current in canine ventricular myocytes 显示文摘 | Xiao L Coutu P Villeneuve L R | 2008 | Circ Res2008，103，7： | 1 |
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