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| 1 | Regulation of the G1 phase of the mammalian cell cycle显示文摘In any multi-cellular organism, the balance between cell division and cell death maintains a constant cell number. Both cell division cycle and cell death are highly regulated events. Whether the cell will proceed through the cycle or not, depends upon whether the conditions required at the checkpoints during the cycle are fulfilled. In higher eucaryotic cells, such as mammalian cells, signals that arrest the cycle usually act at a G1 checkpoint. Cells that pass this restriction point are committed to complete the cycle. Regulation of the GI phase of the cell cycle is extremely complex and involves many different families of proteins such as retinoblastoma family cyclin dependent kinases, cyclins, and cyclic kinase inhibitors. | DONJERKOVIC DUBRRAVKA DAVID W SCOTT (Department of Immunology, Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD) | 2000 | Cell Research2000，10，1： | 18 |
| 2 | Antidiabetic thiazolidinediones induce ductal differentiation but not apoptosis in pancreatic cancer cells显示文摘AIM: Thiazolidinediones (TZD) are a new class of oral antidiabetic drugs that have been shown to inhibit growth of same epithelial cancer cells. Although TZD were found to be ligands for peroxisome proliferator-activated receptor γ (PPARγ), the mechanism by which TZD exert their anticancer effect is presently unclear. In this study,we analyzed the mechanism by which TZD inhibit growth of human pancreatic carcinoma cell lines in order to evaluate the potential therapeutic use of these drugs in pancreatic adenocarcinoma.METHODS: The effects of TZD in pancreatic cancer cells were assessed in anchorage-independent growth assay.Expression of PPARγ was measured by reverse-transcription polymerase chain reaction and confirmed by Western blot analysis. PPARγ activity was evaluated by transient reporter gene assay. Flow cytometry and DNA fragmentationassay were used to determine the effect of TZD on cell cycle progression and apoptosis respectively. The effect of TZD on ductal differentiation markers was performed by Western blot.RESULTS: Exposure to TZD inhibited colony formation in a PPARγ-dependent manner. Growth inhibition was linked to G1 phase cell cycle arrest through induction of the ductal differentiation program without any increase of the apoptotic rate.CONCLUSION: TZD treatment in pancreatic cancer cells has potent inhibitory effects on growth by a PPAR-dependent induction of pacreatic ductal differentiation. | Elisabetta Ceni Tommaso Mello Mirko Tarocchi David W Crabb Anna Caldini Pietro Invernizzi Calogero Surrenti Stefano Milani Andrea Galli | 2005 | World Journal of Gastroenterology2005，11，8： | 15 |
| 3 | Activation-induced cell death in B lymphocytes显示文摘Upon encountering the antigen (Ag), the immune system can either develop a specific immune response or enter a specific state of unresponsiveness, tolerance. The response of B cells to their specific Ag can be activation and proliferation, leading to the immune response, or anergy and activation-induced cell death (AICD), leading to tolerance. AICD in B lymphocytes is a highly regulated event initiated by crosslinking of the B cell receptor (BCR). BCR engagement initiates several signaling events such as activation of PLCr, Ras, and PI3K, which generally speaking, lead to survival. However, in the absence of survival signals (CD40 or IL-4R engagement), BCR crosslinking can also promote apoptotic signal transduction pathways such as activation of effector caspases, expression of pro-apoptotic genes, and inhibition of pro-survival genes. The complex interplay between survival and death signals determines the B cell fate and, consequently, the immune response. | DONJERKOVIC DUBRAVKA, DAVID W SCOTT (Department of Immunology, Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD, 20855. USA) | 2000 | Cell Research2000，10，3： | 6 |
| 4 | Enrichment analysis of Alu elements with different spatial chromatin proximity in the human genome显示文摘Transposable 元素(TE ) 完全不再在相当一时间被看作了垃圾 DNA 自从他们在优核质染色体的多功能的角色的不断的发现。作为最重要、丰富的 TE 之一在人的染色体仍然活跃,算术逻辑单元,一个正弦家庭,证明了它在顺序水平的不可缺少的规章的功能,而是它的空间角色仍然是不清楚的。技术基于 3C (染色体符合构造俘获) 揭示了染色质的神秘三维的结构,并且使在染色体学习远侧的染色质相互作用可能。发现角色 TE 在人的染色体在远侧的规定玩,我们编了新释放 Hi-C 数据, TE 注解, histone 标记注解,和操作关联分析的染色体宽的 methylation 数据,并且发现算术逻辑单元元素的密度与染色质相互作用的水平显示出强壮的积极关联( hESC :r = 0.9, P < 2.2 在 IC 的限制体积。我们以 anisotropy 解释观察并且对几检查 anisotropy 为哪个剩余散布的试穿被发现有能力的很少建模。我们特别地确定蘸的断绝把 IC 的充分各向同性的房顶与它的各向异性的身体分开的模型,而 isotropy-anisotropy 转变的深度从 190 在东南方向增加 ? 在东南的亚洲下面的 km (离开中国的海岸) 到 350 ? 在澳大利亚下面的 km。如果,以局部性的各向异性的异质扔的另一个可接受的模型是有效的在光线采样上的 33 最大的极的大小在东南的亚洲和极的数据的其余部分下面的小体积独立被对待。这个模型在至少下面想象 IC 的几乎各向同性的东方半球到 360 的深度 ? 在 ICB 下面的 km 并且从 18 仅仅抑制各向异性的体积到诺思纬度的范围 ? 敪湵獥吗?? | Zhuoya Gu Ke Jin M. James C. Crabbe Yang Zhang Xiaolin Liu Yanyan Huang Mengyi Hua Peng Nan Zhaolei Zhang Yang Zhong | 2016 | Protein & Cell2016，7，4： | 4 |
| 5 | Discovery of a high-altitude ecotype and ancient lineage of Arabidopsis thaliana from Tibet显示文摘Arabidopsis thaliana(A.thaliana)has long been a model species for dicotyledon study,and was the first flowering plant to get its genome completed sequenced[1].Although most wild A.thaliana are collected in Europe,several studies have found a rapid A.thaliana west-east expansion from Central Asia[2].The Qinghai-Tibet Plateau(QTP)is close to Central Asia and known for its high alti- | Liyan Zeng Zhuoya Gu Min Xu Ning Zhao Weidong Zhu Takahiro Yonezawa Tianmeng Liu Lha Qiong Tashi Tersing Lingli Xu Yang Zhang Rongyan Xu Ningyu Sun Yanyan Huang Jiankun Lei Liang Zhang Feng Xie Fang Zhang Hongya Gu Yupeng Geng Masami Hasegawa Ziheng Yang M. James C. Crabbe Fan Chen Yang Zhong | 2017 | Science Bulletin2017，62，24： | 3 |
| 6 | Utility of point-of-care musculoskeletal ultrasound in the evaluation of emergency department musculoskeletal pathology显示文摘BACKGROUND: To evaluate the utilization of point-of-care ultrasound(POCUS) for the assessment of emergency department(ED) patients with musculoskeletal symptoms and the impact of musculoskeletal POCUS on medical decision-making and patient management in the ED.METHODS: This was a retrospective review of ED patients presenting with musculoskeletal symptoms who received a POCUS over a 3.5-year period. An ED POCUS database was reviewed for musculoskeletal POCUS examinations used for medical decision-making. Electronic medical records were then reviewed for demographic characteristics, history, physical examination findings, ED course, additional imaging studies, and impact of musculoskeletal POCUS on patient management in ED. RESULTS: A total of 264 subjects(92 females, 172 males) and 292 musculoskeletal POCUS examinations were included in the fi nal analysis. Most common symptomatic sites were knee(31.8%) and ankle(16.3%). Joint effusion was the most common fi nding on musculoskeletal POCUS, noted in 33.7% of the patients, and subcutaneous edema/cobblestoning was found in 10.2% of the patients. Muscle or tendon rupture was found in 2.3% of the patients, and 1.9% of the patients had joint dislocation. Bursitis or bursa fluid was found in 3.4% of patients, and tendonitis/tendinopathy was found in 2.3%. Twenty percent of them were ultrasound-guided musculoskeletal procedures, and most of them(73.3%) were arthrocentesis. Of the included studies, all except three either changed or helped guide patient management as documented in the patients' medical records.CONCLUSION: Our study fi ndings illustrate the utility of POCUS in the evaluation of a variety of musculoskeletal pathologies in the ED. | Elaine Situ-LaCasse Ryan W. Grieger Stephen Crabbe Anna L. Waterbrook Lucas Friedman Srikar Adhikari | 2018 | World Journal of Emergency Medicine2018，9，4： | 3 |
| 7 | Chymosin and aspartic proteinases显示文摘 | CHITPINITYOL CRABBE | 1998 | Food Chemistry1998，61，： | 2 |
| 8 | The α_Mβ_2 integrin and its role in neutrophil function显示文摘Neutrophils are the first cell type to arrive at the in-jury sites and play a critical role in host defense, by virtueof its ability to adhere and transmigrate through endothe-lium, to phagocytose foreign pathogens, and to producefree oxygen radicals and proteolytic enzymes. Yet, inap-propriate neutrophil activation causes tissue damage andvarious inflammatory diseases. These physiological andpathological functions of neutrophils depend on the en-gagement of certain surface receptors, especially αMβ2,the ma jor β2 integrin receptor present on neutrophil sur-face. Understanding of the molecular mechanisms under-lying ligand binding by αMβ2, as well as the roles of αMβ2-ligand interactions in neutrophil functions will enable usto regulate more precisely neutrophil activities: that is,to promote their host defense functions, and at the sametime to minimize their deleterious effects on normal cells. | ZHANG LI (Department of Vascular Biology, American Red Cross,Holland La6oratory, 15601 Crabbs Branch Way, Rockville,MD 20855 USA)Tel: 301-738-0657 Fax: 301-738-0465e-mail: zhangl@u8a.redcross. org | 1999 | Cell Research1999，9，3： | 2 |
| 9 | Acetaldehyde Inhibits PPARγ via H 2 O 2 -Mediated c-Abl Activation in Human Hepatic Stellate Cells显示文摘 | Elisabetta Ceni David W. Crabb Marco Foschi Tommaso Mello Mirko Tarocchi Valentino Patussi Luca Moraldi Renato Moretti Stefano Milani Calogero Surrenti Andrea Galli | 2006 | Gastroenterology2006，，4： | 2 |
| 10 | Extension of impact-ionization multiplication coefficient measurements to high electric fields in advanced Si BJT's显示文摘 | Zanoni E Crabbe E F | 1993 | IEEE Elec Dev Lett1993，14，2： | 2 |
| 11 | The Role of Lipid Metabolism in the Pathogenesis of Alcoholic and Nonalcoholic Hepatic Steatosis显示文摘 | Margaret Sozio Suthat Liangpunsakul David Crabb | 2010 | Semin Liver Dis2010，，04： | 2 |
| 12 | Differential action of angiotensin Ⅱ and activity of angiotensin - converting enzyme in human bypass grafts显示文摘 | Borland JA Chester AH Crabbe S | 1998 | J Thorac Cardiovasc Surg1998，116，2： | 2 |
| 13 | Assessment of genetic susceptibility to ethanol intoxication in mice 显示文摘 | Rustay NR Wahlsten D Crabbe JC | 2003 | Proc Natl Acad Sci USA2003，100，5： | 1 |
| 14 | Biodiesel production from crude palm oil and evaluation of butanol extraction and fuel properties显示文摘 | CRABBE E NOLASCO - HIPOLITO C KOBAYASHI G | 2001 | Process Biochem2001，37，1： | 1 |
| 15 | Prediction of groundborne vibration from vibrating rollers显示文摘 | Crabb G I Hiller D M | 2002 | Transport2002，153，2： | 1 |
| 16 | Chymosin and aspartic proteinases显示文摘 | CHITPINITYOL S M CRABBE M J C | 1998 | Food Chem1998，61，4： | 1 |
| 17 | Morphology and kinetics of the three distinct phases of red blood cell invasion by Plasmodium falciparum merozoites显示文摘 | Gilson PR Crabb BS | 2009 | International Journal for Parasitology2009，39，1： | 1 |
| 18 | Ethanol oxidizing enzymes: roles in alcohol metabohsm and alcoholic liver disease显示文摘 | Crabb DW | 1995 | Prog Liver Dis1995，，13： | 1 |
| 19 | Magnetic resonance imaging of the wrist in rheumatoid arthritis:demonstration of progression between 1 and 6 years显示文摘 | Stewart NR Crabbe JP McQueen FM | 2004 | Skeletal Radiol2004，33，12： | 1 |
| 20 | Biological markers for increased risk of alcoholism and for quantitation of alcohol consumption显示文摘 | Crabb D W | 1990 | J Clin Invest1990，85，2： | 1 |
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