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| 1 | Hepatic abscess induced by foreign body:Case report and literature review显示文摘Hepatic abscess due to perforation of the gastrointestinal tract caused by ingested foreign bodies is uncommon. Pre-operative diagnosis is difficult as patients are often unaware of the foreign body ingestion and symptoms and imagiology are usually non-specific. The authors report a case of 62-year-old woman who was admitted with fever and abdominal pain. Further investigation revealed hepatic abscess, without resolution despite antibiotic therapy. A liver abscess resulting from perforation and intra-hepatic migration of a bone coming from the pilorum was diagnosed by surgery. The literature concerning foreign body-induced perforation of the gastrointestinal tract complicated by liver abscess is reviewed. | Sofia A Santos Sara CF Alberto Elsa Cruz Eduardo Pires Tomás Figueira lia Coimbra José Estevez Mário Oliveira Luís Novais Joo R Deus | 2007 | World Journal of Gastroenterology2007，13，9： | 10 |
| 2 | Treatment of chronic hepatitis C with direct-acting antivirals: The role of resistance显示文摘The use of direct-acting antivirals(DAAs) to treat chronic hepatitis C has resulted in a significant increase in rates of sustained viral response(around 90%-95%) as compared with the standard treatment of peginterferon/ribavirin. Despite this, however, the rates of therapeutic failure in daily clinical practice range from 10%-15%. Most of these cases are due to the presence of resistant viral variants, resulting from mutations produced by substitutions of amino acids in the viral target protein that reduce viral sensitivity to DAAs, thus limiting the efficacy of these drugs. The high genetic diversity of hepatitis C virus has resulted in the existence of resistance-associated variants(RAVs), sometimes even before starting treatment with DAAs, though generally at low levels. These preexisting RAVs do not appear to impact on the sustained viral response, whereas those that appear after DAA therapy could well be determinant in virological failure with future treatments. As well as the presence of RAVs, virological failure to treatment with DAAs is generally associated with other factors related with a poor response, such as the degree of fibrosis, the response to previous therapy, the viral load or the viral genotype. Nonetheless, viral breakthrough and relapse can still occur in the absence of detectable RAVs and after the use of highly effective DAAs, so that the true clinical impact of the presence of RAVs in therapeutic failure remains to be determined. | Miguel Jiménez-Pérez Rocío González-Grande Pilar Espana Contreras Isabel Pinazo Martínez Jesús de la Cruz Lombardo Raúl Olmedo Martín | 2016 | World Journal of Gastroenterology2016，22，29： | 3 |
| 3 | Performance and yield stability of maize hybrids in stress-prone environments in eastern Africa显示文摘Identification and deployment of high-yielding and stress-tolerant maize hybrids adapted to stress-prone agro-ecologies is important for improving the food security and livelihoods of smallholder farmers in eastern Africa.The objectives of this study were to(i)assess the performance of maize hybrids under well-watered and drought stress conditions;(ii)evaluate grain yield stability of 65 intermediate-maturing and 55 early-maturing hybrids in 24 well-watered locations and seven drought stress locations;and(iii)identify representative and/or discriminative testing locations for increasing genetic gains for the target traits.There were significant differences for grain yield among early-and intermediatematuring hybrids tested under well-watered and drought stress environments.Among the early-maturing hybrids,the top 10 hybrids produced 46.8%–73.9%and 31.2%–42.1%higher mean grain yields than the best commercial check under drought and well-watered conditions,respectively.Among the intermediate-maturing hybrids,the top 10 hybrids produced 25.2%–47.7%and 8.5%–13.5%higher grain yield than commercial checks under drought stress and well-watered conditions,respectively,suggesting improvement in the levels of drought tolerance in both early-and intermediate-maturing hybrids.GGE biplot analysis and a bi-segmented regression linear method identified specific early-maturing and intermediate-maturing hybrids that performed well under both well-watered and drought stress conditions.These hybrids could be recommended for commercial production in eastern Africa.Kakamega in Kenya was found to be the most representative and highly discriminating site among well-watered testing locations,while Kabuku in Tanzania was the least representative of test locations.For testing under drought stress conditions,Kiboko in Kenya was identified as the most representative location.This information could be useful for allocating resources and streamlining CIMMYT maize hybrid testing in eastern Africa. | Wender Santos Rezende Yoseph Beyene Stephen Mugo Eric Ndou Manje Gowda Julius Pyton Sserumaga Godfrey Asea Ismail Ngolinda McDonald Jumbo Sylvester O.Oikeh Michael Olsen Aluízio Borém Cosme Damião Cruz Boddupalli M.Prasanna | 2020 | The Crop Journal2020，8，1： | 2 |
| 4 | Efficient and simple methods for the introduction of the sulfonyl,acyl and alkyl protecting groups on the nitrogen of indole and its derivatives显示文摘 | Ottoni O Cruz R Alves R | 1998 | Tetrahedron1998，54，13： | 1 |
| 5 | Effects of salbutamol on ex- haled breath condensate biomarkers in acute lung injury:prospective analysis显示文摘 | Roca O G6mez-Oll6s S Cruz M J | 2008 | Crit Care2008，12，3： | 1 |
| 6 | The Effects of Enhanced Milieu Teaching and a Voice Output Communication Aid on the Requesting of Three Children with Autism显示文摘 | Melissa L. Olive Berenice Cruz Tonya N. Davis Jeffrey M. Chan Russell B. Lang Mark F. O’Reilly Sarah M. Dickson | 2007 | Journal of Autism and Developmental Disorders2007，，8： | 1 |
| 7 | Behavioral and neuroendocrine effects of the exposure to chronic restraint or variable stress in early adolescent rats显示文摘 | CRUZ F C MARIN M T LE ~O R M | 2012 | International Journal of Developmental Neuroscience2012，30，1： | 1 |
| 8 | Cutaneous squamous cell carcinoma:Defining the high -risk variant显示文摘 | Martorell - Calatayud A Sanmartín O Cruz J | 2013 | Actas Dermosifiliogr2013，104，5： | 1 |
| 9 | Spray pyrolysis deposition of cadmium-zinc oxide thin films 显示文摘 | Vigil O Vaillant L Cruz F | 2000 | Thin Solid Films2000，3613，62： | 1 |
| 10 | Kernel methods and their p otential use in signal processing显示文摘 | Cruz F P Bousquet O | 2004 | Signal Proees sing Magazine2004，21，： | 1 |
| 11 | A study of the poten- tial of the pig as a model for the vaginal irritancy of benzalko- nium chloride in comparison to the nonirritant microbicide PHI-443 and the spermicide vanadocene dithiocarbamate显示文摘 | D' Cruz O J Erbeck D Uckun FM | 2005 | Toxicol Pathol2005，33，4： | 1 |
| 12 | Molecular simulation study of peptide amphiphile self-assembly显示文摘 | Velichko Y S Stupp S I dela Cruz M O | 2008 | J Phys Chem B2008，112，8： | 1 |
| 13 | Responses of seven diverse rice cultivars to water deficits I · Stress development, canopy temperature, leaf rolling and growth显示文摘 | Turner N C O’Toole J C Cruz R T | 1986 | Field Crops Research1986，13，： | 1 |
| 14 | Composition of par α-rubber-seed-oil显示文摘 | Tuason A M Cruz A O | 1953 | The Philippine Journal of Science1953，82，4： | 1 |
| 15 | Spray Pyrolysis Depositi on of Cadmium Zinc Oxide Thin Films显示文摘 | VIGIL O VALUANT L CRUZ F | 2000 | Thin Solid Films2000，361，1： | 1 |
| 16 | Cutaneous squamous cell carcinoma: defining the high-risk variant显示文摘 | MARTORELL-CALATAYUD A SANMARTIN JIMENEZ O CRUZ MOJARRIETA J | 2013 | Actas Dermosi- filiogr2013，104，5： | 1 |
| 17 | Spray pyrolysis deposition of cadmium-zinc oxide thin films 显示文摘 | Vigil O Vaillant L F Cruz | 2000 | Thin Solid Films2000，36，： | 1 |
| 18 | Sea state characterisation of the test site of an offshore wave energy plant显示文摘 | Jo?o M.B.P. Cruz António J.N.A. Sarmento | 2006 | Ocean Engineering2006，，5： | 1 |
| 19 | Climate influence on ge- ochemistry parameters of waters from Santana-Perolas cave sys- tem, Brazil显示文摘 | Karmann I Cruz F W Viana O | 2007 | Chemical Geology2007，244，12： | 1 |
| 20 | The tagum study I:analysis and clinical correlates of mercury in maternal and cord blood, breast milk, meconium, and infants' hair 显示文摘 | Ramirez GB Vince Cruz MC Pagulayan O | 2000 | Pediatrics2000，106，4： | 1 |
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