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| 1 | Blood classical monocytes phenotype is not altered in primary non-small cell lung cancer显示文摘AIM: To evaluate the M1 and M2 monocyte phenotype in patients with non-small cell lung cancer(NSCLC) compared to controls. Also, to examine the expression of Th1 and Th2 cytokines in plasma of NSCLC vs controls. METHODS: Freshly prepared peripheral blood mononuclear cells samples were obtained from patients with NSCLC(lung adenocarcinoma and squamous cell lung carcinoma) and from non-cancer controls. Flow cytometry was performed to investigate M1 and M2 phenotypes in peripheral monocytes(classical monocytes CD14+, CD45+ and CD16-) using conventional surface markers. Th1 and Th2 cytokine production was alsoanalysed in the plasma using cytometric bead array technique. RESULTS: There were no significant difference in expression of M1(HLA-DR) and/or M2 markers(CD163 and CD36) markers on classical monocytes in patients with NSCLC compared to non-cancer controls. Expression of CD11 b, CD11 c, CD71 and CD44 was also shown to be similar in patients with NSCLC compared to noncancer controls. Th1 and Th2 cytokines [interleukin(IL)-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12(p70), tumor necrosis factor(TNF)-α, TNF-β, and interferon-γ] analysis revealed no significant difference between patients with NSCLC and non-cancer controls. CONCLUSION: This study shows no alteration in peripheral monocyte phenotype in circulating classical monocytes in patients with NSCLC compared to noncancer controls. No difference in Th1 and Th2 cytokine levels were noted in the plasma of these patients. | Saleh A Almatroodi Christine F Mc Donald Allison L Collins I an A Darby Dodie S Pouniotis | 2014 | World Journal of Clinical Oncology2014，5，5： | 2 |
| 2 | Intellectual Human Capital and the Birth of USA显示文摘 | ZUCKER L G DARBY M R BREWER M B | 1998 | Biotechnology Enterprises American Economic Review1998，88，1： | 1 |
| 3 | Applying sustainability indi- cators to the social enterprise business model显示文摘 | Darby L Jenkins H | 2006 | International Journal of Social Economics2006，33，56： | 1 |
| 4 | Apoptosls mediates the decrease in cellularity during the transition between granulation tissue and scar显示文摘 | Desmouliere A Redard M Darby L | 1995 | Am J Pathol1995，146，： | 1 |
| 5 | Apoptosis mediates the decrease in cellularitg during the transition between granulation tissue and scar显示文摘 | Desmouli6re A Redard M Darby l | 1995 | Am J Pathol1995，146，1： | 1 |
| 6 | Intellectual human capital and the birth of US biotechnology enterprises 显示文摘 | ZUCKER L G DARBY M R BREWER M B | 1998 | American Economic Review1998，88，1： | 1 |
| 7 | An hp-adaptive pseudospectral method for solving optimal control problems 显示文摘 | Darby C L Hager W W Rao A V | 2011 | Optimal Control Applications and Methods2011，32，4： | 1 |
| 8 | MPC: current practice and challenges 显示文摘 | Darby M L Nikolaou M | 2012 | Control Engineering Practice2012，20，4： | 1 |
| 9 | Apoptosis is increased in a model of diabetes impaired wound healing in genetically diabetes mice 显示文摘 | DARBY L A | 1997 | International Journal of Biochemical Cell Biology1997，29，： | 1 |
| 10 | Past glacial and interglacial conditions in the Arctic Ocean and marginal seas-a review显示文摘 | DARBY D A POLYAK L BAUCH H A | 2006 | Progress in Oceanography2006，71，2006： | 1 |
| 11 | Production of poly- hydroxyalkanoate during treatment of tomato cannery wastewater显示文摘 | Liu H Y Hall P V Darby J L | 2008 | Water Environment Research2008，80，4： | 1 |
| 12 | The relationship between subjective assessment instruments in chronic rhino- sinuaitia显示文摘 | Lira M Lew GS Darby L | 2007 | Rhinoiogy2007，，： | 1 |
| 13 | Ultraviolet disinfection of wasterwater: Effect of dose on subsequent photoreactivation 显示文摘 | Lindenauer K G Darby J L | 1994 | Water Research1994，28，4： | 1 |
| 14 | UV disinfection of wastewater: probabilistic approach to design 显示文摘 | Loge F J Darby J L Tchobanoglous G | 1996 | J Env Eng1996，122，12： | 1 |
| 15 | Algorithm 902 :GPOPS,a MATLAB software for solving multiple-phaseoptimal control problems using the Gauss pseudospectralmethod显示文摘 | Rao A V Benson D A Darby C L | 2010 | ACM Transactions on Mathematical Software2010，37，2： | 1 |
| 16 | Intellectual hu- man capital and the birth of US biotechnology enterprises显示文摘 | ZUCKER L G DARBY M R BREWER M B | 1998 | American Economic Review1998，88，1： | 1 |
| 17 | The incidence of aymptomatic thromboembolism in patients receiving adjuvant-based chemotherapy for early stage breast cancer显示文摘 | i] Nolan L Darby A Boleti K | 2011 | Breast2011，20，2： | 1 |
| 18 | Apopwsis mediates the decrease in cellularity during the transition between granulation tissue and scar显示文摘 | Desmouliere A Redard M Darby l | 1995 | Am J Pathol1995，146，： | 1 |
| 19 | Algorithm:GPOPS,a Matlab software for solving multiple-phase optimal control problems using the Gauss pseudospeetral method显示文摘 | RAO A V BENSON D A DARBY C L | 2010 | ACM Transactions on Mathematical Software2010，37，2： | 1 |
| 20 | Algo- rithm 902: GPOPS, a MATLAB software for solving multiple-phase optimal control problems using 显示文摘 | RAO A V BENSON D A DARBY C L | 2010 | ACM Transactions on Mathematical Software2010，37，2： | 1 |
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