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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Acute fatty liver of pregnancy associated with severe acute pancreatitis:A case report显示文摘Acute fatty liver of pregnancy is a rare disease that affects women in the third trimester of pregnancy. Although infrequent, the disease can cause maternal mortality. The diagnosis is not always clear until the pregnancy is terminated, and significant complications, such as acute pancreatitis, can occur. Pancreatic involvement typically only occurs in severe cases after the development of hepatic and renal impairment. To date, little knowledge is available regarding how the disease causes pancreatitis. Treatment involves supportive measures and pregnancy interruption. In this report, we describe a case of a previously healthy 26-year-old woman at a gestational age of 27 wk and 6 d who was admitted with severe abdominal pain and vomiting. This case illustrates the clinical and laboratory overlap between acute fatty liver of pregnancy and pancreatitis, highlighting the difficulties in differentiating each disease. Furthermore, the hypothesis for this overlapping is presented, and the therapeutic options are discussed. | Cássio Vieira de Oliveira Alecsro Moreira Julio P Baima Leticia de C Franzoni Talles B Lima Fabio da S Yamashiro Kunie Yabuki Rabelo Coelho Ligia Y Sassaki Carlos Antonio Caramori Ferno G Romeiro Giovanni F Silva | 2014 | World Journal of Hepatology2014，6，7： | 3 |
| 3 | The corpus cavernosum after treatment with dutasteride or finasteride: a histomorphometric study in a benign prostatic hyperplasia rodent model显示文摘 | Marcello H A Da Silva Waldemar S Costa Francisco J B Sampaio Diogo B De Souza | 2018 | Asian Journal of Andrology2018，20，5： | 2 |
| 4 | Quantification of catechin and poranthocyanidins in several portuguese grapevine varieties and red wines 显示文摘 | Sun B S Ricardo da Silva J Mv Spranger M | 2001 | Ciencia E Tecnica Vitivinico- la2001，16，1： | 1 |
| 5 | Parametric Study of Adhesive Joints with Composites 显示文摘 | NETO J A B P CAMPILHO R D S G DA SILVA L F M | 2012 | International Journal of Adhesion and Adhesives2012，，： | 1 |
| 6 | Immune system and immune responses in fish and their role in com- parative immunity study: a model for higher organisms 显示文摘 | RAUTA P R NAYAK B DA S S | 2012 | Immunology Letters2012，148，1： | 1 |
| 7 | Recovery of rhamnolipids produced by pseudomonas aeruginosa using acidic precipitation, extraction, and ad- sorption on activated carbon 显示文摘 | CARMENDSM D O A DA S B M DE A PC E | 2013 | Separation Science and Technology2013，48，18： | 1 |
| 8 | Efficacy assessment oftwo antibiotic prophylaxis regimens in oral and maxillofacialtrauma surgery: preliminary results显示文摘 | Campos G B Lucena E E da Silva J S | 2015 | Int J Clin Exp Med2015，8，2： | 1 |
| 9 | Cusp gun TE21 second-harmonic Ka-band gyro-TWT amplifier显示文摘 | HARRIET S B MCDERMOTT D B GALLAGHER DA | 2002 | IEEE Trans Plasma Science2002，30，3： | 1 |
| 10 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 11 | Cooperative Dual-hop Relaying Systems with Beamforming over Nakagami - m Fading Channels 显示文摘 | Costa D B da Aissa S | 2009 | IEEE Transactions on Wireless Communications2009，8，8： | 1 |
| 12 | A new model for heterotopic heart transplantation in rodents: graft atrial septectomy显示文摘 | Steinbrachel DA Nielsen B Salomon S | 1994 | Transplant proc1994，26，： | 1 |
| 13 | High-contrast imaging (FICE) improves visualization of gastrointestinal vascular ectasias显示文摘 | Ringold DA Sikka S Banerjee B | 2008 | Endoscopy2008，402，： | 1 |
| 14 | Monte Carlomodeling of surface excitation in reflection electron energy loss spectroscopy spectrum for rough surfaces显示文摘 | Da B Mao S F Zhang G H | 2012 | Journal of Applied Physics2012，112，03： | 1 |
| 15 | Elevated oxidative stress in models of normal brain aging and Alzheimer's disease显示文摘 | Butterfield DA Howard B Yatin S | 1999 | Life Sci1999，65，18： | 1 |
| 16 | Nogo-A,-B,and-C are found on the cell surface and interact together in many different cell types显示文摘 | Dodd DA Niederoest B Bloechlinger S | 2005 | J Biol Chem2005，280，12： | 1 |
| 17 | Assessment of aroma impact compounds in a cashew apple-based alcoholic beverage by GC-MS and GC-olfactometry显示文摘 | GARRUTI D S FRANCO M R B da SILVA M A | 2006 | LWT-Food Science and Technology2006，39，4： | 1 |
| 18 | Wound management with vacuum- assisted closure:experience in 51 pediatric patients显示文摘 | Caniano DA Ruth B Teich S | 2005 | J Pediatr Surg2005，40，1： | 1 |
| 19 | The application ofbiotechnology to orchids显示文摘 | Hossain M M Kant R Van P T Winarto B Zeng S J Teixeira da Silva J A | | 0，，02： | 1 |
| 20 | A microporous membrane interface for the monitoring of dissolved gaseous and volatile compounds by on- line mass spectrometry显示文摘 | Ferreira B S van Keulen F da Fonseca M M R | 2002 | J Mernbr Sci2002，208，12： | 1 |
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