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| 1 | 草莓组培苗的光合能力与强制通气对其生长的影响显示文摘组培草莓(Fragaria ananassa Duch.)小苗具有正常光合能力。但其光合作用与生长受培养容器内气体条件的影响。在培养阶段进行强制通气可促进小苗的生长。与通常条件下培养的小苗相比,在移植前,通气使地上部分与根的鲜重分别增加 44%与 100%。在温室内驯化4星期后,通气条件下培养的小苗地上部与地下部分的鲜重仍分别比不通气条件下培养的小苗多80%与109%。 | 月德 Yves Desjardins André Gosselin | 1993 | 园艺学报1993，20，2： | 7 |
| 2 | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study显示文摘High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures.Here,we demonstrate that an all-optical ultrasound transducer,through which light guided by optical fibers is used to generate and receive ultrasound,is suitable for real-time invasive medical imaging in vivo.Broad-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed laser.The interrogation of a high-finesse Fabry–Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound reception.This transducer was integrated within a custom inner transseptal needle(diameter 1.08 mm;length 78 cm)that included a metallic septum to acoustically isolate the two optical fibers.The use of this needle within the beating heart of a pig provided unprecedented realtime views(50 Hz scan rate)of cardiac tissue(depth:2.5 cm;axial resolution:64μm)and revealed the critical anatomical structures required to safely perform a transseptal crossing:the right and left atrial walls,the right atrial appendage,and the limbus fossae ovalis.This new paradigm will allow ultrasound imaging to be integrated into a broad range of minimally invasive devices in different clinical contexts. | Malcolm C Finlay Charles A Mosse Richard J Colchester Sacha Noimark Edward Z Zhang Sebastien Ourselin Paul C Beard Richard J Schilling Ivan P Parkin Ioannis Papakonstantinou Adrien E Desjardins | 2017 | Light(Science & Applications)2017，6，1： | 6 |
| 3 | A randomized double-blind controlled trial: Impact of probiotics on diarrhea in patients treated with pelvic radiation显示文摘 | Mimi Demers Anne Dagnault Josée Desjardins | 2013 | Clinical Nutrition2013，，： | 3 |
| 4 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 5 | Maternal Contributions: Supporting Language Development in Young Children with Cochlear Implants显示文摘 | Jean L. DesJardin Laurie S. Eisenberg | 2007 | Ear and Hearing2007，，4： | 2 |
| 6 | A comparison of the clinical and experimental characteristics of four acute surgical pain models: Dental extraction, bunionectomy, joint replacement, and soft tissue surgery显示文摘 | Neil K. Singla Paul J. Desjardins Phoebe D. Chang | 2014 | Pain2014，，3： | 2 |
| 7 | 血管生成素样蛋白2水平与肾移植术后主动脉僵硬度和死亡率呈正相关显示文摘血管生成素样蛋白2(angiopoietin-like-2,ANGPTL2)是一种分泌性糖蛋白,可诱发血管内皮功能障碍、动脉粥样硬化和心血管病。循环ANGPTL2在慢性肾脏病(chronic kidney disease,CKD)患者中增加,加重患心血管病的风险。 | Desjardins MP Thorin-Trescases N Sidibé A Fortier C DeSerres SA Larivière R Thorin E Agharazii M 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 8 | Comparison of the ABI7700 system (Taq Man) and competitive PCR for quantification of IS6110 DNA in sputum during treatment of tuberculosis 显示文摘 | Desjardin LE Chen Y Perkins MD | 1998 | J Clin Microbil1998，36，7： | 1 |
| 9 | Photosynthesis in vitro-On the factors regulating CO2as- sinilation in micropropagation systems 显示文摘 | Desjardins Y | 1995 | Acta Hort1995，359，： | 1 |
| 10 | Growth of bifidobacteria and their enzyme profiles显示文摘 | DESJARDINS M L ROY D | 1990 | Dairy Sci1990，73，： | 1 |
| 11 | Analgesic efficacy of intranasal bulorphanol in the treatment of pain after dental impaction surgery显示文摘 | Desjardins PJ | 2000 | Journal Maxillofae Surg2000，58，102： | 1 |
| 12 | Existence of weak solutions for the motion of rigid bodies in a viscous fluid 显示文摘 | DESJARDINS B ESTEBAN M J | 1999 | Archive Rat Mech Anal1999，146，： | 1 |
| 13 | Carbon dioxide budget of Maize 显示文摘 | Desjardins R L | 1985 | Agric For Meteorol1985，36，1： | 1 |
| 14 | ECG-gated cardiac CT 显示文摘 | Desjardins B Kazerooni EA | 2004 | AJR Am J Roentgenol2004，182，4： | 1 |
| 15 | Comparison of the ABI7700 system (TaqMan) and competitive PCR for quantifivation of IS6110 DNA in sputum during treatment of tuberculosis 显示文摘 | Desjardin LE Chen Y Perkins MD | 1998 | J Clin Microbil1998，36，7： | 1 |
| 16 | Unstable intertrochanteric fracture of femur: a prospective randomized study comparing anatomical reduction and medial displace- ment osteotomy 显示文摘 | DESJARDINS AL ROY A PAIEMENT G | 1993 | J Bone Joint Surg (Br)1993，75，3： | 1 |
| 17 | A pressure overload model of congestive heart failure in rats显示文摘 | Desjardins S Mueller RW Cauchy MJ | 1988 | Ca- rdiovasc Res1988，22，10： | 1 |
| 18 | Bevacizumab plus irinotecan in recurrent glioblastoma muhiforme 显示文摘 | Vredenburah JJ Desjardins A Hemdon JE | 2007 | J Clin Oncol2007，25，30： | 1 |
| 19 | Clinical utility of blood cultures drawn from indwelling central venous catheters in hospitalized patients with cancer显示文摘 | DesJardin JA Falagas ME Ruthazer R | 1999 | Ann Intern Med1999，131，9： | 1 |
| 20 | Adjustment of footprint correction for airborne flux mapping over the FIFE sits 显示文摘 | SCHUEPP P H MACPHERSON J I DESJARDINS R L | 1992 | J Geophys Res1992，97，18： | 1 |
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