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| 1 | Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease显示文摘AIM: To evaluate the results of the treatment of simple liver cysts (solitary and multiple) and polycystic liver disease (PLD) using percutaneous sclerotherapy and/or surgical procedures in a single tertiary referral centre. METHODS: Retrospective analysis of 54 patients referred for evaluation and possible treatment of simple liver cysts (solitary and multiple) and PLD, from January 1997 to July 2006. RESULTS: Simple liver cysts were treated in 41 pts (76/) with a mean size of 12.6 cm. The most common reason for referral was abdominal pain or discomfort (85/). Percutaneous sclerotherapy was performed as initial treatment in 30 pts, showing cyst recurrence in 6 pts (20/). Surgical treatment was initially performed in 11 pts with cyst recurrence in 3 pts (27/). PLD was treated in 13 pts (24/) with a mean size of the dominant cyst of 13 cm. Percutaneous sclerotherapy for PLD was performed in 9 pts with recurrence in 7 pts (77.8/). Surgical treatment for PLD was undertaken in 4 pts (30.8/) with recurrence in all. Eventually, 2 pts with PLD in the presence of polycystic kidney disease underwent liver-and kidney transplantation because of deterioration of liver and kidney function. CONCLUSION: The majority of patients with simple liver cysts and PLD are referred for progressive abdominal pain. As initial treatment, percutaneous sclerotherapy is appropriate. Surgical deroofing is indicated in caseof cyst recurrence after percutaneous sclerotherapy. However, the results of percutaneous sclerotherapy and surgical treatment for PLD are disappointing. Partial liver resection is indicated when there is suspicion of a pre-malignant lesion. | Deha Erdogan Otto M van Delden Erik AJ Rauws Olivier RC Busch Johan S Lameris Dirk J Gouma Thomas M van Gulik | 2007 | World Journal of Gastroenterology2007，13，22： | 15 |
| 2 | Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study显示文摘 | Hedy L Kindler Tatsuya Ioka Dirk J Richel Jaafar Bennouna Richard Létourneau Takuji Okusaka Akihiro Funakoshi Junji Furuse Young Suk Park Shinichi Ohkawa Gregory M Springett Harpreet S Wasan Peter C Trask Paul Bycott Alejandro D Ricart Sinil Kim Eric Van | 2011 | Lancet Oncology2011，，3： | 4 |
| 3 | Systematic analysis of the safety and benefits of transvaginal hybrid-NOTES cholecystectomy显示文摘AIM: To evaluate transvaginal hybrid-NOTES cholecystectomy(TVC) during its clinical establishment and compare it with the traditional laparoscopic technique(LC).METHODS: The specific problems and benefits of TVC were reviewed using a registry analysis,a comparative cohort study and a randomized clinical trial. At first,feasibility,safety and specific complications of the TVC were analyzed based on the first 488 data sets of the German NOTES Registry(GNR). Hereafter,we compared the early postoperative results of our first 50 TVC-patients with those of 50 female LCpatients matched by age,BMI and ASA classification. The same cohort was contacted an average of two years later to evaluate long-term results concerning pain and satisfaction with the aesthetic results and the overall postoperative results as well as sexual intercourse by means of two domains of the German version of the Female Sexual Function Index(FSFI-d). Consequently,we performed a randomized clinical trial comparing 20 TVC-patients with 20 needlescopic/3-trocar cholecystectomies(NC) also concerning the early postoperative results as well as pain,satisfaction and quality of life by means of the Eypasch Gastrointestinal Quality of Life Index(GIQLI) in the later course. Finally,we discussed the results in accordance with other published studies.RESULTS: The complication(3.5%) and conversion rates(4.1%) for TVC were low in the GNR and comparable to those of the LC. Access related intraoperative complications included injuries to the bladder(n = 4; 0.8%) and bowel(n = 3; 0.6%). The study cohort revealed less postoperative pain after TVC comparing to the LC-patients on the day of surgery(NRS,1.5/10 vs 3.1/10,P = 0.003),in the morning(NRS,1.9/10 vs 2.8/10,P = 0.047) and in the evening(NRS,1.1/10 vs 1.8/10,P = 0.025) of postoperative day(POD) one. The randomized clinical trial consistently found less cumulative pain until POD 2(NRS,8/40 vs 14/40,P = 0.043),as well as until POD 10(NRS,22/190 vs 41/190,P = 0.010). Furthermore,the TVC-patients had a better quality of life on POD 10 than did the LC-patients(GIQLI,124/144 vs 107/144,P = 0.028). The complication rates were comparable and no specific problems were detected in the long-term follow-up for sexual intercourse for either group. The TVC-patients were more satisfied with the aesthetic result in the long-term course in the matched cohort analysis(1.00 vs 1.88,P < 0.001) as well as in the randomized clinical trial(1.00 vs 1.70,P < 0.001) when compared with the LC-patients.CONCLUSION: TVC is a feasible procedure with a high safety profile and has advantages in regard to postoperative pain and aesthetic results when compared with LC or NC. | Dirk R Bulian Jurgen Knuth Kai S Lehmann Axel Sauerwald Markus M Heiss | 2015 | World Journal of Gastroenterology2015，21，38： | 3 |
| 4 | comparison of different transformation for Aspergillus giganteus显示文摘 | Vera M Dirk M Till S | 2003 | Curr Genet2003，43，： | 1 |
| 5 | Assess-ment of C budget for grasslands and drylands of the world显示文摘 | Ojima D S Dirk B 0 M Gleovn E P | 1993 | Water Air Soil Pollut1993，70，： | 1 |
| 6 | The role of apopto- sis in the normal aging brain, skeletal muscle, and heart显示文摘 | POLLACK M PHANEUF S DIRKS A | 2002 | Ann N Y Acad Sci2002，959，： | 1 |
| 7 | A six- month randomized clinical trial comparing the intraocular pressure-lowering efficacy of bimatoprost and latanoprost in patients with ocular hypertension or glaucoma 显示文摘 | NOECKER R S DIRKS M S CHOPLIN N T | 2003 | Am J Ophthalmol2003，135，1： | 1 |
| 8 | Bimatoprost versus latanoprost in lowering intraocular pressure in glaucoma and ocular hypertension: results from parallel- group comparison trials 显示文摘 | SIMMONS S T DIRKS M S NOECKER R J | 2004 | Adv Ther2004，21，4： | 1 |
| 9 | Long-term effects of mineral versus organic fertilizers on activity and structure of the methanotrophic community in agricultural soils 显示文摘 | Dave S Eva M T Dirk R | 2003 | Environmental Microbiology2003，5，10： | 1 |
| 10 | Correlation between microbiological chemical parameten of some populations in petroleum-contaminated groundwater discharged from underground crude oil storage cavities显示文摘 | Bart omiej R Dirk S M | | 0，，11： | 1 |
| 11 | Assessment of C budget for grasslands and dry lands of the world 显示文摘 | OJIMA D S DIRKS B O M GLEOVEN E P | 1993 | Water Soil Poll1993，70，： | 1 |
| 12 | Common questions about prone positioning for ARDS显示文摘 | Dirkes S M Dickinson S P | 1998 | Am J Nurs1998，98，6： | 1 |
| 13 | Assessment of C budget for grasslands and drylands of the world显示文摘 | Dirk B O M Gleovn E P Owensby C E | 1993 | Water Air Soil Pollut1993，70，： | 1 |
| 14 | An algorithm for continuous real-time QT interval monitoring显示文摘 | ERICD H SOPHTA H Z JAMES M L DIRK Q F RICHARD E G JOHN J W SCOTT S K FRANCIS P M | 2006 | Journal of Electrocardiology2006，39，： | 1 |
| 15 | Assessment of C budget for grasslands and dry lands of the world显示文摘 | Ojima D S Dirks B O M Gleovn E P | 1993 | Water Air and Soil Pollution1993，70，： | 1 |
| 16 | Microvascular ischemia reperfusion injttry in striated muscle: significance of 'reflow paradox' 显示文摘 | Menger M D Stefan P Dirk S | 1992 | Am J Physiol1992，263，： | 1 |
| 17 | Molecular evolution of the small subunit ribosomal DNA in Woodlice (Crustacea,Isopoda,Oniscidea) and implications for oniscidean phylogeny显示文摘 | Dirk M Martin S | 2001 | Mol Phyl Evol2001，18，1： | 1 |
| 18 | Mechanism of cell entry and transformation by enzootic nasal tumor virus 显示文摘 | Dirks C Duh F M Rai S K | 2002 | J Virol2002，76，5： | 1 |
| 19 | The role of apoptosis in the normal aging brain,skeletal muscle,and heart显示文摘 | Pollack M Phaneuf S Dirks A | 2002 | Ann N Y Acad Sci2002，959，2： | 1 |
| 20 | The role of apoptosis in the normal aging brain,skeletal muscle,and heart显示文摘 | POLLACK M PHANEUF S DIRKS A | 2002 | Ann N Y Acad Sci2002，959，： | 1 |
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